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Abstract

Squamous cell carcinoma is the most common malignant oral tumor in cats. The late presentation is one of the factors contributing to the detrimental prognosis of this disease. The immunohistochemical expression of the p53 tumor suppressor protein has been reported in 24% to 65% of feline oral ...

Author(s)
Renzi, A.; Bonis, P. de; Morandi, L.; Lenzi, J.; Tinto, D.; Rigillo, A.; Bettini, G.; Bellei, E.; Sabattini, S.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 4, pp e0215621
Abstract

Squamous cell carcinoma is the most common oral cancer in the cat and presents as a locally aggressive lesion for which an effective therapeutic protocol remains elusive. Feline oral squamous cell carcinoma (OSCC) shares many clinical characteristics with human head and neck squamous cell carcinoma ...

Author(s)
Sparger, E. E.; Murphy, B. G.; Kamal, F. M.; Arzi, B.; Naydan, D.; Skouritakis, C. T.; Cox, D. P.; Skorupski, K.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2018, 202, pp 52-62
Abstract

Oral squamous cell carcinoma is an aggressive tumor in cats; however, molecular-targeted therapies against this tumor, including antibody therapy, have not been developed. Sensitive and specific monoclonal antibodies (mAbs) against highly expressed membrane proteins are needed to develop antibody...

Author(s)
Itai, S.; Yamada, S.; Kaneko, M. K.; Harada, H.; Kagawa, Y.; Konnai, S.; Kato, Y.
Publisher
Mary Ann Liebert, Inc., New Rochelle, USA
Citation
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2017, 36, 6, pp 243-250
Abstract

Feline oral squamous cell carcinoma (FOSCC) is a highly aggressive head and neck cancer in cats, but the molecular pathogenesis of this cancer is still uncertain. In this study, p16, p53, and pRb proteins were detected and quantified by immunohistochemistry in forty-three FOSCC primary tumors and...

Author(s)
Supsavhad, W.; Dirksen, W. P.; Hildreth, B. E., III; Rosol, T. J.
Publisher
MDPI AG, Basel, Switzerland
Citation
Veterinary Sciences, 2016, 3, 3, pp 18
Abstract

Oral squamous cell carcinoma (OSCC) is an aggressive and treatment-resistant malignancy in both feline and human patients. Recent work has demonstrated aberrant expression of fatty acid synthase (FASN) and an increased capacity for lipogenesis in human OSCC and other cancers. In human OSCC,...

Author(s)
Walz, J. Z.; Saha, J.; Arora, A.; Khammanivong, A.; O'Sullivan, M. G.; Dickerson, E. B.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 1, pp E99-E108
Abstract

Monocarboxylate transporters (MCTs) support tumour growth by regulating the transport of metabolites in the tumour microenvironment. High MCT1 or MCT4 expression is correlated with poor outcomes in human patients with head and neck squamous cell carcinoma (HNSCC). Recently, drugs targeting these...

Author(s)
Khammanivong, A.; Saha, J.; Spartz, A. K.; Sorenson, B. S.; Bush, A. G.; Korpela, D. M.; Gopalakrishnan, R.; Jonnalagadda, S.; Mereddy, V. R.; O'Brien, T. D.; Drewes, L. R.; Dickerson, E. B.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2020, 18, 3, pp 324-341
Abstract

Although oral squamous cell carcinomas (SCCs) are common in cats there are currently few prognostic markers for these cancers. This study used 52 feline oral SCCs to determine if prognosis can be predicted by the age or sex of the cat, the presence of bone within the diagnostic sample, or the...

Author(s)
Munday, J. S.; He YanYu; Aberdein, D.; Klobukowska, H. J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2019, 248, pp 64-70
Abstract

Feline Oral Squamous Cell Carcinoma (FOSCC) is among the most common tumors of the cat. It is characterized by high metastactic potential and local invasiveness in the most affected sites and often by a poor prognosis. Etiology includes many factors such as exposure to tobacco smoke wearing flea...

Author(s)
Licenziato, L.; Altamura, G.; Borzacchiello, G.
Publisher
Point Veterinaire Italie s.r.l., Milan, Italy
Citation
Summa, Animali da Compagnia, 2020, 37, 6, pp 39-43
Abstract

We aimed at the presentation of the current literature review on the oral neoplasms in cats, enriched in the own observations. These are usually squamous cell carcinomas of the gum epithelium. Oral squamous cell carcinoma (OSCC), the most common, locally invasive and metastatic tumor in cats,...

Author(s)
Sapierzyński, R.; Cygańska, M.
Publisher
Krajowa Izba Lekarsko Weterynaryjna, Warszawa, Poland
Citation
Życie Weterynaryjne, 2018, 93, 5, pp 332-337
Abstract

Feline oral squamous cell carcinoma (FOSCC) is characterized by high local invasiveness and early bone lysis. The late diagnosis largely limits the efficacy of therapy and increases treatment-related morbidity. The aim of this exploratory study was to assess the methylation pattern of 10 candidate...

Author(s)
Renzi, A.; Morandi, L.; Lenzi, J.; Rigillo, A.; Bettini, G.; Bellei, E.; Giacomini, A.; Tinto, D.; Sabattini, S.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2020, 18, 4, pp 825-837

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