Cookies on VetMed Resource

Like most websites we use cookies. This is to ensure that we give you the best experience possible.

 

Continuing to use www.cabi.org  means you agree to our use of cookies. If you would like to, you can learn more about the cookies we use.

VetMed Resource

Veterinary information to support practice, based on evidence and continuing education

Sign up to receive our Veterinary & Animal Sciences e-newsletter, book alerts and offers direct to your inbox.

Results per page:

Search results

Abstract

Deletion of 4-base pairs in the canine ABCB1 (MDR1) gene, responsible for encoding P-glycoprotein, leads to nonsense frame-shift mutation, which causes hypersensitivity to macrocyclic lactones drugs (e.g. ivermectin). To date, at least 12 purebred dog breeds have been found to be affected by this...

Author(s)
Firdova, Z.; Turnova, E.; Bielikova, M.; Turna, J.; Dudas, A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2016, 106, pp 89-92
Abstract

This study was conducted to investigate the presence and prevalence of the MDR1 mutation in dog breeds in the UK. PCR for the MDR1 mutation was performed on DNA that was extracted from buccal swabs or residual blood obtained from 642 dogs belonging to 40 breeds. MDR1 mutation was found in 6 breeds, ...

Author(s)
Tappin, S. W.; Goodfellow, M. R.; Peters, I. R.; Day, M. J.; Hall, E. J.; Mealey, K. L.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2012, 171, 3, pp 72
Abstract

P-glycoprotein, encoded by the MDR1 or ABCB1 gene, is an integral component of the blood-brain barrier as an efflux pump for xenobiotics crucial in limiting drug uptake into the central nervous system. Dogs homozygous for a 4-base pair deletion of the canine MDR1 gene show altered expression or...

Author(s)
Mizukami, K.; Chang HyeSook; Yabuki, A.; Kawamichi, T.; Hossain, M. A.; Rahman, M. M.; Uddin, M. M.; Yamato, O.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2012, 24, 1, pp 127-134
Abstract

Ivermectin sensitivity in collies was first described in 1983 and since then many veterinary practitioners have been following the adage "white feet, don't treat". Ivermectin causes neurologic toxicity in a subpopulation of collies at doses 200-fold lower than those required to cause toxicity in...

Author(s)
Bourassi, E.; Berny, P.
Publisher
Veterinary Business Development Ltd, Peterborough, UK
Citation
Veterinary Times, 2015, 45, 14, pp 20-22
Abstract

A moderate number of oval-shaped, 114.7×61.3 µm in size, amber-colored, arthropod-like eggs that had chitinous, smooth, semi-thickened outer wall and 2-4 short appendages armed with 2 terminal hook-like structures were detected in multiple fecal samples from an approximately 9-month-old, intact...

Author(s)
Nagamori, Y.; Ramachandran, A.; Kuzma, C.; Nafe, L.; Johnson, E. M.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology: Regional Studies and Reports, 2019, 16, pp 100273
AbstractFull Text

Collie eye anomaly (CEA) is an inherited eye disease affecting development of the choroids and sclera segregating in several, mostly herding breeds of dog. Phenotypic development of the disease varies greatly in the affected animals. Genetic control of its clinical variation is unknown so far....

Author(s)
Dostál, J.; Horák, P.; Hrdlicová, A.; Stratil, A.
Publisher
Institute of Agricultural Economics and Information, Prague, Czech Republic
Citation
Czech Journal of Animal Science, 2010, 55, 8, pp 346-350
Abstract

In this retrospective study, the results of 3'527 eye examinations in 6 different breeds affected with Collie Eye Anomaly (CEA) over a period of 8 years (1999-2007) are described. CEA was divided into three main ophthalmoscopic features, (a) choroidal hypoplasia (CRH), (b) CRH and coloboma and (c)...

Author(s)
Waiser-Reinhardt, L.; Hässig, M.; Spiess, B.
Publisher
Verlag Hans Huber, Bern, Switzerland
Citation
SAT, Schweizer Archiv für Tierheilkunde, 2009, 151, 12, pp 597-603
Abstract

A deletion mutation in the canine multidrug resistance gene, MDR1, is associated with drug sensitivity. This was shown for several purebred dog breeds from the Collie lineage such as the Collie (rough-coated and smooth-coated), the Australian Shepherd and the Old English sheepdog. To determine...

Author(s)
Fecht, S.; Wöhlke, A.; Hamann, H.; Distl, O.
Publisher
Blackwell Publishing, Berlin, Germany
Citation
Journal of Veterinary Medicine. Series A, 2007, 54, 8, pp 401-405
Abstract

To assess the relevance of spindle cell tumours in the canine gastrointestinal (GI) tract and to classify them, a retrospective study was carried out on haematoxylin and eosin-stained sections from formalin-fixed paraffin wax-embedded samples of 105 primary GI tumours. Seventeen out of 105 (16%) GI ...

Author(s)
Bettini, G.; Morini, M.; Marcato, P. S.
Publisher
W.B. Saunders, London, UK
Citation
Journal of Comparative Pathology, 2003, 129, 4, pp 283-293
Abstract

Avermectins can provoke life-threatening neurotoxicosis in MDR1-mutant dogs due to their highly increased permeability across the blood-brain barrier in the absence of MDR1. Therapeutic options are still limited; therefore, we decided to treat this type of intoxication in two dogs using lipid...

Author(s)
Held, S.; Gramer, I.; Hassdenteufel, E.; Neiger, R.; Geyer, J.
Publisher
Verlag M. & H, Schaper Gmbh, Hannover, Germany
Citation
Kleintierpraxis, 2012, 57, 6, pp 313...319

Refine Results

Sort Order
Author
Geographical Location
Item Type
Language
Organisms
Subject Topics