Objectives: The aim of the study was to determine if amantadine improves owner-identified mobility impairment and quality of life associated with osteoarthritis in cats. Methods: Using a blinded, placebo-controlled, randomized, crossover design, 13 healthy client-owned cats with clinical and...

This case report describes the presentation of neuropathic pain in cats, highlights the recognition of clinical signs such as allodynia and hyperalgesia and describes treatment with amantadine as part of an analgesic protocol for neuropathic pain relief. A cat found after a road traffic accident...

A non-steroidal anti-inflammatory drug (NSAID) is the first-line drug therapy for cats and dogs with chronic pain. If NSAIDs are not tolerated, are contraindicated or become ineffective, there are few alternative drug treatments available to try. Amantadine, a dopamine agonist and anti-viral drug...

OA represents whole-organ failure of the synovial joint(s) and is common in cats. The progressive deterioration of one or more components of the joint is associated with pain, inflammation, peripheral and/or central sensitisation, and decreased mobility, which ultimately impact activity and quality ...

This study examined the effect of amantadine, an N-methyl-D-aspartate receptor antagonist, on the thermal antinociceptive effect of oxymorphone in cats. Six adult healthy cats were used. After baseline thermal threshold determinations, oxymorphone was administered intravenously to maintain plasma...

This study reports the pharmacokinetics of amantadine in cats, after both i.v. and oral administration. Six healthy adult domestic shorthair female cats were used. Amantadine HCl (5 mg/kg, equivalent to 4 mg/kg amantadine base) was administered either intravenously or orally in a crossover...

The clinical aspects, causes, diagnosis, and treatment of osteoarthritis in cats are presented.

Feline infectious peritonitis virus (FIPV), a coronavirus that causes a lethal chronic disease in cats, enters feline monocytes via endocytosis. In this study, the pathway of internalization is characterized by evaluating the effect of chemical inhibitors and/or expression of dominant-negative (DN) ...

Feline infectious peritonitis virus (FIP virus: FIPV), a feline coronavirus of the family Coronaviridae, causes a fatal disease called FIP in wild and domestic cat species. The genome of coronaviruses encodes a hydrophobic transmembrane protein, the envelope (E) protein. The E protein possesses ion ...

This article discusses the different choices of take-home pain medication for feline patients. Focus is given on the management of acute and chronic pain in cats and dosage of drugs used such as buprenorphine, tramadol hydrochloride, gabapentin, amantadine hydrochloride and meloxicam. The adverse...