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Abstract

Feline infectious peritonitis virus (FIPV) causes a severe, immune-mediated disease called FIP in domestic and wild cats. It is unclear whether FIP transmits from cat to cat through the oral route of FIPV infection, and the reason for this includes that FIP is caused by oral inoculation with some...

Author(s)
Takano, T.; Yamada, S.; Doki, T.; Hohdatsu, T.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 6, pp 911-915
Abstract

Feline infectious peritonitis virus (FIPV) replication in macrophages/monocytes induced tumor necrosis factor (TNF)-alpha production, and that the TNF-alpha produced was involved in aggravating the pathology of FIP. We previously reported the preparation of a feline TNF-alpha...

Author(s)
Doki, T.; Takano, T.; Kawagoe, K.; Kito, A.; Hohdatsu, T.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2016, 104, pp 17-23
Abstract

Feline coronavirus (FCoV) has been classified into two biotypes: avirulent feline coronavirus (feline enteric coronavirus: FECV) and virulent feline coronavirus (feline infectious peritonitis virus: FIPV). In FIPV infection, antibody-dependent enhancement (ADE) has been reported and was shown to be ...

Author(s)
Takano, T.; Nakaguchi, M.; Doki, T.; Hohdatsu, T.
Publisher
Springer-Wien, Wien, Austria
Citation
Archives of Virology, 2017, 162, 11, pp 3339-3345
Abstract

Feline infectious peritonitis (FIP) is a fatal inflammatory disease caused by FIP virus infection. Feline tumor necrosis factor (fTNF)-alpha is closely involved in the aggravation of FIP pathology. We previously described the preparation of neutralizing mouse anti-fTNF-alpha monoclonal antibody...

Author(s)
Doki, T.; Takano, T.; Hohdatsu, T.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2016, 78, 9, pp 1447-1455
Abstract

Feline infectious peritonitis (FIP) is a feline coronavirus (FCoV)-induced fatal disease in wild and domestic cats. FCoV exists in two serotypes. Type I FCoV is the dominant serotype worldwide. Therefore, it is necessary to develop antiviral drugs against type I FCoV infection. We previously...

Author(s)
Takano, T.; Endoh, M.; Fukatsu, H.; Sakurada, H.; Doki, T.; Hohdatsu, T.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Antiviral Research, 2017, 145, pp 96-102
Abstract

Feline infectious peritonitis virus (FIPV) can cause a lethal disease in cats, feline infectious peritonitis (FIP). A therapeutic drug that is effective against FIP has not yet been developed. Peptides based on viral protein amino acid sequences have recently been attracting attention as new...

Author(s)
Doki, T.; Takano, T.; Koyama, Y.; Hohdatsu, T.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Virus Research, 2015, 204, pp 13-20
Abstract

Feline infectious peritonitis virus (FIP virus: FIPV), a feline coronavirus of the family Coronaviridae, causes a fatal disease called FIP in wild and domestic cat species. The genome of coronaviruses encodes a hydrophobic transmembrane protein, the envelope (E) protein. The E protein possesses ion ...

Author(s)
Takano, T.; Nakano, K.; Doki, T.; Hohdatsu, T.
Publisher
Springer-Wien, Wien, Austria
Citation
Archives of Virology, 2015, 160, 5, pp 1163-1170
Abstract

Feline coronaviruses (FCoVs) are the causative agents of severe systemic disease (feline infectious peritonitis: FIP) in domestic and wild cats. FCoVs have been classified into serotypes I and II. Type I FCoV is the dominant serotype (approximately 70-90%) worldwide. Therefore, it is necessary to...

Author(s)
Takano, T.; Akiyama, M.; Doki, T.; Hohdatsu, T.
Publisher
BioMed Central Ltd, London, UK
Citation
Veterinary Research, 2019, 50, 5, pp (18 January 2019)
Abstract

Feline infectious peritonitis (FIP) is a feline coronavirus (FCoV)-induced fatal disease in wild and domestic cats. There are two FCoV serotypes. Both type I and II FCoV can replicate in Felis catus whole fetus (fcwf)-4 cells, but the replicability of type I FCoV in feline cell lines is lower than...

Author(s)
Doki, T.; Yabe, M.; Takano, T.; Hohdatsu, T.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2018, 120, pp 57-62
Abstract

Feline infectious peritonitis virus (FIP virus: FIPV) causes a fatal disease in wild and domestic cats. The development of an FIP-preventive vaccine requires an antigen that does not induce antibody-dependent enhancement, and T helper (Th)1 activity plays an important role in protect against FIPV...

Author(s)
Takano, T.; Morioka, H.; Gomi, K.; Tomizawa, K.; Doki, T.; Hohdatsu, T.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Vaccine, 2014, 32, 16, pp 1834-1840

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