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Abstract

Objective: Gross, histopathological, and immunohistochemical characteristics of uveal melanocytic neoplasms in dogs and cats were investigated. Samples Thirty-two enucleated globes with uveal melanocytic neoplasms, 27 from dogs and 5 from cats, were examined. Procedures Morphological...

Author(s)
Moreira, M. V. L.; Langohr, I. M.; Araújo Campos, M. R. de; Ferreira, E.; Carvalho, B.; Blume, G. R.; Montiani-Ferreira, F.; Ecco, R.
Publisher
Wiley, Oxford, UK
Citation
Veterinary Medicine and Science, 2022, 8, 3, pp 1036-1048
AbstractFull Text

Background: Melanoma is the most frequent cancer in the canine oral cavity. It shows an aggressive behavior, characterized by rapid and invasive growth and high metastatic potential. Metastasis is seen in more than 80% of dogs at time of death. Adjuvant therapy should be recommended because of...

Author(s)
Lavalle, G. E.; Caires, C. E. T.; Teixeira, S. V.; Castro Cunha, R. M. de; Carneiro, R. A.
Publisher
Universidade Federal do Rio Grande do Sul, Faculdade de Veterinária, Porto Alegre, Brazil
Citation
Acta Scientiae Veterinariae, 2021, 49, 1808,
Abstract

Metastatic melanoma is a very aggressive form of cancer in both humans and dogs. Dogs primarily develop oral melanoma of mucosal origin. Although oral melanoma in humans is rare, both diseases are highly aggressive with frequent metastases. This disease represents a "One Health" opportunity to...

Author(s)
Silveira, T. L.; Pang, L. Y.; Domenico, A. di; Veloso, E. S.; Silva, I. L. D.; Puerto, H. L. del; Ferreria, E.; Argyle, D. J.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2021, 7, August,
Abstract

Canine malignant melanoma is a common cancer with a high mortality rate. Although previous studies have evaluated various aspects of this tumour, the exact mechanism of tumourigenesis remains unknown. Epigenetic mechanisms, such as DNA methylation, have recently gained attention as aetiological...

Author(s)
Ishizaki, T.; Yamazaki, J.; Jelinek, J.; Aoshima, K.; Kimura, T.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2020, 132, pp 521-526
AbstractFull Text

Canine digital melanoma, in contrast to canine oral melanoma, is still largely unexplored at the molecular genetic level. The aim of this study was to detect mutant genes in digital melanoma. Paraffin-embedded samples from 86 canine digital melanomas were examined for the BRAF V595E variant by...

Author(s)
Conrad, D.; Kehl, A.; Beitzinger, C.; Metzler, T.; Steiger, K.; Pfarr, N.; Fischer, K.; Klopfleisch, R.; Aupperle-Lellbach, H.
Publisher
MDPI AG, Basel, Switzerland
Citation
Veterinary Sciences, 2022, 9, 2,
Abstract

Canine melanoma is a frequently-occuring neoplasm in dogs and presents as malignant and highly metastatic in this context, studies that contribute to the understanding of the tumor microenvironment in melanoma include the role of galectins. Galectins are proteins of the family of animal lectins...

Author(s)
Garcia, J. S.; Hazarbassanov, N. G. T. Q.; Nakamura, J. C.; Nowosh, V.; Cogliati, B.; Sá, L. R. M. de; Massoco, C. O.
Publisher
Colégio Brasileiro de Patologia Animal, Rio de Janeiro, Brazil
Citation
Pesquisa Veterinária Brasileira, 2020, 40, 12, pp 1010-1017
Abstract

Background: Canine malignant melanoma is highly aggressive and generally chemoresistant. Toceranib is a kinase inhibitor drug that inhibits several tyrosine kinases including the proto-oncogene receptor tyrosine kinase KIT. Although canine malignant melanoma cells often express KIT, a therapeutic...

Author(s)
Tani, H.; Miyamoto, R.; Noguchi, S.; Kurita, S.; Nagashima, T.; Michishita, M.; Yayoshi, N.; Tamura, K.; Bonkobara, M.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2021, 17, 147, pp (07 April 2021)
Abstract

In veterinary oncology, canine melanoma is still a fatal disease for which innovative and long-lasting curative treatments are urgently required. Considering the similarities between canine and human melanoma and the clinical revolution that immunotherapy has instigated in the treatment of human ...

Author(s)
Tarone, L.; Giacobino, D.; Camerino, M.; Ferrone, S.; Buracco, P.; Cavallo, F.; Riccardo, F.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2022, 8, February,
Abstract

Background: Malignant melanoma in dogs is considered to be largely resistant to conventional chemotherapy, although responses to carboplatin have been documented. Invasion and early metastasis are common features of certain melanoma subtypes that contribute to tumour progression despite aggressive...

Author(s)
Bernard, S.; Poon, A. C.; Tam, P. M.; Mutsaers, A. J.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2021, 17, 382, pp (11 December 2021)
Abstract

Cancer cells can evade host immune systems via multiple mechanisms. Transforming growth factor beta 1 (TGF-β1) is an immunosuppressive cytokine that induces regulatory T cell (Tregs) differentiation and is involved in immune evasion mechanisms in cancer. The inhibition of the TGF-β1 signaling...

Author(s)
Takeuchi, H.; Konnai, S.; Maekawa, N.; Takagi, S.; Ohta, H.; Sasaki, N.; Kim, S.; Okagawa, T.; Suzuki, Y.; Murata, S.; Ohashi, K.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2021, 7, June,

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