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Abstract

Background: A mutation in the canine multidrug resistance MDR1 gene (also referred as ABCB1), encoding for the multidrug resistance (MDR) P-glycoprotein (P-gp) transponder, causes a pathological condition known as 'ivermectin toxicosis'. The causative mutation, known since 2001, has been described...

Author(s)
Marelli, S. P.; Polli, M.; Frattini, S.; Cortellari, M.; Rizzi, R.; Crepaldi, P.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record Open, 2020, 7, e000375,
Abstract

To clarify the prevalence of canine intracranial tumors in Japan, a retrospective study was performed using data on 186 canine intracranial tumors. Of 186 cases, 159 cases (85.5%) were primary and 27 cases (14.5%) were secondary intracranial tumors. Among primary intracranial tumors, meningioma...

Author(s)
Kishimoto, T. E.; Uchida, K.; Chambers, J. K.; Kok MunKeong; Son, N. V.; Shiga, T.; Hirabayashi, M.; Ushio, N.; Nakayama, H.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2020, 82, 1, pp 77-83
Abstract

Canine degenerative myelopathy (DM) is an adult-onset, progressive neurodegenerative disease that occurs in multiple dog breeds. A DM-associated mutation of the canine superoxide dismutase 1 (SOD1) gene, designated as c.118 G>A (p.E40K), has been implicated as one of pathogenetic determinants of...

Author(s)
Kohyama, M.; Kitagawa, M.; Kamishina, H.; Kobatake, Y.; Yabuki, A.; Sawa, M.; Kakita, S.; Yamato, O.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2017, 79, 2, pp 375-379
Abstract

Fear-related problems are common among Rough Collies in Sweden. Annually, on average, >200 Rough Collies are subjected to the dog mentality assessment (DMA), a temperament test during which 33 behavioral reactions are rated. Previous research has shown that a dog's DMA result can be condensed into...

Author(s)
Arvelius, P.; Asp, H. E.; Fikse, W. F.; Strandberg, E.; Nilsson, K.
Publisher
American Society of Animal Science, Savoy, USA
Citation
Journal of Animal Science, 2014, 92, 11, pp 4843-4855
Abstract

Background: Sensitivity to macrocyclic lactones, which are commonly used in veterinary clinics, was first found in Rough Collies, and was attributed in 2001 to a 4 bp deletion in the MDR1 gene. The list of affected breeds currently includes 13 breeds. Researchers from different countries and...

Author(s)
Dekel, Y.; Machluf, Y.; Stoler, A.; Aderet, A.; Baumel, D.; Kellerman, E.; Plotsky, Y.; Partouche, O. N.; Elhalal, G.; Ben-Shlomo, I.; Bercovich, D.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2017, 13, 333, pp (13 November 2017)
Abstract

Collie eye anomaly (CEA) is a congenital, inherited ocular disorder which is widespread in herding breeds. Clinically, the two major lesions associated with CEA are choroidal hypoplasia (CH) and coloboma, and both lesions are diagnosed based on ophthalmological examination. A 7.8-kb intronic...

Author(s)
Fredholm, M.; Larsen, R. C.; Jönsson, M.; Söderlund, M. A.; Hardon, T.; Proschowsky, H. F.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Animal Genetics, 2016, 47, 2, pp 250-252
Abstract

Deletion of 4-base pairs in the canine ABCB1 (MDR1) gene, responsible for encoding P-glycoprotein, leads to nonsense frame-shift mutation, which causes hypersensitivity to macrocyclic lactones drugs (e.g. ivermectin). To date, at least 12 purebred dog breeds have been found to be affected by this...

Author(s)
Firdova, Z.; Turnova, E.; Bielikova, M.; Turna, J.; Dudas, A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2016, 106, pp 89-92
Abstract

This study was conducted to investigate the presence and prevalence of the MDR1 mutation in dog breeds in the UK. PCR for the MDR1 mutation was performed on DNA that was extracted from buccal swabs or residual blood obtained from 642 dogs belonging to 40 breeds. MDR1 mutation was found in 6 breeds, ...

Author(s)
Tappin, S. W.; Goodfellow, M. R.; Peters, I. R.; Day, M. J.; Hall, E. J.; Mealey, K. L.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2012, 171, 3, pp 72
Abstract

P-glycoprotein, encoded by the MDR1 or ABCB1 gene, is an integral component of the blood-brain barrier as an efflux pump for xenobiotics crucial in limiting drug uptake into the central nervous system. Dogs homozygous for a 4-base pair deletion of the canine MDR1 gene show altered expression or...

Author(s)
Mizukami, K.; Chang HyeSook; Yabuki, A.; Kawamichi, T.; Hossain, M. A.; Rahman, M. M.; Uddin, M. M.; Yamato, O.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2012, 24, 1, pp 127-134
Abstract

A syndrome of ulcerative dermatitis (UDSSC) previously has been described as unique to the Shetland sheepdog and rough collie dog. The pathogenesis of this disease is poorly understood and it has been suggested that it may be a variant of canine dermatomyositis (DM) which is also seen in these...

Author(s)
Jackson, H. A.; Olivry, T.
Publisher
Blackwell Science, Oxford, UK
Citation
Veterinary Dermatology, 2001, 12, 1, pp 19-27

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