Background: We previously reported regenerative therapies for decompensated cirrhosis based on peripheral venous drip infusion using non-cultured whole bone marrow (BM) cells, or the less invasive cultured BM-derived mesenchymal stem cells (BMSCs). Here, we assessed the efficacy and safety of ...
Author(s)
Nishimura, T.; Takami, T.; Sasaki, R.; Aibe, Y.; Matsuda, T.; Fujisawa, K.; Matsumoto, T.; Yamamoto, N.; Tani, K.; Taura, Y.; Sakaida, I.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 1, pp e0210588
The aim of the study was to assess serum hyaluronic acid (HA) and transforming growth factor beta 1 (TGF-β1) concentrations: (1) to differentiate hepatic fibrosis from other forms of liver disease, and (2) for the non-invasive staging of canine liver fibrosis. We also evaluated the association...
Author(s)
Ceplecha, V.; Řeháková, K.; Lendon, C.; Proks, P.; Škorič, M.; Grinwis, G. C. M.; Hřibová, B.; Vávra, M.; Lorenzová, J.; Crha, M.
Publisher
University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
Citation
Acta Veterinaria Brno, 2018, 87, 3, pp 231-240
Liver cirrhosis represents the final pathway of all chronic hepatic injury. Replacement the damaged hepatocytes through cell-based therapies have been a promising therapeutic agent for tissue regeneration. This study aimed to assess the effect of treatment with Hepatocyte Differentiated Mesenchymal ...
Author(s)
Hassan, M. H.; Shamaa, A. A.; Hassan, E. A.; El-Tookhy, O. S.; Elfatah, S. D. A.; Shehab, G. G.
Publisher
Knowledgia Review, Malaysia
Citation
Asian Journal of Animal Sciences, 2016, 10, 2, pp 120-130
Accurate staging of hepatic fibrosis (HF) is important for treatment and prognosis of canine chronic hepatitis. HF scores are used in human medicine to indirectly stage and monitor HF, decreasing the need for liver biopsy. We developed a canine HF score to screen for moderate or greater HF. We...
Author(s)
Menard, M.; Lecoindre, A.; Cadoré, J. L.; Chevallier, M.; Pagnon, A.; Hernandez, J.; Leal, R. O.; Hugonnard, M.; Miette, V.; Destro, M.; Rannou, B.; Benchekroun, G.; Lecoindre, P.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2019, 31, 5, pp 665-673
Idiopathic hepatic fibrosis (İHF) is an inevitable result of chronic liver disease progressing to cirrhosis. Idiopathic Hepatic fibrosis is characterized as congenital or juvenile form in German Shepherd Dogs. However, few data have been published on the incidence and prevalence of IHF in canine...
Author(s)
Algİhosseİnİ, H.; Çolakoğlu, E. Ç.; Kurtdede, A.; Haydardedeoğlu, A. E.
Publisher
Afyon Kocatepe University Faculty of Veterinary Medicine, Afyonkarahisar, Turkey
Citation
Kocatepe Veterinary Journal, 2018, 11, 4, pp 501-507
Primary hepatitis (PH) is one of the most frequently diagnosed hepatic diseases in dogs. Its popular forms are acute hepatitis (AH) and chronic active hepatitis (CAH) which can progress to hepatic fibrosis and cirrhosis. This investigation aimed to evaluate the use of hepatocyte released Canine...
Author(s)
El-Sebaey, A. M.; Abramov, P. N.; Borunova, S. M.
Publisher
Peoples' Friendship University of Russia (RUDN University), Moscow, Russia
Citation
RUDN Journal of Agronomy and Animal Industries, 2020, 15, 3, pp 294-307
Background: Magnetic resonance imaging using gadoxetic acid, a hepatocyte-specific contrast agent, is one of the most useful MRI techniques used to diagnose liver tumours in humans. During the hepato-biliary phase, there is uptake of gadoxetic acid by normal hepatocytes, leading to hepatic...
Author(s)
Borusewicz, P.; Stańczyk, E.; Kubiak, K.; Spużak, J.; Glińska-Suchocka, K.; Jankowski, M.; Sławuta, P.; Kubiak-Nowak, D.; Podgórski, P.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2019, 15, 293, pp (14 August 2019)
Icterus (jaundice) is a yellowish pigmentation resulting from the depositing of bilirubin in tissues due to its high plasmatic concentration. The pathogenesis of icterus includes metabolic changes or obstructed bilirubin excretion and it is classified as pre-hepatic, hepatic and post-hepatic. This...
Author(s)
Andrade, M. C.; Oliveira, L. B.; Santos, Á. F.; Moreira, M. V. L.; Pierezan, F.; Ecco, R.
Publisher
Colégio Brasileiro de Patologia Animal, Rio de Janeiro, Brazil
Citation
Pesquisa Veterinária Brasileira, 2020, 40, 6, pp 451-465
Background: Melatonin is a hormone produced and secreted primarily by the pineal gland and mainly metabolised in the liver. Increased melatonin concentrations have been reported in human cirrhosis and hepatic encephalopathy (HE), a syndrome of neurological dysfunction. The pathogenesis of canine HE ...
Author(s)
Ferreira, M. da F.; Mellanby, R. J.; Gow, A. G.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2020, 187, 3, pp e23-e23
Background: Endothelin (ET)-1 is a 21-amino-acid peptide with potent vasoactive properties, which increases intrahepatic resistance in patients with chronic hepatitis (CH) or cirrhosis. ET-1 concentrations have not been investigated in dogs with CH. Hypothesis/Objectives: This study compared ...
Author(s)
Sakamoto, Y.; Sakai, M.; Watari, T.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2017, 31, 3, pp 764-769