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Abstract

The blood brain barrier is the major obstacle to treating lysosomal storage disorders of the central nervous system such as canine fucosidosis. This barrier was overcome by three, monthly injections of recombinant canine α-L-fucosidase enzyme were given intracisternally. In dogs treated from 8...

Author(s)
Kondagari, G. S.; King, B. M.; Thomson, P. C.; Williamson, P.; Clements, P. R.; Fuller, M.; Hemsley, K. M.; Hopwood, J. J.; Taylor, R. M.
Publisher
Academic Press, London, UK
Citation
Experimental Neurology, 2011, 230, 2, pp 218-226
Abstract

Background: Low vitamin D increases the risk of immune-mediated disease (IMD) in human beings and rodent models. Vitamin D metabolites, particularly 1,25(OH)2D3, modulate gene expression of immune cells and may attenuate immune pathways that drive IMD. Hypothesis/objectives: Our primary hypothesis...

Author(s)
Mick, P. J.; Peng, S. A.; Loftus, J. P.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2019, 6, July, pp 247
Abstract

Background: Periodontal disease (PD) is a highly prevalent inflammatory disease in dogs. This disease is initiated by a polymicrobial biofilm on the teeth surface, whose control includes its prevention and removal. Recently, it was shown that nisin displays antimicrobial activity against canine...

Author(s)
Cunha, E.; Freitas, F. B.; Braz, B. S.; Silva, J. M. da; Tavares, L.; Veiga, A. S.; Oliveira, M.
Publisher
MDPI AG, Basel, Switzerland
Citation
Antibiotics, 2020, 9, 4,
Abstract

Urine biomarkers are sensitive indicators of early-stage renal injury, consequently, research in this area is expanding in both human and veterinary medicine. However, studies investigating the impact of preanalytical factors, such as storage conditions, on urine biomarker concentrations are...

Author(s)
Defauw, P.; Meyer, E.; Duchateau, L.; Schoeman, J. P.; Maele, I. van de; Daminet, S.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2017, 29, 3, pp 346-350
AbstractFull Text

Hepcidin is a peptide hormone and the main regulator of iron metabolism in the body. It was discovered in human serum and urine in 2000 and named liver expressed antimicrobial protein-1 (LEAP-1). Research of antimicrobial peptides in relation to inflammatory response was conducted by Tomas Ganz. He ...

Author(s)
Artuković Nadinić, I.; Barić Rafaj, R.; Bedrica, L.; Pavlak, M.; Lipar, M.; Mrljak, V.
Publisher
Hrvatski veterinarski institut, Centar za peradarstvo, Zagreb, Croatia
Citation
Veterinarska Stanica, 2020, 51, 2, pp 187-198
Abstract

Thrombocytopenia is commonly encountered in veterinary practice when evaluating canine patients. It can occur in infectious, neoplastic, inflammatory, toxic, and immune-mediated conditions. Elucidating the underlying cause for thrombocytopenia can therefore represent a challenge to veterinary...

Author(s)
Shropshire, S.; Dow, S.; Lappin, M.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2018, 202, pp 109-114
Abstract

Background: DNA is released from dying cells during apoptosis and necrosis. This cell-free DNA (cfDNA) diffuses into the plasma where it can be measured. In humans, an increase in cfDNA correlates with disease severity and prognosis. Objective: It was hypothesized that when DNA in canine plasma was ...

Author(s)
Burnett, D. L.; Cave, N. J.; Gedye, K. R.; Bridges, J. P.
Publisher
Taylor & Francis, Abingdon, UK
Citation
Veterinary Quarterly, 2016, 36, 3, pp 122-129
Abstract

OBJECTIVE: To evaluate stability of coagulation factors in canine plasma obtained by use of plasmapheresis and stored over a 36-month period. SAMPLE: Canine plasma obtained by use of plasmapheresis acquired from a commercial blood bank. PROCEDURES: Coagulation testing for fibrinogen concentration...

Author(s)
Donahue, M. E.; Fernandez, A. L.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2019, 80, 6, pp 578-585
Abstract

Atopic dermatitis is a very common condition affecting dogs and often managed with allergen-specific immunotherapy, which requires accurate identification of causative allergens. Serology testing is used commonly. Serum was collected from 35 atopic dogs and separated into three samples each (1, 2,...

Author(s)
Zhou ZiJin; Pieper, J. B.; Campbell, K.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2019, 55, 3, pp 124-129
Abstract

Studies involving gut microbiome analysis play an increasing role in the evaluation of health and disease in humans and animals alike. Fecal sampling methods for DNA preservation in laboratory, clinical, and field settings can greatly influence inferences of microbial composition and diversity, but ...

Author(s)
Horng, K. R.; Ganz, H. H.; Eisen, J. A.; Marks, S. L.
Publisher
PeerJ, San Francisco, USA
Citation
PeerJ, 2018, 6, 4827, pp e4827

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