Symptoms and diagnosis of non-inflammatory alopecia (hair loss) dominated by endocrine system dysfunctions are considered. Information is presented on alopecia X syndrome or pattern baldness. Cases of alopecia X are grouped into alopecias responsive to testosterone, oestrogens, castration, growth...

Pituitary function and short-term clinical effects after transsphenoidal hypophysectomy were investigated in clinically normal dogs. In study I, 8 dogs were given polyionic fluids i/v during the first 12 h after surgery. In study II, 4 dogs were given polyionic fluids i/v and glucocorticoid...

Excessive trichilemmal keratinization (flame follicle formation) was observed in the skin biopsies from 61 of 403 (15.1%) dogs with endocrine skin disease. Flame follicles occurred in dogs with hypothyroidism, hyperadrenocorticism, hyposomatotropism, Sertoli's cell neoplasm with feminisation and...

An acquired defect in growth hormone secretion in mature dogs has been associated with some forms of generalised alopecia. To elucidate the pathogenesis of the disturbance in growth hormone release, the plasma concentrations of growth hormone and insulin-like growth factor I (IGF-I) were measured...

Adult-onset hyposomatotropism (growth hormone responsive dermatosis or pseudo-Cushing's syndrome) was diagnosed in 22 dogs. Male Pomeranians, Chow Chows, and Keeshonds were found to be predisposed. The dermatosis was characterized by symmetrical trunkal alopecia, with or without hyperpigmentation,...

Skin biopsies from 222 dogs with endocrine dermatoses were studied. These dogs accounted for 15.6% of the canine skin biopsies performed during the study. Nonspecific dermatohistopathologic findings associated with most endocrine dermatoses included hyperkeratosis, follicular keratosis, follicular...

Endocrine diseases discussed in this review include hypothyroidism, diagnosis and treatment of hypothyroidism, hyperadrenocorticism, growth hormone-responsive dermatosis (hyposomatotropism), acromegaly, hyperoestrogenism in the female dog, oestrogen-responsive dermatosis of the female dog, Sertoli...

Dynamic adrenocortical and thyroid function tests were performed on normal-coated Pomeranians (n=12) and Pomeranians with growth hormone (GH)-responsive dermatosis (n=7). Both groups of Pomeranians had decreased GH responsiveness to xylazine and human GH-releasing factor, compared with values in...

Generalized alopecia in a young adult poodle, without concurrent general signs, is indicative of a growth hormone deficiency. A case report and a review of the literature are presented.