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Abstract

Erythrocyte pyruvate kinase (PK) deficiency is an inherited glycolytic erythroenzymopathy caused by mutations of the PKLR gene. A causative mutation of the feline PKLR gene was originally identified in Abyssinian and Somali cats in the U.S.A. In the present study, a TaqMan probe-based real-time PCR ...

Author(s)
Kushida, K.; Giger, U.; Tsutsui, T.; Inaba, M.; Konno, Y.; Hayashi, K.; Noguchi, K.; Yabuki, A.; Mizukami, K.; Kohyama, M.; Endo, Y.; Yamato, O.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2015, 77, 6, pp 743-746
Abstract

This case report describes the clinical findings and course of the disease in an Abyssinian cat suffering from erythrocytic pyruvate kinase deficiency (PKD). Feline PKD is a hereditary disease, following an autosomal recessive mode of inheritance. Abyssinian and Somali breeds are predominantly...

Author(s)
König, T.
Publisher
Schattauer GmbH, Stuttgart, Germany
Citation
Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, 2008, 36, 4, pp 270, 285-289
Abstract

The objective of this study was to examine clinical signs, laboratory parameters, and course of disease in Abyssinian and Somali cats with pyruvate kinase (PK) deficiency. The clinical course of 25 PK-deficient cats was followed over a time period of 0.8-11.3 years (median 4.3). Eleven cats (age...

Author(s)
Kohn, B.; Fumi, C.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Journal of Feline Medicine and Surgery, 2008, 10, 2, pp 145-153
Abstract

Background: Erythrocyte Pyruvate Kinase Deficiency (PK deficiency) is an inherited hemolytic anemia that has been documented in the Abyssinian and Somali breeds as well as random bred domestic shorthair cats. The disease results from mutations in PKLR, the gene encoding the regulatory glycolytic...

Author(s)
Grahn, R. A.; Grahn, J. C.; Penedo, M. C. T.; Helps, C. R.; Lyons, L. A.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2012, 8, 207, pp (30 October 2012)
Abstract

Objective: To determine the frequency of the mutant pyruvate kinase (PK) allele, haematological parameters and AB blood types of Abyssinian and Somali cats in Australia. Design: Complete blood cell and reticulocyte counts, DNA PK mutation testing and blood typing were performed in all cats....

Author(s)
Barrs, V. R.; Giger, U.; Wilson, B.; Chan, C. T. T.; Lingard, A. E.; Tran, L.; Seng, A.; Canfield, P. J.; Beatty, J. A.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Australian Veterinary Journal, 2009, 87, 1, pp 39-44
Abstract

Following the description of erythrocytic pyruvate kinase (PK) deficiency in Somali and Abyssinian cats in the United States we describe here the first case of PK deficiency in a male Somali cat in Germany. This cat which had been used for breeding showed intermittent lethargy, anorexia, anemia and ...

Author(s)
Kohn, B.; Fumi, C.; Seng, A.; Giger, U.
Publisher
Verlag M. & H. Schaper, Alfeld (Leine), Germany
Citation
Kleintierpraxis, 2005, 50, 5, pp 305-312
Abstract

A 2-year-old female neutered Somali cat was presented with vomiting and acute onset jaundice 1 year after diagnosis of pyruvate kinase (PK) deficiency. Diagnostic investigations revealed a moderate regenerative haemolytic anaemia, severe hyperbilirubinaemia and elevated liver enzymes....

Author(s)
Harvey, A. M.; Holt, P. E.; Barr, F. J.; Rizzo, F.; Tasker, S.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Journal of Feline Medicine and Surgery, 2007, 9, 5, pp 424-431
Abstract

This article describes the aetiology, pathogenesis, clinical signs, diagnosis and treatment of hereditary blood diseases in cats and dogs.

Author(s)
Giger, U.
Publisher
Royal Canin Ltd (UK and Ireland), Castle Cary, UK
Citation
Veterinary Focus, 2018, 28, 2, pp 32-38
Abstract

Wumeng semi-fine wool sheep are affected by a disease, characterized by emaciation, stiffness and trembling of the limbs, weakness and inability to stand, and sudden death. The objective of the study was to determine possible relationships between the disease and mineral deficiencies. Samples of...

Author(s)
Huo Bin; Wu Ting; Song ChunJie; Shen XiaoYun
Publisher
Springer US, Philadelphia, USA
Citation
Biological Trace Element Research, 2020, 194, 1, pp 152-158
Abstract

Wumeng semi-fine wool sheep are affected by a disease, characterized by emaciation, stiffness and trembling of the limbs, weakness and inability to stand, and sudden death. The objective of the study was to determine possible relationships between the disease and mineral deficiencies. Samples of...

Author(s)
Huo Bin; Wu Ting; Song ChunJie; Shen XiaoYun
Publisher
Springer US, Philadelphia, USA
Citation
Biological Trace Element Research, 2020, 194, 1, pp 152-158

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