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Abstract

Regulatory T cells (Tregs) can be targeted in cancer immunotherapy. A previous study has shown that the chemokine CCL17 and the receptor CCR4 play a role in Treg recruitment in canine urothelial carcinoma. Here, we describe the association of tumor-infiltrating Tregs with CCL17/CCR4 expression in ...

Author(s)
Maeda, S.; Nakazawa, M.; Uchida, M.; Yoshitake, R.; Nakagawa, T.; Nishimura, R.; Miyamoto, R.; Bonkobara, M.; Yonezawa, T.; Momoi, Y.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2020, 57, 4, pp 497-506
Abstract

SLUG, encoded by the Snai2 gene, is known to play a role in epithelial-mesenchymal transition (EMT), which contributes to cell invasion and metastasis in some types of human carcinomas. However, the mechanisms and roles of EMT in canine squamous cell carcinoma (SCC) have not yet been elucidated. We ...

Author(s)
Noguchi, S.; Hirano, K.; Tanimoto, N.; Shimada, T.; Akiyoshi, H.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2021, 20, 1, pp 134-141
Abstract

Many types of tumorous and tumour-like lesions occur in the oral cavity of dogs. Even benign neoplasia often represents great inconvenience due to potential restrictions of therapeutic surgical approach in this area. Whereas in human medicine, there are statistical data describing areas of the oral ...

Author(s)
Putnová, B.; Burová, J.; Georgiou, M.; Fichtel, T.; Stehlík, L.; Frgelecová, L.; Škorič, M.
Publisher
University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
Citation
Acta Veterinaria Brno, 2020, 89, 2, pp 179-187
AbstractFull Text

Canine oral papilloma is a benign tumor of young dogs and caused by papillomavirus. The possible role of papillomavirus infection in the development of oral squamous cell carcinoma has recently been studied, but it has not been elucidated in veterinary medicine yet. A one-year-old, mixed, spayed,...

Author(s)
Gürgen, H. Ö.; Egeden, E.; Şennazli, G.
Publisher
Ankara Üniversitesi, Veteriner Fakültesi Dekanlig, Ankara, Turkey
Citation
Ankara Üniversitesi Veteriner Fakültesi Dergisi, 2020, 68, 1, pp 77-81
Abstract

A 7-month-old castrated French bulldog was presented with a left-sided mandibular tumor. The initial tumor biopsy diagnosis was ameloblastoma. The owner brought this dog the Kitasato University Veterinary Teaching Hospital for more detailed examination and treatment. Computed tomography revealed a...

Author(s)
Furuta, K.; Nishi, K.; Park ChunHo; Maeda, K.; Iwai, S.; Sakonjyu, I.; Saigami, K.; Okano, S.
Publisher
Canadian Veterinary Medical Association, Ottawa, Canada
Citation
Canadian Veterinary Journal, 2021, 62, 11, pp 1181-1184
Abstract

Scarce information exists on the role of mTOR pathway proteins and their association to aggressiveness and prognosis of patients with canine oral cancers. We aimed to investigate the activated form of mTOR and its downstream S6 protein in canine oral squamous cell carcinoma (OSCC), and to evaluate...

Author(s)
Delgado, L.; Brilhante-Simões, P.; Garcez, F.; Monteiro, L.; Pires, I.; Prada, J.
Publisher
MDPI AG, Basel, Switzerland
Citation
Biomolecules, 2022, 12, 7,
Abstract

The Wnt signaling pathway is well known to be involved in many types of human cancer; however, in veterinary medicine, the investigation of individual Wnt members' expression, and their role in or association with oral tumor pathogenesis, is still underevaluated. We aim to determine the expression...

Author(s)
Putnová, B.; Putnová, I.; Škorič, M.; Buchtová, M.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2021, 11, 6,
Abstract

Cyclooxygenase (COX) isoforms-1 and -2 have been extensively investigated in cancer. Although COX-2 is the isoform most studied and has been described in several malignancies associated with histologic criteria of malignancy and worse prognosis, COX-1 has also been linked to some forms of cancer....

Author(s)
Gregório, H.; Magalhães, T. R.; Pires, I.; Prada, J.; Carvalho, M. I.; Queiroga, F. L.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Medicine and Science, 2021, 7, 4, pp 1107-1119
Abstract

Canine oral papillary squamous cell carcinoma (COPSCC) is a rare neoplasm and although locally invasive it carries a favourable prognosis following wide surgical excision. Radiotherapy has been reported to be effective as an adjunct treatment to surgery. However, limited information is available on ...

Author(s)
Steen, F. van der; Zandvliet, M.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2020, 19, 1, pp 152-159
AbstractFull Text

This case report describes the outcome of treatment of dogs with advanced (deeply invasive) nasal planum squamous cell carcinomas with palliative or definitive radiation therapy. All dogs were diagnosed with nasal planum squamous cell carcinoma by histopathology, and their owners declined...

Author(s)
Cunha, S. C. S.; André, M. M.; Corgozinho, K. B.; Silva, K. V. G. C.; Silva, C. A.; Ferreira, A. M. R.
Publisher
FEPMVZ - Editora, Belo Horizonte, Brazil
Citation
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2020, 72, 1, pp 119-124

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