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Abstract

Nipah virus (NiV) is a pathogenic paramyxovirus and zoononis with very high human fatality rates. Previous protein over-expression studies have shown that various mutations to the common N-terminal STAT1-binding motif of the NiV P, V, and W proteins affected the STAT1-binding ability of these...

Author(s)
Satterfield, B. A.; Borisevich, V.; Foster, S. L.; Rodriguez, S. E.; Cross, R. W.; Fenton, K. A.; Agans, K. N.; Basler, C. F.; Geisbert, T. W.; Mire, C. E.
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2019, 9, 1, pp 16710
Abstract

Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes lethal encephalitis in humans. We previously reported that the V protein, one of the three accessory proteins encoded by the P gene, is one of the key determinants of the pathogenesis of NiV in a hamster infection model. Satterfield ...

Author(s)
Uchida, S.; Horie, R.; Sato, H.; Kai, C.; Yoneda, M.
Publisher
Nature Publishing Group, London, UK
Citation
Scientific Reports, 2018, 8, 1, pp 7682
Abstract

Oseltamivir is a common therapy against influenza A virus (IAV) infections. The acquisition of oseltamivir resistance (OR) mutations, such as H275Y, hampers viral fitness. However, OR H1N1 viruses have demonstrated the ability to spread throughout different populations. The objective of this work...

Author(s)
Vidaña, B.; Martínez-Orellana, P.; Martorell, J. M.; Baratelli, M.; Martínez, J.; Migura-Garcia, L.; Córdoba, L.; Pérez, M.; Casas, I.; Pozo, F.; Fraile, L.; Majó, N.; Montoya, M.
Publisher
MDPI AG, Basel, Switzerland
Citation
Viruses, 2020, 12, 8,
Abstract

Current influenza vaccines only confer protection against homologous viruses. We synthesized pulmonary surfactant (PS)-biomimetic liposomes encapsulating 2',3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), an agonist of the interferon gene inducer STING (stimulator of interferon...

Author(s)
Wang Ji; Li PeiYu; Yu Yang; Fu YuHong; Jiang HongYe; Lu Min; Sun ZhiPing; Jiang ShiBo; Lu Lu; Wu, M. X.
Publisher
American Association for the Advancement of Science, Washington, USA
Citation
Science (Washington), 2020, 367, 6480,
Abstract

Henipavirus infection causes severe respiratory and neurological disease in humans that can be fatal. To characterize the pathogenic mechanisms of henipavirus infection in vivo, we performed experimental infections in ferrets followed by genome-wide gene expression analysis of lung and brain...

Author(s)
Leon, A. J.; Borisevich, V.; Boroumand, N.; Seymour, R.; Nusbaum, R.; Escaffre, O.; Xu LuoLing; Kelvin, D. J.; Rockx, B.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS Neglected Tropical Diseases, 2018, 12, 3, pp e0006343
Abstract

Seasonal influenza viruses cause significant morbidity and mortality in the global population every year. Although seasonal vaccination limits disease, mismatches between the circulating strain and the vaccine strain can severely impair vaccine effectiveness. Because of this, there is an urgent...

Author(s)
McMahon, M.; Arunkumar, G. A.; Liu WenChun; Stadlbauer, D.; Albrecht, R. A.; Pavot, V.; Aramouni, M.; Lambe, T.; Gilbert, S. C.; Krammer, F.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Immunology, 2019, 10, August, pp 2005
Abstract

The burden of infection with seasonal influenza viruses is significant. Each year is typically characterized by the dominance of one (sub)type or lineage of influenza A or B virus, respectively. The incidence of disease varies annually, and while this may be attributed to a particular virus strain...

Author(s)
Carolan, L. A.; Rockman, S.; Borg, K.; Guarnaccia, T.; Reading, P.; Mosse, J.; Kelso, A.; Barr, I.; Laurie, K. L.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Journal of Virology, 2016, 90, 6, pp 2838-2848
Abstract

Pigs play an important role in the interspecies transmission of influenza A viruses (IAV). The porcine airway epithelium contains binding sites for both swine/human IAV (α2,6-linked sialic acids) and avian IAV (α2,3-linked sialic acids) and therefore is suited for adaptation of viruses from other...

Author(s)
Shin DaiLun; Yang Wei; Peng JuYi; Sawatsky, B.; Messling, V. von; Herrler, G.; Wu NaiHuei
Publisher
MDPI AG, Basel, Switzerland
Citation
Viruses, 2020, 12, 6,
Abstract

The ferret is an excellent model for many human infectious diseases including influenza, SARS-CoV, henipavirus and pneumococcal infections. The ferret is also used to study cystic fibrosis and various cancers, as well as reproductive biology and physiology. However, the range of reagents available...

Author(s)
Carolan, L. A.; Butler, J.; Rockman, S.; Guarnaccia, T.; Hurt, A. C.; Reading, P.; Kelso, A.; Barr, I.; Laurie, K. L.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Journal of Virological Methods, 2014, 205, pp 38-52
Abstract

Ferrets (Mustela putorius furo) develop symptoms upon influenza infection that resemble those of humans, including sneezing, body temperature variation and weight loss. Highly pathogenic strains of influenza A, such as H5N1, have the capacity to cause severe illness or death in ferrets. The use of ...

Author(s)
Ochi, A.; Danesh, A.; Seneviratne, C.; Banner, D.; Devries, M. E.; Rowe, T.; Xu LuoLing; Ran LongSi; Czub, M.; Bosinger, S. E.; Cameron, M. J.; Cameron, C. M.; Kelvin, D. J.
Publisher
Elsevier, New York, USA
Citation
Developmental and Comparative Immunology, 2008, 32, 8, pp 890-897

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