Recombinant canine distemper virus as a possible vector for the delivery of SIV antigens - establishment and evaluation of biosafety and immunogenicity of rCDV and rCDV-SIVgag in the ferret model HIV/AIDS has been termed one of the most devastating diseases of mankind. Due to the unique...

Upon infection, morbilliviruses such as measles virus, rinderpest virus, and canine distemper virus (CDV) initially target immune cells via the signaling lymphocyte activation molecule (SLAM) before spreading to respiratory epithelia through the adherens junction protein nectin-4. However, the...

Red pandas (Ailurus fulgens) are susceptible to canine distemper, with a number of reported vaccine-induced canine distemper cases. Canarypox-vectored recombinant canine distemper vaccines (PureVax Ferret Distemper [PFD] and Recombitek CDV [rCDV]) provide protection without inoculating a live ...

Companion ferrets need to be vaccinated against 2 viral diseases that cause neurologic illness: canine distemper and rabies. Although not common in ferrets, both viruses are fatal in ferrets and rabies virus is also fatal in humans. In this article, we provide a basic review of the 2 diseases,...

This chapter discusses etiology, transmission and epidemiology, clinical signs, pathology, diagnosis, treatment and prevention of viral diseases of ferrets. The viruses discussed in the chapter are: canine distemper virus (CDV), ferret coronaviruses, Aleutian disease virus (ADV), influenza viruses, ...

Objective: To determine the status and distribution of distemper in Australian dogs and ferrets. Design: Retrospective case series. Methods: Cases were identified via a national voluntary disease reporting system, veterinarian groups and a national laboratory database. The geographic distribution,...

Two methods for delivering a canarypox-vectored canine distemper vaccine to tigers (Panthera tigris) and domestic cats (Felis catus) were investigated. Eight tigers were divided randomly into two vaccination groups: subcutaneous injection or topical tonsillar application. Each tiger received 2 ml...

One-hundred-fifty pet ferrets, 16 weeks to 8 years of age, were evaluated for the presence of serum-neutralizing (SN) antibody titers against canine distemper virus (CDV) vaccine. All ferrets received an initial vaccine at the source of origin some time before 9 weeks of age, and one or more...

Canine distemper virus (CDV) elicits a severe contagious disease in a broad range of hosts. CDV mortality rates are 50% in domestic dogs and 100% in ferrets. Its primary infection sites are respiratory and intestinal mucosa. This study aimed to develop an effective mucosal CDV vaccine using a...

This study evaluated the safety of and humoral response to the Merial Recombitek^® recombinant canine distemper virus (rCDV) vaccine in maned wolves (n = 9, age 2-9 yr). All maned wolves had prior history of annual vaccination with the Merial Purevax^® ferret rCDV vaccine. Serum neutralization (SN)...