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Abstract

Purpose: To evaluate the protein expression of somatostatin receptor (SSTR) 2, SSTR5 and dopamine D2 receptor (DA2R) - targets of somatostatin analogs and dopamine agonists - in normal canine pituitary and canine adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Methods: Six normal ...

Author(s)
Sato, A.; Hara, Y.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2018, 119, pp 61-66
Abstract

Hypophysectomy specimens from 16 dogs with pituitary adenoma were evaluated with periodic acid-Schiff (PAS), reticulin, and immunohistochemistry for adrenocorticotrophic hormone (ACTH), melanocyte stimulating hormone (MSH), growth hormone (GH), and Ki-67. The reticulin network was obliterated in...

Author(s)
Miller, M. A.; Owen, T. J.; Bruyette, D. S.; Scott-Moncrieff, J. C.; Ramos-Vara, J. A.; Weng HsinYi; Chen, A. V.; Martin, L. G.; DuSold, D. M.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2018, 55, 6, pp 889-895
Abstract

Pituitary-dependent hyperadrenocorticism (PDH) caused by pituitary corticotroph adenoma is a common endocrine disorder in dogs. The ratio between pituitary height and the area of the brain (P/B) has been used to evaluate the pituitary size. A P/B ratio >0.31 indicates an enlarged pituitary, whereas ...

Author(s)
Ishino, H.; Hara, Y.; Takekoshi, S.; Teshima, T.; Teramoto, A.; Osamura, R. Y.; Tagawa, M.
Publisher
Elsevier Inc., Philadelphia, USA
Citation
Domestic Animal Endocrinology, 2011, 41, 4, pp 207-213
Abstract

The purpose of this study was to investigate the expression of bone morphogenetic protein 4 (BMP4) and its receptors, bone morphogenetic protein receptor I (BMPRI) and BMPRII, in the pituitary gland of healthy adult dogs and in those with ACTH-secreting pituitary adenoma. Quantitative polymerase...

Author(s)
Sato, A.; Ochi, H.; Harada, Y.; Yogo, T.; Kanno, N.; Hara, Y.
Publisher
Elsevier Inc, New York, USA
Citation
Domestic Animal Endocrinology, 2017, 58, pp 126-133
Abstract

Pituitary-dependent hypercortisolism (PDH) is a common endocrinopathy in dogs, but the promotors and initiators of the tumourigenesis of corticotroph pituitary adenomas remain unknown. Based on human data, we investigated mRNA expression of pituitary tumour transforming gene 1 (PTTG1) with...

Author(s)
Vastenhout, N.; Rijn, S. J. van; Riemers, F. M.; Tryfonidou, M. A.; Meij, B. P.; Penning, L. C.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2018, 240, pp 19-21
Abstract

Cushing's disease (CD) or pituitary-dependent hypercortisolism is a common endocrinopathy in dogs, with an estimated prevalence of 1 or 2 in 1000 dogs per year. It is caused by an adrenocorticotropic hormone secreting adenoma in the pars distalis or pars intermedia of the pituitary gland. The ...

Author(s)
Rijn, S. J. van; Tryfonidou, M. A.; Hanson, J. M.; Penning, L. C.; Meij, B. P.
Publisher
Taylor & Francis, Abingdon, UK
Citation
Veterinary Quarterly, 2013, 33, 4, pp 217-224
Abstract

To optimize the histologic evaluation of hypophysectomy specimens, sections of 207 canine pituitary glands (196 postmortem, 11 hypophysectomy specimens) were reviewed. Adenohypophyseal proliferation was the most common (n=79) lesion. Proliferative lesions were sparsely to densely granulated; the...

Author(s)
Miller, M. A.; Bruyette, D. S.; Scott-Moncrieff, J. C.; Owen, T. J.; Ramos-Vara, J. A.; Weng HsinYi; Vanderpool, A. L.; Chen, A. V.; Martin, L. G.; DuSold, D. M.; Jahan, S.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2018, 55, 6, pp 871-879
Abstract

Pituitary-dependent hypercortisolism is a common endocrinopathy in dogs, caused by an adrenocorticotrophic hormone secreting pituitary tumour of the anterior or intermediate lobe. The prognosis of intermediate lobe adenomas is worse than that of anterior lobe adenomas, indicating the possible...

Author(s)
Rijn, S. J. van; Pouwer, M. G.; Tryfonidou, M. A.; Grinwis, G. C. M.; Bend, J. E. E. van der; Beukers, P. E. P. F.; Vastenhout, N.; Drouin, J.; Penning, L. C.; Meij, B. P.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2015, 204, 3, pp 315-321
Abstract

With the exception of classic functional adenomas in dogs and horses, pituitary lesions are infrequently described in the veterinary literature. Approximately 10% of pituitary glands from asymptomatic humans contain abnormalities, but the equivalent proportion in small animals is unknown. Pituitary ...

Author(s)
Polledo, L.; Grinwis, G. C. M.; Graham, P.; Dunning, M.; Baiker, K.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2018, 55, 6, pp 880-888
Abstract

Pituitary-dependent hyperadrenocorticism (PDH) in dogs is caused by a pituitary corticotroph adenoma. Although PDH is a common disorder in dogs, little is known about the underlying pathogenesis. In the pituitary glands of humans and mice, the pro-opiomelanocortin (POMC)-expressing cell lineages,...

Author(s)
Hanson, J. M.; Mol, J. A.; Leegwater, P. A. J.; Bilodeau, S.; Drouin, J.; Meij, B. P.
Publisher
Elsevier, New York, USA
Citation
Domestic Animal Endocrinology, 2008, 34, 3, pp 217-222

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