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Abstract

Primary ciliary dyskinesia (PCD) is a hereditary defect of motile cilia in humans and several domestic animal species. Typical clinical findings are chronic recurrent infections of the respiratory tract and fertility problems. We analyzed an Alaskan Malamute family, in which two out of six puppies...

Author(s)
Anderegg, L.; Gut, M. I. H.; Hetzel, U.; Howerth, E. W.; Leuthard, F.; Kyöstilä, K.; Lohi, H.; Pettitt, L.; Mellersh, C.; Minor, K. M.; Mickelson, J. R.; Batcher, K.; Bannasch, D.; Vidhya Jagannathan; Leeb, T.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS Genetics, 2019, 15, 9, pp 1008378
Abstract

The first cases of early-onset progressive polyneuropathy appeared in the Alaskan Malamute population in Norway in the late 1970s. Affected dogs were of both sexes and were ambulatory paraparetic, progressing to non-ambulatory tetraparesis. On neurologic examination, affected dogs displayed...

Author(s)
Bruun, C. S.; Jäderlund, K. H.; Berendt, M.; Jensen, K. B.; Spodsberg, E. H.; Gredal, H.; Shelton, G. D.; Mickelson, J. R.; Minor, K. M.; Lohi, H.; Bjerkås, I.; Stigen, Ø.; Espenes, A.; Rohdin, C.; Edlund, R.; Ohlsson, J.; Cizinauskas, S.; Leifsson, P. S.; Drögemüller, C.; Moe, L.; Cirera, S.; Fredholm, M.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2013, 8, 2, pp e54547
AbstractFull Text

A homozygous mutation has been identified in the N-myc downstream-regulated gene 1 (NDRG1) in recent cases of polyneuropathy in Alaskan malamute dogs from the Nordic countries and USA. The objective of the present study was to determine if cases diagnosed 30-40 years ago with polyneuropathy in the ...

Author(s)
Jäderlund, K. H.; Rohdin, C.; Berendt, M.; Stigen, Ø.; Fredholm, M.; Espenes, A.; Bjerkås, I.; Moe, L.
Publisher
BioMed Central Ltd, London, UK
Citation
Acta Veterinaria Scandinavica, 2017, 59, 26, pp (2 May 2017)
Abstract

Objective: To prove the hypothesis that a polyneuropathy in Alaskan Malamutes has a genetic background. Material and methods: Pedigrees of 131 related Alaskan Malamutes were included in the current study. Neurological examination, electrodiagnosis as well as muscle and nerve biopsies could be...

Author(s)
Rentmeister, K.; Bilzer, T.; Petri, S.; Schanen, G.; Fehr, M.; Distl, O.; Tipold, A.
Publisher
Schattauer GmbH, Stuttgart, Germany
Citation
Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, 2012, 40, 1, pp 26-34
Abstract

Background: The Alaskan sled dog offers a rare opportunity to investigate the development of a dog breed based solely on performance, rather than appearance, thus setting the breed apart from most others. Several established breeds, many of which are recognized by the American Kennel Club (AKC),...

Author(s)
Huson, H. J.; Parker, H. G.; Runstadler, J.; Ostrander, E. A.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genetics, 2010, 11, 71, pp (22 July 2010)
Abstract

Background: Achromatopsia is an autosomal recessive disease characterized by the loss of cone photoreceptor function that results in day-blindness, total colorblindness, and decreased central visual acuity. The most common causes for the disease are mutations in the CNGB3 gene, coding for the beta...

Author(s)
Yeh, C. Y.; Goldstein, O.; Kukekova, A. V.; Holley, D.; Knollinger, A. M.; Huson, H. J.; Pearce-Kelling, S. E.; Acland, G. M.; Komáromy, A. M.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Genetics, 2013, 14, 27, pp (20 April 2013)
Abstract

Throughout most of the Americas, post-colonial dogs largely erased the genetic signatures of pre-historical dogs. However, the North American Arctic harbors dogs that are potentially descended from pre-historical ancestors, as well as those affected by post-colonial translocations and admixtures....

Author(s)
Brown, S. K.; Darwent, C. M.; Wictum, E. J.; Sacks, B. N.
Publisher
Nature Publishing Group, London, UK
Citation
Heredity, 2015, 115, 6, pp 488-495
Abstract

Day blindness is a progressive and specific degeneration of cone photoreceptors in the retina of young dogs. This disorder has been associated with a breed-specific non-synonymous substitution in exon 6 of the cyclic nucleotide gated channel β3 (CNGB3) gene in German Shorthaired Pointer dogs and a...

Author(s)
Seddon, J. M.; Hampson, E. C. G. M.; Smith, R. I. E.; Hughes, I. P.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Animal Genetics, 2006, 37, 4, pp 407-410
Abstract

A 2-year old castrated male Alaskan malamute was referred with primary complaints of marked anemia, hemeglobinuria and depression. Laboratory tests revealed canine babesiois with severe anemia. The dog was treated by blood transfusion and beneril (diminazene aceturate, 3.5 mg/kg IM). Two days after ...

Author(s)
Han DongHyun; Yoon WonKyoung; Hyun ChangBaig
Publisher
Korean Society of Veterinary Science, Daejon, Korea Republic
Citation
Korean Journal of Veterinary Research, 2014, 54, 3, pp 193-196
Abstract

Alaskan sled dogs are a genetically distinct population shaped by generations of selective interbreeding with purebred dogs to create a group of high-performance athletes. As a result of selective breeding strategies, sled dogs present a unique opportunity to employ admixture-mapping techniques to...

Author(s)
Huson, H. J.; Holdt, B. M. von; Rimbault, M.; Byers, A. M.; Runstadler, J. A.; Parker, H. G.; Ostrander, E. A.
Publisher
Springer, New York, USA
Citation
Mammalian Genome, 2012, 23, 1/2, pp 178-194

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