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Abstract

Influenza virus imprinting is now understood to significantly influence the immune responses and clinical outcome of influenza virus infections that occur later in life. Due to the yearly cycling of influenza viruses, humans are imprinted with the circulating virus of their birth year and...

Author(s)
Francis, M. E.; McNeil, M.; Dawe, N. J.; Foley, M. K.; King, M. L.; Ross, T. M.; Kelvin, A. A.
Publisher
MDPI AG, Basel, Switzerland
Citation
Vaccines, 2019, 7, 4,
Abstract

Background Vaccination is the most effective approach to prevent infection with highly pathogenic avian influenza (HPAI). Adjuvants are often used to induce effective immune responses and overcome the immunological weakness of recombinant HPAI antigens. Given the logistical challenges of...

Author(s)
Wang SuHe; Chen, J.; Smith, D.; Cao ZhengYi; Acosta, H.; Fan YongYi; Ciotti, S.; Fattom, A.; Baker, J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Vaccine, 2020, 38, 19, pp 3537-3544
Abstract

Background: Taiwan had been considered rabies free since 1961, until a newly established wildlife disease surveillance program identified rabies virus transmission within the Formosan ferret-badger (Melogale moschata subaurantiaca) in 2013. Ferret-badgers occur throughout southern China and...

Author(s)
Wallace, R. M.; Lai YuChing; Doty, J. B.; Chen ChenChih; Vora, N. M.; Blanton, J. D.; Chang, S. S.; Cleaton, J. M.; Pei, K. J. C.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2018, 13, 1, pp e0189998
Abstract

Current influenza vaccines do not provide effective protection against heterologous influenza viruses. The ability of the novel M2SR influenza vaccine to protect against drifted influenza viruses was evaluated in naïve ferrets and in ferrets with pre-existing immunity to influenza. In naïve ...

Author(s)
Hatta, Y.; Boltz, D.; Sarawar, S.; Kawaoka, Y.; Neumann, G.; Bilsel, P.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Vaccine, 2018, 36, 33, pp 5097-5103
Abstract

Most preclinical animal studies test influenza vaccines in immunologically naive animal models, even though the results of vaccination may not accurately reflect the effectiveness of vaccine candidates in humans that have preexisting immunity to influenza. In this study, novel, broadly reactive...

Author(s)
Carter, D. M.; Darby, C. A.; Johnson, S. K.; Carlock, M. A.; Kirchenbaum, G. A.; Allen, J. D.; Vogel, T. U.; Delagrave, S.; DiNapoli, J.; Kleanthous, H.; Ross, T. M.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Journal of Virology, 2017, 91, 24, pp e01283-17
Abstract

The domestic ferret (Mustela putorius furo) is a commonly used animal model for the study of influenza virus infection and vaccination. Recently, our group has developed murine mAbs with specificity for the κ (Igκ) and λ (Igλ) L chains of ferret Ig. These mAbs were used to quantify the abundance of ...

Author(s)
Kirchenbaum, G. A.; Allen, J. D.; Layman, T. S.; Sautto, G. A.; Ross, T. M.
Publisher
American Association of Immunologists, Bethesda, USA
Citation
Journal of Immunology, 2017, 199, 11, pp 3798-3807
Abstract

Seasonal influenza viruses cause significant morbidity and mortality in the global population every year. Although seasonal vaccination limits disease, mismatches between the circulating strain and the vaccine strain can severely impair vaccine effectiveness. Because of this, there is an urgent...

Author(s)
McMahon, M.; Arunkumar, G. A.; Liu WenChun; Stadlbauer, D.; Albrecht, R. A.; Pavot, V.; Aramouni, M.; Lambe, T.; Gilbert, S. C.; Krammer, F.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Immunology, 2019, 10, August, pp 2005
Abstract

Companion ferrets need to be vaccinated against 2 viral diseases that cause neurologic illness: canine distemper and rabies. Although not common in ferrets, both viruses are fatal in ferrets and rabies virus is also fatal in humans. In this article, we provide a basic review of the 2 diseases,...

Author(s)
Wade, L. L.
Publisher
Saunders, An Imprint of Elsevier, Philadelphia, USA
Citation
Veterinary Clinics of North America: Exotic Animal Practice, 2018, 21, 1, pp 105-114
Abstract

To evaluate the efficacy of a non-adjuvant A/H1N1/2009 influenza A vaccine (GC1115), we demonstrated the immunogenicity and protective efficacy of GC1115 in mouse and ferret models. The immunogenicity of GC1115 was confirmed after intramuscular administration of 1.875, 3.75, 7.5, and 15 µg...

Author(s)
Han HaeJung; Song MinSuk; Park SuJin; Byun HanYeul; Robles, N. J. C.; Ha SukHoon; Choi YoungKi
Publisher
The Microbiological Society of Korea (MSK), Seoul, Korea Republic
Citation
The Journal of Microbiology, 2019, 57, 2, pp 163-169
Abstract

Since 2013, rabies cases have been reported among Formosan ferret badgers in Taiwan, and they have been shown to be the major reservoirs for Taiwanese enzootics. To control and eradicate rabies, the authorities plan to implement a vaccination programme. Before distributing live vaccines in the...

Author(s)
Hsu AiPing; Tseng ChunHsien; Barrat, J.; Lee ShuHwae; Shih YuHua; Wasniewski, M.; Mähl, P.; Chang ChiaChia; Lin ChunTa; Chen ReShang; Tu WenJane; Cliquet, F.; Tsai HsiangJung
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2017, 12, 10, pp e0184831

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