Dilated cardiomyopathy (DCM) is a frequent cause of cardiac disability, congestive heart failure (CHF), and arrhythmic death in dogs. The etiology of DCM is usually idiopathic/genetic, but some causes of a DCM phenotype are reversible. The disease is classified into preclinical (occult) and...

Background: Dilated cardiomyopathy (DCM) is the most common cardiac disease in large breed dogs. The disease can start with arrhythmias or with systolic dysfunction of the myocardium. Objective: To describe screening methods for DCM in various breeds and provide a new, modified staging system....

Dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in various dog breeds. The diagnosis of overt DCM is not normally problematic, although the importance of active exclusion of other causes of the dilated, hypokinetic heart is emphasized. Recent interest in human familial DCM...

Background: Dilated cardiomyopathy (DCM) results in progressive myocardial and circulatory dysfunction causing activation of a number of neurohormonal systems, including the endothelin (ET) system, which is only beginning to be described in clinical veterinary medicine. Measurement of these...

Resting heart rate variability (HRV) was evaluated as a simple noninvasive screening test for early autonomic derangement, signalling the development of occult dilated cardiomyopathy (DCM). Time and frequency domain HRV parameters were evaluated in 32 healthy Doberman pinschers, as potential...

Background: Angiotensin converting enzyme inhibitors (ACEIs) are recommended in people to treat asymptomatic (occult) dilated cardiomyopathy (DCM). Efficacy of therapy in occult DCM in dogs is unknown. Hypothesis: ACEIs, specifically benazepril hydrochloride (BH), will delay the onset of overt DCM...

In this study, radiographic, electrocardiographic and echocardiographic features of Labrador retrievers having occult dilated cardiomyopathy (DCM) were compared with normal Labrador retrievers. Sixteen clinically healthy Labrador retrievers (aged 4.69±1.82 yr, weighing 27.81±5.28 kg) without...

Objective: To evaluate retrograde coronary venous stem-cell delivery for Dobermanns with dilated cardiomyopathy. Methods: Retrograde coronary venous delivery of adipose-derived mesenchymal stem cells transduced with tyrosine mutant adeno-associated virus 2 to express stromal-derived factor-1 was...

Objective - To evaluate the use of measuring plasma concentrations of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and cardiac troponin-I (cTnI) to detect dogs with occult dilated cardiomyopathy (DCM). Animals - 118 client-owned dogs. Procedures - Dogs were prospectively...

Background: Assessment of diastolic function in patients with dilated cardiomyopathy (DCM) has the potential to add valuable information regarding hemodynamics, disease severity, and prognosis. The purpose of this study was to determine transmittal flow (TMF), isovolumic relaxation time (IVRT),...