Heat shock proteins (HSPs) are strongly implicated in the control of cell growth, differentiation and biological behaviour of many human cutaneous neoplasms. To our knowledge, no data have been published in the veterinary literature concerning either normal or neoplastic skin. In this study, the...

Skin tumours (n=148) of epidermal or hair follicle origin were examined immunohistochemically to determine the expression of p27^Kip1 (p27), a cyclin-dependent kinase inhibitor (CDKI), and of Ki-67. In normal skin, a large number of basal cells of the epidermis and hair follicles were positive for...

Neoplasms derived from the hair follicle are benign skin tumours often seen in dogs and very rarely in cats. These tumours are classified as trichoepithelioma, pilomatrixoma and karatoacanthoma or intracutaneous cornifying epithelioma (ICE). Canine ICE may develop as a solitary lesion consisting...

As intracutaneous cornifying epitheliomas and squamous cell carcinomas are similar in many respects, various methods for diagnosing these were compared: immunostaining for proliferating cell nuclear antigen (PCNA) clone PC10, interphase nucleolar organizer regions staining (AgNORs), and the mitotic ...

A case of multiple intracutaneous cornifying epitheliomata in a Kerry blue terrier is reported. The lesions were multifocal and characterised by well circumscribed dermal tumours varying from 0.3 to 6.0 cm in diameter with a pore opening on to the skin surface. The successful control with...

A typical intracutaneous cornifying epithelioma consisted of a keratin-filled crypt in the dermis and subcutis that opened to the skin surface. Most of these tumours occurred on the back, neck, sides of the thorax, and the shoulders. Two distinct patterns existed-a solitary form (single growth) and ...

Inverted papillomas of the skin in 5 dogs were 1-2 cm, circumscribed, flask-like structures below the level of the surrounding normal skin. Walls of the structures consisted of hyperplastic epidermis, forming thin papillary projections on thin fibrovascular stalks. Cells in the stratum granulosum...

The intracutaneous cornifying epithelioma of dogs was compared with keratoacanthoma of man based on findings in the literature and in laboratory studies. The two tumours differ at the following points: epithelium of origin, rate of growth, infiltration, spontaneous involution, breed predisposition...

The synthetic retinoids isotretinoin and etretinate were evaluated as treatments for dogs with intracutaneous cornifying epitheliomas (ICE), other benign skin neoplasias, and cutaneous lymphoma. Ten dogs with multiple (at least 5) benign skin tumours (7 with ICE, 1 each with inverted papillomas,...

Apoptotic cell death was investigated in routinely processed tissue samples of 39 neoplasms of the skin and subcutaneous tissues of dogs using terminal deoxynucleotidyl transferase (Td) mediated deoxyuridine-5′-triphosphate (dUTP)-biotin nick end labelling (TUNEL). The degree of apoptosis was...