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Abstract

Background: Currently, no test can accurately predict the development of azotemia after treatment of hyperthyroidism. Serum cystatin C concentrations (sCysC) might be less influenced by changes in body muscle mass and so better indicate the presence of concurrent chronic kidney disease (CKD) in ...

Author(s)
Williams, T. L.; Dillon, H.; Elliott, J.; Syme, H. M.; Archer, J.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2016, 30, 4, pp 1083-1089
Abstract

Background: Hyperthyroidism is common in older cats, which necessitates frequent screening of serum total thyroxine (TT4) concentrations. Fast, cheap, and reliable methods to measure TT4 in cats are needed. Objectives: The purpose of the study was the validation of a human TT4 enzyme immunoassay...

Author(s)
Williams, T. L.; Archer, J.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Veterinary Clinical Pathology, 2016, 45, 1, pp 148-153
Abstract

Our objective was to identify if changes in serum protein concentrations occur in hyperthyroidism and to assess their association with the development of azotaemia following treatment. Initially non-azotaemic hyperthyroid cats and healthy older cats were included. Serum concentrations of protein...

Author(s)
Williams, T. L.; Elliott, J.; Syme, H. M.; Archer, J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2017, 115, pp 412-417
Abstract

Many hyperthyroid cats develop azotaemic chronic kidney disease (aCKD) following treatment, which has led to the hypothesis that hyperthyroidism might be detrimental to renal function. Renin-angiotensin-aldosterone system (RAAS) activation occurs in hyperthyroidism, which could cause peri-tubular...

Author(s)
Williams, T. L.; Elliott, J.; Syme, H. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2014, 96, 3, pp 436-441
Abstract

Background: Iatrogenic hypothyroidism can occur after treatment of hyperthyroidism, and is correlated with a reduced glomerular filtration rate in humans and dogs. Hypothesis: Cats with iatrogenic hypothyroidism after treatment for hyperthyroidism will have a greater incidence of azotemia than...

Author(s)
Williams, T. L.; Elliott, J.; Syme, H. M.
Publisher
Blackwell Publishing Ltd, Oxford, UK
Citation
Journal of Veterinary Internal Medicine, 2010, 24, 5, pp 1086-1092
Abstract

Background: Hyperthyroidism complicates the diagnosis of chronic kidney disease (CKD) as it increases glomerular filtration rate. No practical and reliable means for identifying those cats that will develop azotemia after treatment for hyperthyroidism has been identified. Hyperthyroidism is...

Author(s)
Williams, T. L.; Peak, K. J.; Brodbelt, D.; Elliott, J.; Syme, H. M.
Publisher
Blackwell Publishing Ltd, Oxford, UK
Citation
Journal of Veterinary Internal Medicine, 2010, 24, 4, pp 863-869
Abstract

Background: Hypertension is present in some hyperthyroid cats at diagnosis or can develop after treatment for hyperthyroidism. Activation of the renin-angiotensin-aldosterone system (RAAS) could be involved in the pathogenesis of hypertension. Hypothesis: Hyperthyroid cats that develop hypertension ...

Author(s)
Williams, T. L.; Elliott, J.; Syme, H. M.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2013, 27, 3, pp 522-529
Abstract

Objective: To investigate possible pathophysiological mechanisms (reduced plasma calcitriol concentrations and/or presence of concurrent or masked chronic kidney disease) for hypocalcaemiain hyperthyroid cats. Methods: Prospective cohort study. Routine plasma biochemical parameters, plasma...

Author(s)
Williams, T. L.; Elliott, J.; Berry, J.; Syme, H. M.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Small Animal Practice, 2013, 54, 7, pp 367-373
Abstract

Background: Iatrogenic hypothyroidism is associated with an increased incidence of azotemia after treatment of hyperthyroidism, and decreased survival time in azotemic hyperthyroid cats. Hypothesis: Restoration of euthyroidism will decrease plasma creatinine concentrations. Animals: Nineteen...

Author(s)
Williams, T. L.; Elliott, J.; Syme, H. M.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2014, 28, 4, pp 1251-1255
Abstract

Objectives: To evaluate calcium and phosphate homeostasis in hyperthyroid cats and determine if plasma parathyroid hormone and fibroblast growth factor-23 are associated with the presence of azotaemic chronic kidney disease and/or have prognostic significance. Methods: Retrospective cohort study....

Author(s)
Williams, T. L.; Elliott, J.; Syme, H. M.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Small Animal Practice, 2012, 53, 10, pp 561-571