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Abstract

Objective: To report recovery of ambulation of dogs treated with extended thoracolumbar durotomy for severe spinal cord injury caused by intervertebral disc herniation. Study design: Descriptive cohort. Animals: Twenty-six consecutive paraplegic dogs presented with loss of deep pain sensation after ...

Author(s)
Jeffery, N. D.; Mankin, J. M.; Ito, D.; Boudreau, C. E.; Kerwin, S. C.; Levine, J. M.; Krasnow, M. S.; Andruzzi, M. N.; Alcott, C. J.; Granger, N.
Publisher
Wiley, Boston, USA
Citation
Veterinary Surgery, 2020, 49, 5, pp 884-893
Abstract

Background. Glyburide (also known as glibenclamide) is effective in reducing the severity of tissue destruction and improving functional outcome after experimental spinal cord injury in rodents and so has promise as a therapy in humans. There are many important differences between spinal cord ...

Author(s)
Jeffery, N.; Boudreau, C. E.; Konarik, M.; Mays, T.; Fajt, V.
Publisher
PeerJ, San Francisco, USA
Citation
PeerJ, 2018, 6, 4387, pp e4387
Abstract

Spinal cord injury may cause a range of symptoms from neck or back pain to complete paralysis and loss of autonomic function i.e., bowel and bladder control. The present study included a total of 45 clinical cases of spinal cord injury brought to the Referral Veterinary Polyclinic IVRI Izatnagar...

Author(s)
Singh, A. P.; Amarpal; Kinjavdekar, P.; Pawde, A. M.; Aithal, H. P.; Raghuvanshi, P. D. S.; Gautam, D.
Publisher
Indian Society for Veterinary Surgery, Hisar, India
Citation
Indian Journal of Veterinary Surgery, 2018, 39, 2, pp 100-104
Abstract

Some dogs that become paraplegic after severe spinal cord injury regain ambulation on the pelvic limbs despite permanent loss of pelvic limb sensation, a phenomenon termed 'spinal walking'. Plastic changes in spinal cord circuitry are thought to mediate this form of recovery but the precise...

Author(s)
Hu, H. Z.; Jeffery, N. D.; Granger, N.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2018, 237, pp 49-54
Abstract

Severe spinal cord injury (SCI) causing significant morbidity and mortality remains one of the most challenging problems in both human and veterinary medicine. Due to the restricted regeneration potential of the central nervous system (CNS) in mammals, the neurological deficit caused by spinal cord ...

Author(s)
Šulla, I.; Horňák, S.; Ledecký, V.; Balik, V.
Publisher
University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
Citation
Acta Veterinaria Brno, 2019, 88, 2, pp 207-217
Abstract

Olfactory ensheathing cells are thought to support regeneration and remyelination of damaged axons when transplanted into spinal cord injuries. Following transplantation, improved locomotion has been detected in many laboratory models and in dogs with naturally-occurring spinal cord injury; safety...

Author(s)
Ito, D.; Carwardine, D.; Prager, J.; Wong LiangFong; Kitagawa, M.; Jeffery, N.; Granger, N.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 3, pp e0213252
Abstract

Spinal cord injury (SCI) is a serious condition that causes profound economic and emotional impact in human patients and companion animal owners. It has been shown that the neurogenic effects of the stem cells are enhanced when combined with electroacupuncture (EA) in rodent models of SCI. To...

Author(s)
Prado, C.; Fratini, P.; Matias, G. de S. S.; Bocabello, R. Z.; Monteiro, J.; Santos, C. J. dos; Joaquim, J. G. F.; Giglio, R. F.; Possebon, F. S.; Sakata, S. H.; Miglino, M. A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2019, 123, pp 247-251
Abstract

Spinal cord injuries (SCI) in dogs are not frequent, but they are serious pathological conditions accompanied with high morbidity and mortality. The pathophysiology of SCI involves a primary insult, disrupting axons, blood vessels, and cell membranes by mechanical force, or causes tissue necrosis...

Author(s)
Šulla, I.; Balik, V.; Horňák, S.; Ledecký, V.
Publisher
Sciendo, Warsaw, Poland
Citation
Folia Veterinaria, 2018, 62, 2, pp 35-44
Abstract

The spinal cord ependymal layer (SEL) is a recent focus in spinal cord injury (SCI) research because of its potential to serve as a source of endogenous neural stem cells. Dogs are an important spontaneous model of SCI; however, there is a paucity of information available in the literature...

Author(s)
Moore, S. A.; Oglesbee, M. J.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2015, 52, 6, pp 1108-1117
Abstract

The regeneration of damaged nerve cells of the central nervous system (CNS) is limited due to factors intrinsic to the own cell niche. The glial scar, the release of axonal growth inhibitors, and the phagocytic action of astrocytes are factors that limit this regeneration, deterring axonal...

Author(s)
Feitosa, M. L. T.
Publisher
Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil
Citation
Terapia celular com células-tronco cm coelhos com lesão medular induzida e em cães com lesão medular crônica espontânea, 2011, pp 131 pp.

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