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Abstract

Liver-type fatty acid-binding protein (L-FABP) is a biomarker for the early detection of renal diseases in humans. It is secreted along with cytotoxic oxidation products from proximal tubular epithelial cells under conditions of ischemia and/or oxidative stress. This study examined urinary L-FABP...

Author(s)
Katayama, M.; Miyazaki, T.; Ohata, K.; Oikawa, T.; Kamiie, J.; Sugaya, T.; Miyazaki, M.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 12, pp 1868-1872
Abstract

Previous work demonstrated renal fibrosis 70 days after a single unilateral in vivo renal ischemic event, but changes associated with a single episode of renal ischemia past this time are unknown. In this study, we evaluated renal function and structural changes 6 months after a 90-minute in vivo...

Author(s)
Brown, C. A.; Rissi, D. R.; Dickerson, V. M.; Davis, A. M.; Brown, S. A.; Schmiedt, C. W.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2019, 56, 4, pp 536-543
Abstract

The objectives of this study were to define the acute and chronic effects of 1-hour unilateral in vivo renal ischemia on renal function and histology in cats. Twenty-one adult purpose-bred research cats were anesthetized, and 1 kidney underwent renal artery and vein occlusion for 1 hour. Serum...

Author(s)
Schmiedt, C. W.; Brainard, B. M.; Hinson, W.; Brown, S. A.; Brown, C. A.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2016, 53, 1, pp 87-101
Abstract

Objectives: The study aims were to evaluate the feasibility of contrast-enhanced ultrasonography in feline renal transplant recipients in the post-transplantation period and to report findings in a case with presumptive delayed allograft ischemia. Methods: Cats were imaged postoperatively using...

Author(s)
Greenbarg, E. H.; Jiménez, D. A.; Nell, L. A.; Schmiedt, C. W.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2018, 20, 4, pp 393-398
Abstract

Chronic kidney disease (CKD) is the most common metabolic disease of domesticated cats, with most affected cats being geriatric (>12 years of age). The prevalence of CKD in cats exceeds that observed in dogs, and the frequency of the diagnosis of CKD in cats has increased in recent decades. Typical ...

Author(s)
Brown, C. A.; Elliott, J.; Schmiedt, C. W.; Brown, S. A.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2016, 53, 2, pp 309-326
Abstract

Sensitive markers to detect acute kidney injury (AKI) in cats are lacking. Kidney injury molecule-1 (KIM-1) is a promising marker of acute tubular injury in humans, and sequence and structure of feline KIM-1 have been determined. KIM-1 is shed into urine of cats with natural AKI. The objectives of...

Author(s)
Bland, S. K.; Schmiedt, C. W.; Clark, M. E.; DeLay, J.; Bienzle, D.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2017, 54, 3, pp 490-510
Abstract

Background: Renal ischemia/reperfusion injury is the most common cause of acute kidney injury, which frequent occurrence in critically ill patients. Objectives: The aim of this study was to investigate the role of Carvacrol (CARV) against bilateral ischemia reperfusion (I/R) in rats. Methods: Renal ...

Author(s)
Ozturk, H.; Cetİnkaya, A.; Duzcu, S. E.; Tekce, B. K.; Ozturk, H.
Publisher
Elsevier Masson SAS, Issy-les-Moulineaux, France
Citation
Biomedicine & Pharmacotherapy, 2018, 98, pp 656-661
AbstractFull Text

Background. The present work was designed to study the effects of methanolic stevia extracts and aerobic exercise and combination of both on renal I/R injury in male rats. Methods. 60 adult male Sprague-Dawley rats were subdivided into five equal groups as sham, control, exercise, stevia, and...

Author(s)
Elsaid, F. H.; Khalil, A. A.; Ibrahim, E. M.; Mansour, A.; Hussein, A. M.
Publisher
Wydawnictwo Akademii Rolniczej w Poznaniu, Poznań, Poland
Citation
Acta Scientiarum Polonorum - Technologia Alimentaria, 2019, 18, 3, pp 317-332
Abstract

Objective: To evaluate the effects of allogeneic mesenchymal stem cells (MSCs) in a model of ischemic acute kidney injury (AKI). Study design: Randomized controlled trial. Animals: Adult, purpose-bred research cats (n=15) and a historical reference group (n=3). Methods: Cats underwent unilateral,...

Author(s)
Rosselli, D. D.; Mumaw, J. L.; Dickerson, V.; Brown, C. A.; Brown, S. A.; Schmiedt, C. W.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2016, 108, pp 18-24
Abstract

The objective of this study was to evaluate the effect of 1 h, bilateral, warm ischemia-reperfusion kidney injury as a model of acute kidney injury in the cat. Four adult healthy cats underwent 60 min of bilateral, in vivo renal warm ischemia; three cats were sham operated controls. Kidney function ...

Author(s)
Schmiedt, C. W.; Nelson, S. A.; Brainard, B. M.; Brown, C. A.; Vandenplas, M.; Hurley, D. J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2012, 93, 2, pp 950-959

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