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Abstract

NKX3.1/C-MYC cross-regulation has been reported in the normal human prostate, and loss of NKX3.1 and gain of C-MYC seem to be important events in prostate cancer development and progression. The dog can be an interesting model for human prostatic disease, and yet only one previous research study...

Author(s)
Fonseca-Alves, C. E.; Kobayashi, P. E.; Laufer-Amorim, R.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2018, 118, pp 365-370
Abstract

Prostate cancer is a heterogeneous disease with high levels of clinical and gene heterogeneity, consequently offering several targets for therapy. Dogs with naturally occurring prostate cancer are useful models for molecular investigations and studying new treatment efficacy. Three genes and...

Author(s)
Kobayashi, P. E.; Fonseca-Alves, C. E.; Rivera-Calderón, L. G.; Carvalho, M.; Kuasne, H.; Rogatto, S. R.; Laufer-Amorim, R.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2018, 118, pp 254-261
AbstractFull Text

Gene expression of CDKN1A, CDKN1B, and TP53, and immunostaining of p21, p27 and p53 were evaluated to verify the role of these cell cycle inhibitors in canine prostates with proliferative inflammatory atrophy-PIA and prostatic carcinoma-PC. Seventy samples, 15 normal, 30PIA and 25PC. Regarding...

Author(s)
Faleiro, M. B. R.; Cintra, L. C.; Jesuino, R. S. A.; Damasceno, A. D.; Moura, V. M. B. D.
Publisher
FEPMVZ - Editora, Belo Horizonte, Brazil
Citation
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2018, 70, 1, pp 82-92
AbstractFull Text

All dogs may experience prostatic disease, but particular care should be addressed to breeding dogs, in which prostatic affection may lead to decrease in semen quality and fertility. The two most frequent prostatic diseases in dogs are benign prostatic hyperplasia (BPH) and prostatitis. BPH therapy ...

Author(s)
Cunto, M.; Ballotta, G.
Publisher
Edizioni SCIVAC, Cremona, Italy
Citation
Veterinaria (Cremona), 2018, 32, 2, pp 85-95
AbstractFull Text

In small animal practice, prostatic diseases are encountered frequently, especially in old dogs. The most common prostatic disease is the benign prostatic hyperplasia followed by prostatitis, prostatic neoplasia and prostate squamous metaplasia. These diseases do not have pathognomonic symptoms,...

Author(s)
Ballotta, G.; Cunto, M.
Publisher
Edizioni SCIVAC, Cremona, Italy
Citation
Veterinaria (Cremona), 2018, 32, 2, pp 73-82
Abstract

Proliferative inflammatory atrophy (PIA), which is comprised of highly proliferative but atrophic prostate epithelial cells in association with chronic inflammation, is considered a risk lesion for prostate cancer in men, while its role in canine prostate carcinogenesis is still unknown. We...

Author(s)
Palmieri, C.; Story, M.; Lean, F. Z. X.; Akter, S. H.; Grieco, V.; Marzo, A. M. de
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Comparative Pathology, 2018, 158, pp 1-5
AbstractFull Text

Gene expression of ErbB1 and ErbB2, and immunostaining of EGFR (Her1) and Her2 (c-erbB-2) were evaluated in this study to ascertain whether these receptors are involved in the evolution of canine premalignant and malignant prostatic lesions, as proliferative inflammatory atrophy (PIA) and prostatic ...

Author(s)
Faleiro, M. B. R.; Cintra, L. C.; Jesuino, R. S. A.; Araújo, E. G. de; Rocha, R. M.; Moura, V. M. B. D. de
Publisher
Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, Brazil
Citation
Ciência Rural, 2017, 47, 12, pp e20170085
Abstract

Background: c-KIT expression has been related to bone metastasis in human prostate cancer, but whether c-KIT expression can be similarly classified in canine prostatic tissue is unknown. This study assessed c-KIT and Ki67 expression in canine prostate cancer (PC). c-KIT gene and protein...

Author(s)
Fonseca-Alves, C. E.; Kobayashi, P. E.; Palmieri, C.; Laufer-Amorim, R.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2017, 13, 380, pp (6 December 2017)
Abstract

Recent discovery of the BRAF V595E mutation in a variety of canine cancers indicates that mutant BRAF may represent a novel therapeutic target. Presence of RAS mutations is associated with poor tumour response to BRAF inhibition but has not been investigated in BRAF-mutated canine cancers. The aim...

Author(s)
Mochizuki, H.; Breen, M.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2017, 15, 4, pp 1598-1605
AbstractFull Text

A dog with a history of diarrhea and dyschezia exhibited an oval-shaped, soft-tissue opacity mass in the abdomen on radiographs. CT examination revealed a large fluid-filled structure displacing the urinary bladder, prostate, and colon. The mass had continuity with the prostate; therefore, it was...

Author(s)
Kim HyeJin; Kim SuYeon; Kim SeongSoo; Yun SooKyung; Lee JeoSoon; Hong SungKyun; Kim WanHee; Kim YongBaek; Yoon JungHee; Choi MinCheol
Publisher
Korean Society of Veterinary Science, Seoul, Korea Republic
Citation
Journal of Veterinary Science, 2017, 18, 4, pp 559-561

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