Neuromuscular diseases are characterized by a permanent or episodic peripheral motor neuron disorder, and result from lesions in one of elements of the motor unit: the motor neuron, the neuromuscular junction or the muscle fibres. The majority of hereditary neuromuscular diseases affect juveniles...

Clinical signs and histopathologic and ultrastructural features were consistent with those reported in globoid cell leukodystrophy in man, cat, and other breeds of dogs. The occurrence of the disorder in two clinically affected females from a related litter and a familial history of inbreeding...

Globoid leucodystrophy, a progressive demyelinating disease of the central and peripheral nervous systems, is reported in two female kittens; it resulted from inbreeding. The characteristic globoid cell reaction found in white matter of the central nervous system was consistent with that reported...

Information in this disease system overview will be expanded in the next edition of the Compendium. Please note that the list of diseases affecting...