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Abstract

African animal trypanosomiasis is a major cause of mortality and economic losses for the livestock industry in Nigeria. Chemotherapy has been the most reliable option for cattle herders, and the most commonly found drug on the market is diminazene aceturate. To ascertain the long-term efficacy of...

Author(s)
Odeniran, P. O.; Macleod, E. T.; Ademola, I. O.; Welburn, S. C.
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Tropical Animal Health and Production, 2019, 51, 7, pp 2091-2094
Abstract

The validation of a fluorescence-based high-throughput screening (HTS) assay for determining the efficacies of large chemical libraries against Babesia divergens (bovine strain) in in vitro cultures was evaluated in this study. Hematocrits (HCTs) of 2.5%, 5%, and 10% were used for the in vitro...

Author(s)
Rizk, M. A.; El-Sayed, S. A. E.; AbouLaila, M.; Tuvshintulga, B.; Yokoyama, N.; Igarashi, I.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2016, 227, pp 93-97
Abstract

There is an innovative approach to discovering and developing novel potent and safe anti-Babesia and anti-Theileria agents for the control of animal piroplasmosis. Large-scale screening of 400 compounds from a Malaria Box (a treasure trove of 400 diverse compounds with antimalarial activity has...

Author(s)
Rizk, M. A.; El-Sayed, S. A. E.; El-Khodery, S.; Yokoyama, N.; Igarashi, I.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2019, 274, pp 108895
Abstract

Post mortem examinations were performed on the carcasses of two male White Fulani calves that reportedly died within a herd of about 45 cattle. Similar deaths were recorded in three other calves of the same age bracket (8-13 weeks) within a 5-day period about two weeks ago but no post mortem...

Author(s)
Audu, Z.; Abalaka, S. E.
Publisher
Springer, New Delhi, India
Citation
Journal of Parasitic Diseases, 2019, 43, 4, pp 597-600
Abstract

A three years old Jersey cross bred cow was presented with the signs of lympahadenopathy and catarrhal diarrhoea. Examination of faecal and peripheral blood smears revealed Eimeria spp. and Babesia bigemina. Haemato-biochemical analysis revealed alterations in the serum biochemical values. The case ...

Author(s)
Saravanan, S.; Mohanapriya, T.; PonnuSwamy, K. K.; Enbavelan, P. A.; SundaraRajan, R. C.; Ramprabhu, R.
Publisher
Indian Veterinary Association, Chennai, India
Citation
Indian Veterinary Journal, 2019, 96, 9, pp 76-77
Abstract

Objective: To evaluate the antipiroplasmic activities of methanolic extract of Olea europaea (MOE) and acetonic extract of Acacia laeta (AAL) against Babesia and Theileria parasites in vitro and evaluate the chemotherapeutic effects of these extracts against Babesia (B.) microti in vivo. Methods:...

Author(s)
Beshbishy, A. M.; Batiha, G. E.; Adeyemi, O. S.; Yokoyama, N.; Igarashi, I.
Publisher
Medknow Publications, Mumbai, India
Citation
Asian Pacific Journal of Tropical Medicine, 2019, 12, 9, pp 425-434
Abstract

The treatment of bovine and equine piroplasmosis is limited to diminazene aceturate (DA) and imidocarb dipropionate. To address this challenge, we need to explore novel drug compounds and targets. Topoisomerases are potential drug targets because they play a vital role in solving topological errors ...

Author(s)
Tayebwa, D. S.; Bumduuren Tuvshintulga; Guswanto, A.; Nugraha, A. B.; Batiha, G. E.; Gantuya, S.; Rizk, M. A.; Vudriko, P.; Thillaiampalam Sivakumar; Yokoyama, N.; Igarashi, I.
Publisher
Elsevier GmbH, München, Germany
Citation
Ticks and Tick-borne Diseases, 2018, 9, 5, pp 1192-1201
Abstract

A 5 years old crossbred cow was brought to the Veterinary Clinical Complex of Lala Lajpat Rai University of Veterinary and Animal Sciences Hisar with history of progressive weakness, pale mucous membrane, anorexia, high fever (105°F), tachycardia, laboured breathing and coffee coloured urine....

Author(s)
Chandratre, G. A.; Jangir, B. L.; Maneesh Sharma; Jakhar, K. K.; Tarun Kumar
Publisher
Springer, New Delhi, India
Citation
Journal of Parasitic Diseases, 2018, 42, 4, pp 643-645
Abstract

A rapid and accurate assay for evaluating antibabesial drugs on a large scale is required for the discovery of novel chemotherapeutic agents against Babesia parasites. In the current study, we evaluated the usefulness of a fluorescence-based assay for determining the efficacies of antibabesial...

Author(s)
Rizk, M. A.; El-Sayed, S. A. E. S.; Terkawi, M. A.; Youssef, M. A.; El-Said, E. S. E. S.; Elsayed, G.; El-Khodery, S.; El-Ashker, M.; Elsify, A.; Omar, M.; Salama, A.; Yokoyama, N.; Igarashi, I.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2015, 10, 4, pp e0125276
Abstract

Since its production in the 1980s, ivermectin (IVM) has been used indiscriminately and the selection pressure to which bovine gastrointestinal nematodes have been exposed has been intense, resulting in considerable economic losses due to parasitic resistance. One possibility for the control of...

Author(s)
Heckler, R. P.; Almeida, G. D.; Santos, L. B.; Borges, D. G. L.; Neves, J. P. L.; Onizuka, M. K. V.; Borges, F. A.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2014, 205, 3/4, pp 638-645

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