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Abstract

Whole exome sequencing (WES) has become a common tool for identifying genetic causes of human inherited disorders, and it has also recently been applied to canine genome research. We conducted WES analysis of neuroaxonal dystrophy (NAD), a neurodegenerative disease that sporadically occurs...

Author(s)
Tsuboi, M.; Watanabe, M.; Nibe, K.; Yoshimi, N.; Kato, A.; Sakaguchi, M.; Yamato, O.; Tanaka, M.; Kuwamura, M.; Kushida, K.; Ishikura, T.; Harada, T.; Chambers, J. K.; Sugano, S.; Uchida, K.; Nakayama, H.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2017, 12, 1, pp e0169002
Abstract

Neuroaxonal dystrophy (NAD) is a neurodegenerative disease characterized by severe axonal swelling (spheroids) throughout the nervous system. In dogs, NAD has been reported in several breeds and a missense mutation in PLA2 G6 gene has recently been identified in the Papillon dog NAD. Here we...

Author(s)
Tanaka, M.; Yamaguchi, S.; Akiyoshi, H.; Tsuboi, M.; Uchida, K.; Izawa, T.; Yamate, J.; Kuwamura, M.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2017, 79, 12, pp 1927-1930
Abstract

Background: An autosomal recessive, rapidly progressive degenerative neuropathy known as infantile neuroaxonal dystrophy (NAD) was originally reported in Papillion puppies in 1995. In 2015, a causative missense variant in the PLA2G6 gene was identified in three affected puppies. Archived samples...

Author(s)
Raj, K.; Giger, U.
Publisher
BioMed Central Ltd, London, UK
Citation
Canine Medicine and Genetics, 2020, 7, 17, pp (30 November 2020)
Abstract

Recurrent outbreaks of sudden death and bloody diarrhea were reported in March 2013 and February 2014 in a breeding colony of Papillon dogs. During the first outbreak, 1 adult dog and 2 eight-month-old puppies died. During the second outbreak, 2 ten-week-old puppies died. One puppy from the first...

Author(s)
Thaiwong, T.; Wise, A. G.; Maes, R. K.; Mullaney, T.; Kiupel, M.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2016, 53, 6, pp 1204-1209
Abstract

There are dozens of recognized indigenous dog breeds in China. However, these breeds have not had extensive studies to describe their population structure, genomic linkage disequilibrium (LD) patterns, and selection signatures. Here, we systematically surveyed the genomes of 157 unrelated dogs that ...

Author(s)
Yang QianYong; Chen Hao; Ye JunHua; Liu ChenLong; Wei RongXing; Chen CongYing; Huang LuSheng
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Genetics, 2019, 10, November,
AbstractFull Text

A 10-year-old female Papillon and a 1-year-old male Golden Retriever were presented to the Tokyo University of Agriculture and Technology for a second opinion on an aortic valve stenosis (AS). The aortic flow rate was not as high as it should have been (the aortic flow velocity for case 1 and case...

Author(s)
Yoshida, T.; Matsuura, K.; Goya, S.; Ma, D.; Shimada, K.; Kitpipatkun, P.; Takeuchi, A.; Uemura, A.; Tanaka, R.
Publisher
Czech Academy of Agricultural Sciences, Prague, Czech Republic
Citation
Veterinární Medicína, 2020, 65, 2, pp 89-94
Abstract

Case report: A 7-year-old female-neutered Maltese Terrier × Papillon dog was presented with tachypnoea and weight loss following 12 months of therapy with toceranib phosphate for a metastatic, histologically-low-grade mast cell tumour. The dog was diagnosed with Pneumocystis canis based on PCR with ...

Author(s)
Best, M. P.; Boyd, S. P.; Danesi, P.
Publisher
Wiley, Melbourne, Australia
Citation
Australian Veterinary Journal, 2019, 97, 5, pp 162-165
Abstract

Case study is reported regarding a one-and-a-half year-old-year papillon (continental toy spaniel) which displays oesophageal obstruction caused by a snack food. The papillon is hospitalized after the displays of several times vomiting, followed by x-ray inspection which diagnoses it oesophageal...

Author(s)
Sato, Y.
Publisher
Buneido Publishing Company Ltd, Tokyo, Japan
Citation
Journal of Veterinary Medicine, Japan, 2014, 67, 4, pp 281-285
Abstract

A 5-year-2-month-old male Papillon presented with exercise intolerance that had begun 1 week ago. Hematological examination indicated severe non-regenerative anemia. Bone marrow aspiration smears revealed erythroid hyperplasia accompanied by apparent erythroid maturation arrest, and phagocytosis of ...

Author(s)
Hase, K.; Hase, T.
Publisher
Japanese Society of Clinical Veterinary Medicine, Tottori, Japan
Citation
Journal of Animal Clinical Medicine, 2018, 27, 4, pp 153-156
Abstract

Neuroaxonal dystrophy (NAD) was examined in two Papillon dogs and a mix breed dog between Papillon and Chihuahua. In addition, cerebellar cortical abiotrophy (CCA) in a Papillon dog, which had similar clinical and magnetic resonance imaging (MRI) features to those of NAD, was also investigated. The ...

Author(s)
Nibe, K.; Kita, C.; Morozumi, M.; Awamura, Y.; Tamura, S.; Okuno, S.; Kobayashi, T.; Uchida, K.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2007, 69, 10, pp 1047-1052

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