Background: We previously reported regenerative therapies for decompensated cirrhosis based on peripheral venous drip infusion using non-cultured whole bone marrow (BM) cells, or the less invasive cultured BM-derived mesenchymal stem cells (BMSCs). Here, we assessed the efficacy and safety of ...

The aim of the study was to assess serum hyaluronic acid (HA) and transforming growth factor beta 1 (TGF-β1) concentrations: (1) to differentiate hepatic fibrosis from other forms of liver disease, and (2) for the non-invasive staging of canine liver fibrosis. We also evaluated the association...

Accurate staging of hepatic fibrosis (HF) is important for treatment and prognosis of canine chronic hepatitis. HF scores are used in human medicine to indirectly stage and monitor HF, decreasing the need for liver biopsy. We developed a canine HF score to screen for moderate or greater HF. We...

Liver cirrhosis represents the final pathway of all chronic hepatic injury. Replacement the damaged hepatocytes through cell-based therapies have been a promising therapeutic agent for tissue regeneration. This study aimed to assess the effect of treatment with Hepatocyte Differentiated Mesenchymal ...

Idiopathic hepatic fibrosis (İHF) is an inevitable result of chronic liver disease progressing to cirrhosis. Idiopathic Hepatic fibrosis is characterized as congenital or juvenile form in German Shepherd Dogs. However, few data have been published on the incidence and prevalence of IHF in canine...

Background: Magnetic resonance imaging using gadoxetic acid, a hepatocyte-specific contrast agent, is one of the most useful MRI techniques used to diagnose liver tumours in humans. During the hepato-biliary phase, there is uptake of gadoxetic acid by normal hepatocytes, leading to hepatic...

Glycogen storage disease type IIIa (GSD IIIa) is caused by a deficiency of glycogen debranching enzyme activity. Hepatomegaly, muscle degeneration, and hypoglycemia occur in human patients at an early age. Long-term complications include liver cirrhosis, hepatic adenomas, and generalized myopathy....

Background: Endothelin (ET)-1 is a 21-amino-acid peptide with potent vasoactive properties, which increases intrahepatic resistance in patients with chronic hepatitis (CH) or cirrhosis. ET-1 concentrations have not been investigated in dogs with CH. Hypothesis/Objectives: This study compared ...

Ultrasound is an examination method of choice when investigating hepatic disorders. This technique allows the size and shape of the liver to be evaluated, as well as revealing anomalies of the hepatic parenchyma, the biliary tract and vascularization. However an absence of changes in the...

Background and Aim: To assess liver fibrosis stages in a liver fibrosis-early cirrhosis model in dogs, the clinical efficiency of contrast-enhanced ultrasound (CEUS) and computed tomography (CT) perfusion imaging were compared. Methods: Hepatic vein arriving time (HVAT), hepatic artery arriving...