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Abstract

BRCA1-associated protein-1 (BAP1) is a nuclear localized deubiquitylating enzyme that belongs to the ubiquitin c-terminal hydrolase subfamily. The encoded protein is highly homologous between man and dogs, suggesting a functional significance preserved by evolution. BAP1 has multiple properties,...

Author(s)
Jama, N.; Farquhar, N.; Butt, Z.; Coupland, S. E.; Sacco, J. J.; Scase, T.; Fielding, A. B.; Coulson, J. M.; Kalirai, H.; Killick, D. R.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Comparative Pathology, 2018, 162, pp 50-58
Abstract

Objective: To evaluate if 14 genes that discriminate metastasising and non-metastasising human uveal melanomas can differentiate metastasising and non-metastasising uveal melanomas in dogs. Methods: Nineteen archival biopsies of eyes with a histopathological classification of primary benign (n=9)...

Author(s)
Malho, P.; Dunn, K.; Donaldson, D.; Dubielzig, R. R.; Birand, Z.; Starkey, M.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Small Animal Practice, 2013, 54, 11, pp 584-593
Abstract

Senescent cells display an irreversible cell cycle arrest with resistance to apoptosis. They are known to accumulate with age in mice, monkeys and man, and are suspected to drive the development and progression of neoplasia. Eyes develop age-associated changes, most commonly in the retina, cornea...

Author(s)
Merz, S. E.; Kershaw, O.; Petrick, A.; Gruber, A. D.; Klopfleisch, R.; Breithaupt, A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Comparative Pathology, 2019, 173, pp 41-48
AbstractFull Text

In this report we present the clinical case of a Harlequin Great Dane male canine, which presented the opaque and very red right eye. In the ophthalmological examination he presented an acute picture of uveitis, followed by glaucoma and visual deficit, and does not report physical trauma or a blunt ...

Author(s)
Acevedo Toro, S.; Velásquez Betancur, P. A.
Publisher
Universidad CES, Facultad Veterinaria y Zootecnia, Medellín, Colombia
Citation
Revista CES Medicina Veterinaria y Zootecnia, 2019, 14, 2, pp 59-70
Abstract

Cellular senescence was discovered in cell culture by Hayflick and Moorhead in 1965 in human fibroblasts. It is primarily characterized by irreversible cell cycle arrest and an altered, enlarged morphology. Senescent cells are thought to accumulate with age in a variety of species including mice,...

Author(s)
Merz, S.
Publisher
Freien Universität Berlin, Berlin, Germany
Citation
Age- and tumor-dependent senescence in canine testis and eye, 2019, pp 56 pp.
Abstract

Melanomas have different behavior between species and is of great importance to characterize the molecular mechanism influencing this behavioral diversity. The objective of this study was to evaluate the molecular characteristics of uveal melanocytic neoplasias in dogs, in order to understand the...

Author(s)
Perlmann, E.
Publisher
Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil
Citation
Estudo imunoistoquímico das neoplasias melanocíticas uveais em cães, 2015, pp 72 pp.
Abstract

Canine malignant melanoma, a significant cause of mortality in domestic dogs, is a powerful comparative model for human melanoma, but little is known about its genetic etiology. We mapped the genomic landscape of canine melanoma through multi-platform analysis of 37 tumors (31 mucosal, 3 acral, 2...

Author(s)
Hendricks, W. P. D.; Zismann, V.; Karthigayini Sivaprakasam; Legendre, C.; Poorman, K.; Tembe, W.; Perdigones, N.; Kiefer, J.; Liang, W.; DeLuca, V.; Stark, M.; Ruhe, A.; Froman, R.; Duesbery, N. S.; Washington, M.; Aldrich, J.; Neff, M. W.; Huentelman, M. J.; Hayward, N.; Brown, K.; Thamm, D.; Post, G.; Chand Khanna; Davis, B.; Breen, M.; Sekulic, A. (et al)
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS Genetics, 2018, 14, 9, pp e1007589
Abstract

Background: Uveal melanoma (UM) is the most common primary intraocular tumour in dogs. There is no effective means of predicting whether a tumour will metastasize. microRNA (miRNA) metastasis signatures have been identified for several human cancers, including UM. Aims: In this study we...

Author(s)
Starkey, M. P.; Compston-Garnett, L.; Malho, P.; Dunn, K.; Dubielzig, R.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 1, pp 81-89
Abstract

Melanocytic neoplasms in veterinary species occur in various ophthalmic locations including the eyelid, conjunctiva, cornea, sclera, anterior and posterior uvea, and orbit. Histology usually provides the definitive diagnosis for melanocytic ocular neoplasias. The degree of tissue invasiveness and...

Author(s)
Wang, A. L.; Kern, T.
Publisher
Elsevier Inc, Orlando, USA
Citation
Topics in Companion Animal Medicine, 2015, 30, 4, pp 148-157
Abstract

Objective - To determine whether cyclooxygenase-2 (COX-2) is expressed in benign or malignant canine uveal melanocytic neoplasms and whether expression correlates with malignancy. Sample Population - Tissue sections from 71 globes; 57 with benign (n=15), malignant (34), or mixed (8) uveal...

Author(s)
Paglia, D.; Dubielzig, R. R.; Kado-Fong, H. K.; Maggs, D. J.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2009, 70, 10, pp 1284-1290

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