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Abstract

Background: Human onchocerciasis or river blindness, caused by the filarial nematode Onchocerca volvulus, is currently controlled using the microfilaricidal drug, ivermectin. However, ivermectin does not kill adult O. volvulus, and in areas with less than 65% ivermectin coverage of the population,...

Author(s)
Bronsvoort, B. M. de C.; Makepeace, B. L.; Renz, A.; Tanya, V. N.; Fleckenstein, L.; Ekale, D.; Trees, A. J.
Publisher
BioMed Central Ltd, London, UK
Citation
Parasites and Vectors, 2008, 1, 18, pp (20 June 2008)
Abstract

Human onchocerciasis (river blindness), caused by the filarial nematode Onchocerca volvulus, has been successfully controlled by a single drug, ivermectin, for over 25 years. Ivermectin prevents the disease symptoms of severe itching and visual impairment by killing the microfilarial stage, but...

Author(s)
Bah, G. S.; Tanya, V. N.; Makepeace, B. L.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2015, 212, 1/2, pp 25-34
Abstract

Background: Ivermectin (Mectizan) is being widely used in the control of human onchocerciasis (Onchoverca volvulus) because of its potent effect on microfilariae. Human studies have suggested that, at the standard dose of 150 µg/kg, an annual treatment schedule of ivermectin reversibly interferes...

Author(s)
Bronsvoort, B. M. de C.; Renz, A.; Tchakouté, V.; Tanya, V. N.; Ekale, D.; Trees, A. J.
Publisher
BioMed Central Ltd, London, UK
Citation
Filaria Journal, 2005, 4, 8, pp (08 August 2005)
Abstract

Human onchocerciasis, caused by the filarial nematode Onchocerca volvulus, is controlled almost exclusively by the drug ivermectin, which prevents pathology by targeting the microfilariae. However, this reliance on a single control tool has led to interest in vaccination as a potentially...

Author(s)
Makepeace, B. L.; Jensen, S. A.; Laney, S. J.; Nfon, C. K.; Njongmeta, L. M.; Tanya, V. N.; Williams, S. A.; Bianco, A. E.; Trees, A. J.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS Neglected Tropical Diseases, 2009, 3, 11, pp e544

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