This article summarizes the interpretation of coagulation screening tests and the clinical and laboratory features of feline factor XII deficiency (Hageman trait). In a case series of feline hereditary factor deficiencies diagnosed in the United States, the incidence of Hageman trait was...

The feline F12 gene was examined to identify a mutation associated with coagulation factor XII (FXII) deficiency in a litter of 6 cats, including 2 cats with severely reduced FXII activity (7.1 and 9.3%, respectively) and 4 cats with moderately reduced FXII activity (range 36.0 to 46.3%). Cats with ...

Coagulation factor XII (FXII) may be important in cardiovascular and inflammatory diseases. We have identified and characterized a naturally occurring mutation in the feline FXII gene that results in a mutant protein and enzymatic loss of activity. Feline intron/exon gene structure and sequence...

A case of bladder tamponade in a cat with coagulation factor XII deficiency. A 31/2-year-old castrated mixed-breed cat exhibited dysuria and was referred to the Animal Medical Center of Yamaguchi University, Japan. The cat had a history of feline lower urinary tract infection. Based on diagnostic...

Case summary: The current report describes thromboelastography (TEG) findings in two cats with factor XII (FXII) deficiency. The first cat was diagnosed with bilateral perinephric pseudocysts; hemostatic testing was performed prior to performing renal aspirates. The second cat was healthy;...

The Arthus reaction was studied in an animal model of Hageman-factor deficiency, Hageman trait cats, and in control cats with normal Hageman-factor activity. At three time points, there was a significant decrease in the size of the cutaneous Arthus reaction to chicken red blood cells in biopsies...

A commercially available, disposable blade in a spring-loaded cassette was used to measure oral mucosa bleeding times (OMBT) of ketamine/acepromazine-anaesthetized cats. The OMBT were determined in 7 cats homozygous for Chediak-Higashi syndrome (CHS), 6 cats heterozygous for CHS and 5 cats...

Objective: To describe a case of spontaneous epistaxis in a cat with type 3 von Willebrand disease (VWD) and detail the successful management of hemorrhagic episodes on 2 occasions. Case summary: A 3.6 kg, 1-year-old, female mixed-breed domestic long-haired cat presented for spontaneous epistaxis....

Cats with spontaneous bleeding due to hemostatic disorders are less often presented compared to dogs. The typical clinical signs of secondary hemostatic disorders (coagulopathies) are bleeding into body cavities, into joints, hematoma formation, and delayed bleeding after trauma. If a coagulopathy...

A male cat suffered from a severe haemorrhagic disorder manifesting as deep, partly infected cutaneous haematomas, enhanced and prolonged bleeding after injuries and subsequent lameness at several occasions. Bleeding resulted in severe anaemia with haematocrit falling to as low as 0.10 L/L....