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AbstractFull Text

Background: Melanoma is the most frequent cancer in the canine oral cavity. It shows an aggressive behavior, characterized by rapid and invasive growth and high metastatic potential. Metastasis is seen in more than 80% of dogs at time of death. Adjuvant therapy should be recommended because of...

Author(s)
Lavalle, G. E.; Caires, C. E. T.; Teixeira, S. V.; Castro Cunha, R. M. de; Carneiro, R. A.
Publisher
Universidade Federal do Rio Grande do Sul, Faculdade de Veterinária, Porto Alegre, Brazil
Citation
Acta Scientiae Veterinariae, 2021, 49, 1808,
Abstract

Background: Canine malignant melanoma is highly aggressive and generally chemoresistant. Toceranib is a kinase inhibitor drug that inhibits several tyrosine kinases including the proto-oncogene receptor tyrosine kinase KIT. Although canine malignant melanoma cells often express KIT, a therapeutic...

Author(s)
Tani, H.; Miyamoto, R.; Noguchi, S.; Kurita, S.; Nagashima, T.; Michishita, M.; Yayoshi, N.; Tamura, K.; Bonkobara, M.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2021, 17, 147, pp (07 April 2021)
Abstract

Canine malignant melanoma is a common cancer with a high mortality rate. Although previous studies have evaluated various aspects of this tumour, the exact mechanism of tumourigenesis remains unknown. Epigenetic mechanisms, such as DNA methylation, have recently gained attention as aetiological...

Author(s)
Ishizaki, T.; Yamazaki, J.; Jelinek, J.; Aoshima, K.; Kimura, T.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2020, 132, pp 521-526
Abstract

Canine melanoma is a frequently-occuring neoplasm in dogs and presents as malignant and highly metastatic in this context, studies that contribute to the understanding of the tumor microenvironment in melanoma include the role of galectins. Galectins are proteins of the family of animal lectins...

Author(s)
Garcia, J. S.; Hazarbassanov, N. G. T. Q.; Nakamura, J. C.; Nowosh, V.; Cogliati, B.; Sá, L. R. M. de; Massoco, C. O.
Publisher
Colégio Brasileiro de Patologia Animal, Rio de Janeiro, Brazil
Citation
Pesquisa Veterinária Brasileira, 2020, 40, 12, pp 1010-1017
Abstract

Although numerous animal models, especially mouse models, have been established for the study of melanoma, they often fail to accurately describe the mechanisms of human disease because of their anatomic, physiological, and immune differences. The dog, as a spontaneous model of melanoma, is...

Author(s)
Sforna, M.; Chiaradia, E.; Porcellato, I.; Silvestri, S.; Moretti, G.; Mechelli, L.; Brachelente, C.
Publisher
MDPI AG, Basel, Switzerland
Citation
Animals, 2021, 11, 3,
Abstract

Canine oral malignant melanoma (COMM) is considered a chemo-resistant cancer with a poor long-term prognosis. The melanoma-associated antigen A (MAGE-A) genes, which belong to the cancer-testis antigen family, are expressed in several different canine cancers but not in normal somatic tissue. This...

Author(s)
Guillén, A.; Stiborova, K.; Ressel, L.; Blackwood, L.; Finotello, R.; Amores-Fuster, I.; Jama, N.; Killick, D.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2021, 137, pp 226-234
Abstract

Despite promising immunotherapy strategies in human melanoma, there are few studies on the immune environment of canine melanocytic tumors. In humans, the activation of immunosuppressive cell subpopulations, such as regulatory T cells (Tregs) that express forkhead box protein P3 (FoxP3), the...

Author(s)
Porcellato, I.; Brachelente, C.; Cappelli, K.; Menchetti, L.; Silvestri, S.; Sforna, M.; Mecocci, S.; Iussich, S.; Leonardi, L.; Mechelli, L.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2021, 58, 1, pp 42-52
Abstract

MLN4924 (pevonedistat) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor. The NEDD8-regulated neddylation system is responsible for the regulated degradation of intracellular proteins with important cellular functions in cancer cell growth, apoptosis, angiogenesis and metastasis. In ...

Author(s)
Wood, E. A.; Lu ZhanPing; Jia Shuai; Assumpção, A. L. F. V.; Hesteren, M. A. van; Huelsmeyer, M. K.; Vail, D. M.; Pan Xuan
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2020, 18, 3, pp 269-280
Abstract

Canine melanoma is a frequent neoplasm in dogs. It has a malignant, invasive and metastatic potential. In this context, studies about the involvement of galectins are justified to increase the knowledge of melanoma tumor microenvironment. Galectins are proteins of the animal lectins family, that...

Author(s)
Garcia, J. S. G.
Publisher
Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, Brazil
Citation
Avaliação da expressão das galectinas no melanoma canino, 2017, pp 96 pp.
Abstract

BRCA1-associated protein-1 (BAP1) is a nuclear localized deubiquitylating enzyme that belongs to the ubiquitin c-terminal hydrolase subfamily. The encoded protein is highly homologous between man and dogs, suggesting a functional significance preserved by evolution. BAP1 has multiple properties,...

Author(s)
Jama, N.; Farquhar, N.; Butt, Z.; Coupland, S. E.; Sacco, J. J.; Scase, T.; Fielding, A. B.; Coulson, J. M.; Kalirai, H.; Killick, D. R.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Comparative Pathology, 2018, 162, pp 50-58

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