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Abstract

Canine melanoma is a frequent neoplasm in dogs. It has a malignant, invasive and metastatic potential. In this context, studies about the involvement of galectins are justified to increase the knowledge of melanoma tumor microenvironment. Galectins are proteins of the animal lectins family, that...

Author(s)
Garcia, J. S. G.
Publisher
Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, Brazil
Citation
Avaliação da expressão das galectinas no melanoma canino, 2017, pp 96 pp.
Abstract

BRCA1-associated protein-1 (BAP1) is a nuclear localized deubiquitylating enzyme that belongs to the ubiquitin c-terminal hydrolase subfamily. The encoded protein is highly homologous between man and dogs, suggesting a functional significance preserved by evolution. BAP1 has multiple properties,...

Author(s)
Jama, N.; Farquhar, N.; Butt, Z.; Coupland, S. E.; Sacco, J. J.; Scase, T.; Fielding, A. B.; Coulson, J. M.; Kalirai, H.; Killick, D. R.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Comparative Pathology, 2018, 162, pp 50-58
Abstract

Melanoma in humans and canines is an aggressive and highly metastatic cancer. The mucosal forms in both species share genetic and histopathologic features, making dogs a valuable spontaneous disease animal model. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells of...

Author(s)
Hutchison, S.; Sahay, B.; Mello, S. C. H. de; Sayour, E. J.; Lejeune, A.; Szivek, A.; Livaccari, A. M.; Fox-Alvarez, S.; Salute, M.; Powers, L.; Milner, R. J.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2019, 216, pp 109912
Abstract

Canine oral mucosal melanoma is an aggressive malignant neoplasm and is characterized by local infiltration and a high metastatic potential. The disease progression is similar to that of human oral melanomas. Whereas human cutaneous melanoma is primarily driven by activating mutations in Braf (60%) ...

Author(s)
Lee, B. H.; Neela, P. H.; Kent, M. S.; Zehnder, A. M.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2017, 12, 4, pp e0176370
Abstract

Objectives: A xenogeneic human tyrosinase DNA vaccine was developed for treatment of dogs with oral malignant melanoma (Oncept; Merial). No studies have evaluated the safety or efficacy of this vaccine in cats. The purpose of this study was to evaluate the safety of the canine melanoma vaccine in...

Author(s)
Sarbu, L.; Kitchell, B. E.; Bergman, P. J.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Feline Medicine and Surgery, 2017, 19, 2, pp 224-230
AbstractFull Text

Canine oral malignant melanoma (CoMM) is a highly aggressive tumor associated with a poor survival due to both local disease progression and high metastatic potential. Radiotherapy is often applied as the treatment for dogs with melanoma. However, the therapeutic effect of it may be limited due to...

Author(s)
Wada, Y.; Noguchi, S.; Nishiyama, Y.; Matsuyama, S.; Mori, T.; Igase, M.; Mizuno, T.; Shimamura, S.; Shimada, T.
Publisher
Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
Citation
Japanese Journal of Veterinary Research, 2019, 67, 2, pp 151-161
Abstract

Canine malignant melanoma (MM) is a highly aggressive tumour with a low survival rate and represents an ideal spontaneous model for the human counterpart. Considerable progress has been recently obtained, but the therapeutic success for canine melanoma is still challenging. Little is known about...

Author(s)
Giannuzzi, D.; Marconato, L.; Elgendy, R.; Ferraresso, S.; Scarselli, E.; Fariselli, P.; Nicosia, A.; Pegolo, S.; Leoni, G.; Laganga, P.; Leone, V. F.; Giantin, M.; Troise, F.; Dacasto, M.; Aresu, L.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2019, 17, 3, pp 308-316
Abstract

MCAM/CD146 (melanoma cell adhesion molecule/CD146) is a transmembrane immunoglobulin superfamily cell adhesion molecule involved in transendothelial migration and signal transduction. It is expressed in melanoma, squamous cell carcinoma, prostatic, ovarian, cervical and endometrial cancers and...

Author(s)
Asa, S. A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Comparative Pathology, 2017, 157, 1, pp 27-33
Abstract

Canine malignant melanoma, a significant cause of mortality in domestic dogs, is a powerful comparative model for human melanoma, but little is known about its genetic etiology. We mapped the genomic landscape of canine melanoma through multi-platform analysis of 37 tumors (31 mucosal, 3 acral, 2...

Author(s)
Hendricks, W. P. D.; Zismann, V.; Karthigayini Sivaprakasam; Legendre, C.; Poorman, K.; Tembe, W.; Perdigones, N.; Kiefer, J.; Liang, W.; DeLuca, V.; Stark, M.; Ruhe, A.; Froman, R.; Duesbery, N. S.; Washington, M.; Aldrich, J.; Neff, M. W.; Huentelman, M. J.; Hayward, N.; Brown, K.; Thamm, D.; Post, G.; Chand Khanna; Davis, B.; Breen, M.; Sekulic, A. (et al)
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS Genetics, 2018, 14, 9, pp e1007589
Abstract

Human melanoma is one of the deadliest forms of cancer, with poor prognosis and high resistance to chemotherapy and radiotherapy. The discovery of immunosuppressive mechanisms in the human melanoma microenvironment led to the use of new prognostic markers and to the development of immunotherapies...

Author(s)
Porcellato, I.; Brachelente, C.; Paolis, L. de; Menchetti, L.; Silvestri, S.; Sforna, M.; Vichi, G.; Iussich, S.; Mechelli, L.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2019, 56, 2, pp 189-199

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