Objective: To report a case series of canine naproxen overdoses successfully treated with intravenous lipid emulsion therapy (IVLE). Series Summary Three dogs were presented for acute ingestion of naproxen and were treated with IVLE. Baseline and post treatment serum naproxen concentrations were...

The kidney has an essential role in maintaining normal physiological functions but it can be affected by various drugs and chemicals. A common seasonal cause of renal failure in cats is ingestion of antifreeze containing ethylene glycol. It is not the ethylene glycol itself which causes renal...

This article discusses the pharmacokinetics, mechanism of action, toxicity, clinical aspects, adverse effects, decontamination, monitoring and treatment, and prognosis in dogs affected with naproxen, a non-steroidal antiinflammatory agent, toxicosis.

Naproxen, a nonsteroidal anti-inflammatory drug, induced gastric ulceration and bleeding in a dog. Clinical signs included vomiting, anaemia, melena, and weakness. The dog responded to a blood transfusion and supportive treatment (lactated Ringer's solution with added K⁺ and B vitamins, an antacid, ...

Toxicosis is described in a puppy that had been given 220 mg of naproxen (Alleve) over a 4-day period. Clinical signs included melaena, lethargy and vomiting. Treatment included blood transfusion (to treat anaemia), administration of gastroprotective medications and supportive care.

The unsuitability for dogs of this drug, prepared for human use, is shown by reference to 3 case reports. The animals showed clinical signs including vomiting, diarrhoea, anaemia, oedema, an increased tendency to bleed, fatigue, incoordination and staggering. Liver enzyme levels were raised and...

Two arthritic dogs, both old, developed high gastrointestinal tract haemorrhage after being treated by their owners with naproxen, a new drug introduced for human arthritis. Euthanasia was carried out on one. The doses were considerably higher than those recommended for the human patient.