Hydroxyurea is a chemotherapeutic agent used to treat hypereosinophilic syndrome, mast cell tumours and many myeloproliferative disorders. It is usually well tolerated; however, reported side effects include myelosuppression and gastrointestinal complications as well as cutaneous toxicity, in very...

Tumors of the hemolymphatic system derived from bone marrow cells (leukemias), especially myeloproliferative disorders are seldom described in domestic animals. However, they should be considered in differential diagnosis in cases when nonspecific clinical signs especially fever of unknown cause,...

Myeloid neoplasms include cancers associated with both rapid (acute myeloid leukemias) and gradual (myelodysplastic syndromes and myeloproliferative neoplasms) disease progression. Percentage of blast cells in marrow is used to separate acute (rapid) from chronic (gradual) and is the most...

Subjects of the contributions are: Classification of haematopoietic system neoplasia; canine lymphoma; lymphoid leukaemia; immunoglobulin-producing tumours; thymoma; myeloproliferative disorders; mast cell tumours; paraneoplastic disorders; immunomodulation; surgery; radiation and/or hyperthermia...

These course proceedings contain 12 papers by 5 experts in this field. The main speaker was Professor N. Gorman of the University of Glasgow, UK. Topics covered were: clinical approach to neoplasia; principles of therapy; radiotherapy; clinical management of skin tumours; canine mammary cancer;...

The clinical signs and pathological findings in a 2-year-old German Shepherd that was killed because of a poor prognosis, after being diagnosed as having systemic mastocytosis and myeloid proliferation, are described. In peripheral blood and in fine-needle aspirates of bone marrow, spleen and lymph ...

This is a practical guide to the correct use of 31 cytotoxic drugs for treating neoplasms in dogs and cats. The principles of tumour biology and anticancer therapy are described, as well as the chemotherapeutic agents, practical considerations (complications, safe handling of the drugs), specific...

Data on cancer cases in cats and dogs were collected systematically by the Animal Neoplasm Registry of Alameda and Contra Costa Counties, California, a population-based animal tumour registry. Aetiological relationships were examined on the basis of comparisons of age-specific, sex-specific, and...

Beagles continuously exposed to radiostrontium developed a myeloproliferative syndrome, which included two cases of myelomonocytic leucaemia. Bone marrow cells from one of the two cases were transplanted into the peritoneum, and four subsequent serial transplants were accomplished by using tumour...