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Abstract

Background: Sebaceous adenitis (SA) and Addison's disease (AD) increased rapidly in incidence among Standard Poodles after the mid-twentieth century. Previous attempts to identify specific genetic causes using genome wide association studies and interrogation of the dog leukocyte antigen (DLA)...

Author(s)
Pedersen, N. C.; Brucker, L.; Tessier, N. G.; Liu HongWei; Penedo, M. C. T.; Hughes, S.; Oberbauer, A.; Sacks, B.
Publisher
BioMed Central Ltd, London, UK
Citation
Canine Genetics and Epidemiology, 2015, 2, 14, pp (27 August 2015)
Abstract

Primary hypoadrenocorticism, also known as Addison's disease, is an autoimmune disorder leading to the destruction of the adrenal cortex and subsequent loss of glucocorticoid and mineralocorticoid hormones. The disease is prevalent in Standard Poodles and is believed to be highly heritable in the...

Author(s)
Friedenberg, S. G.; Lunn, K. F.; Meurs, K. M.
Publisher
Springer, New York, USA
Citation
Mammalian Genome, 2017, 28, 1/2, pp 56-65
Abstract

As crossbred dogs gain in popularity, how they express inherited behaviour traits in comparison to their purebred constituent breeds is of interest. We investigated behaviours exhibited by crossbred dogs by focusing on the popular Goldendoodle and Labradoodle crossbreds and comparing them to their...

Author(s)
Shouldice, V. L.; Edwards, A. M.; Serpell, J. A.; Niel, L.; Robinson, J. A. B.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2019, 9, 12, pp 1162
Abstract

In a genetically heterogenous French breed, 181 individuals (105 females, 76 males; 146 miniature poodles, 32 standards, 2 toy and 1 giant), aged from 0.5 to 14 years, underwent an ophthalmological examination to look for cataract lesions. Electroretinography (ERG) has been performed to identify...

Author(s)
Chaudieu, G.
Publisher
Elsevier Masson, Issy-les Moulineaux Cedex, France
Citation
Revue Vétérinaire Clinique, 2019, 54, 2, pp 69-77
Abstract

Identifying regions of artificial selection within dog breeds may provide insights into genetic variation that underlies breed-specific traits or diseases - particularly if these traits or disease predispositions are fixed within a breed. In this study, we searched for runs of homozygosity (ROH)...

Author(s)
Friedenberg, S. G.; Meurs, K. M.; Mackay, T. F. C.
Publisher
Springer, New York, USA
Citation
Mammalian Genome, 2016, 27, 11/12, pp 599-609
Abstract

Addison's disease (AD) is a life-threatening endocrine disorder that occurs spontaneously in both humans and dogs. Associations between MHC class II genes and AD have been shown in several human studies. Our goal was to identify MHC class II associations with AD in a large population of Standard ...

Author(s)
Treeful, A. E.; Rendahl, A. K.; Friedenberg, S. G.
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Immunogenetics, 2019, 71, 5/6, pp 373-382
Abstract

Myxomatous mitral valve disease (MMVD) is the most common cardiovascular disease in the dog. The natural history of the disease is wide ranging and includes patients without clinical signs as well as those with significant clinical consequences from cardiac arrhythmias, pulmonary hypertension...

Author(s)
Meurs, K. M.; Adin, D.; O'Donnell, K.; Keene, B. W.; Atkins, C. E.; DeFrancesco, T.; Tou, S.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2019, 244, pp 94-97
Abstract

Naturally occurring hypoadrenocorticism (Addison's disease) is uncommon, with an estimated prevalence in the canine population between 0.06% and 0.28%. This retrospective study evaluated the prevalence and clinical features of hypoadrenocorticism in Great Pyrenees (GP) dogs presented to the Centre...

Author(s)
Decôme, M.; Blais, M. C.
Publisher
Canadian Veterinary Medical Association, Ottawa, Canada
Citation
Canadian Veterinary Journal, 2017, 58, 10, pp 1093-1099
Abstract

Behavioral problems occur frequently in dogs and represent a significant threat to dog welfare. Anxiety, phobias, and fears comprise most of the canine behavioral conditions. The identification of an association between specific behavioral phenotypes and genetic variants of candidate genes would be ...

Author(s)
Bellamy, K. K. L.; Storengen, L. M.; Handegård, K. W.; Arnet, E. F.; Prestrud, K. W.; Overall, K. L.; Lingaas, F.
Publisher
Elsevier, New York, USA
Citation
Journal of Veterinary Behavior: Clinical Applications and Research, 2018, 27, pp 67-73
Abstract

Degenerative myelopathy is a severe and progressive neurodegenerative disease and, in the majority of breeds, is associated with the c.118 G>A substitution in exon 2 of the canine superoxide dismutase 1 (SOD1) gene. Our laboratories have been engaged in determining the cause of many discordant...

Author(s)
Turba, M. E.; Loechel, R.; Rombolà, E.; Gandini, G.; Gentilini, F.
Publisher
Wiley, Oxford, UK
Citation
Animal Genetics, 2017, 48, 3, pp 365-368

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