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Abstract

Next-generation sequencing (NGS) has opened up the possibility of detecting new viruses in unresolved diseases. Recently, astrovirus brain infections have been identified in neurologically diseased humans and animals by NGS, among them bovine astrovirus (BoAstV) CH13/NeuroS1, which has been found...

Author(s)
Selimovic-Hamza, S.; Boujon, C. L.; Hilbe, M.; Oevermann, A.; Seuberlich, T.
Publisher
MDPI AG, Basel, Switzerland
Citation
Viruses, 2017, 9, 1, pp 12
Abstract

Encephalitis is a frequently diagnosed condition in cattle with neurological diseases. Many affected animals present with a nonsuppurative inflammatory reaction pattern in the brain. While this pattern supports a viral etiology, the causative pathogen remains unknown in a large proportion of cases. ...

Author(s)
Bouzalas, I. G.; Wüthrich, D.; Walland, J.; Drögemüller, C.; Zurbriggen, A.; Vandevelde, M.; Oevermann, A.; Bruggmann, R.; Seuberlich, T.
Publisher
American Society for Microbiology (ASM), Washington, USA
Citation
Journal of Clinical Microbiology, 2014, 52, 9, pp 3318-3324
Abstract

Bovine astrovirus (BoAstV) was identified by reverse transcriptase polymerase chain reaction on brain tissue of 2 feedlot cattle that died of non-suppurative encephalitis. Sequencing demonstrated a high degree of identity with neurotropic US and Swiss BoAstV strains. To our knowledge, this is the...

Author(s)
Spinato, M. T.; Vince, A.; Cai, H.; Ojkic, D.
Publisher
Canadian Veterinary Medical Association, Ottawa, Canada
Citation
Canadian Veterinary Journal, 2017, 58, 6, pp 607-609
Abstract

Non-suppurative encephalitis is one of the most frequent pathological diagnosis in cattle with neurological disease, but there is a gap in the knowledge on disease-associated pathogens. In order to identify viruses that are associated with non-suppurative encephalitis in cattle, we used a viral...

Author(s)
Wüthrich, D.; Boujon, C. L.; Truchet, L.; Selimovic-Hamza, S.; Oevermann, A.; Bouzalas, I. G.; Bruggmann, R.; Seuberlich, T.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Virology, 2016, 493, pp 22-30
Abstract

Members of the Astroviridae family are best known to cause diarrhea in different mammalian species. Lately, some strains have been associated with encephalitis in humans, minks and cattle. In this study, we developed an immunohistochemistry (IHC) procedure for the detection of a neurotropic bovine ...

Author(s)
Boujon, C. L.; Selimovic-Hamza, S.; Bouzalas, I.; Seuberlich, T.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Journal of Virological Methods, 2017, 239, pp 26-33
Abstract

The etiology of viral encephalitis in cattle often remains unresolved, posing a potential risk for animal and human health. In metagenomics studies of cattle with bovine non-suppurative encephalitis, parainfluenza virus 5 (PIV5) was identified in three brain samples. Interestingly, in two of these...

Author(s)
Hierweger, M. M.; Werder, S.; Seuberlich, T.
Publisher
MDPI AG, Basel, Switzerland
Citation
International Journal of Molecular Sciences, 2020, 21, 2,
Abstract

Encephalitis can be caused by several infectious agents, including bacteria, fungi, parasites and viruses. In many cases, the causative agent cannot be identified, because the pathogens are unknown or detection methods are not routinely available. In our case, a 15-month-old cow developed central...

Author(s)
Schlottau, K.; Schulze, C.; Bilk, S.; Hanke, D.; Höper, D.; Beer, M.; Hoffmann, B.
Publisher
Wiley-Blackwell, Berlin, Germany
Citation
Transboundary and Emerging Diseases, 2016, 63, 3, pp 253-259
Abstract

In June 2013, a 4-year-old Welsh Mountain ewe and in March 2014 a 10-day-old lamb of the same breed and the same flock presented progressive neurological signs including depressed sensorium, tremor, and unusual behaviour. Neuropathological examination of the brain and spinal cord detected ...

Author(s)
Pfaff, F.; Schlottau, K.; Scholes, S.; Courtenay, A.; Hoffmann, B.; Höper, D.; Beer, M.
Publisher
Wiley, Berlin, Germany
Citation
Transboundary and Emerging Diseases, 2017, 64, 3, pp 677-682
Abstract

In this study, starting from nucleic acids purified from the brain tissue, Nanopore technology was used to identify the etiological agent of severe neurological signs observed in a cow which was immediately slaughtered. Histological examination revealed acute non-suppurative encephalomyelitis...

Author(s)
Zaccaria, G.; Lorusso, A.; Hierweger, M. M.; Malatesta, D.; Defourny, S. V. P.; Ruggeri, F.; Cammà, C.; Ricci, P.; Domenico, M. di; Rinaldi, A.; Decaro, N.; D'Alterio, N.; Petrini, A.; Seuberlich, T.; Marcacci, M.
Publisher
MDPI AG, Basel, Switzerland
Citation
Viruses, 2020, 12, 5,
Abstract

Background: Evidence of neurotropic astroviruses has been established using novel genetic methods in cattle suffering from viral encephalitis of previously unknown origin. Objectives: To describe the clinical signs observed in cattle with astrovirus-associated encephalitis. Animals: Eight cattle (4 ...

Author(s)
Deiss, R.; Selimovic-Hamza, S.; Seuberlich, T.; Meylan, M.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2017, 31, 4, pp 1209-1214

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