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Abstract

In order to assess the clinical utility of cGSTA as a novel biomarker for hepatocellular damage, serum samples from 45 dogs with hepatobiliary disease were assessed. With the exception of two dogs with a normal liver biopsy, but elevated liver enzymes, all of the diseased dogs had histopathological ...

Author(s)
Mischel, M.
Publisher
Mensch & Buch Verlag, Berlin, Germany
Citation
Purification and partial characterization of canine glutathione transferase alpha and the development of an immunoassay for the measurement of canine glutathione tranferase alpha concentration in serum, 2016, pp viii + 119 pp.
Abstract

The aim of the study was to assess serum hyaluronic acid (HA) and transforming growth factor beta 1 (TGF-β1) concentrations: (1) to differentiate hepatic fibrosis from other forms of liver disease, and (2) for the non-invasive staging of canine liver fibrosis. We also evaluated the association...

Author(s)
Ceplecha, V.; Řeháková, K.; Lendon, C.; Proks, P.; Škorič, M.; Grinwis, G. C. M.; Hřibová, B.; Vávra, M.; Lorenzová, J.; Crha, M.
Publisher
University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
Citation
Acta Veterinaria Brno, 2018, 87, 3, pp 231-240
Abstract

Background: Chronic hepatopathies present a diagnostic challenge, with different diseases being associated with similar clinical and laboratory findings. Characterization of dogs with chronic hepatopathies can be difficult and require costly diagnostic procedures such as acquisition of a liver...

Author(s)
Lawrence, Y. A.; Bishop, M. A.; Honneffer, J. B.; Cook, A. K.; Rodrigues-Hoffmann, A.; Steiner, J. M.; Suchodolski, J. S.; Lidbury, J. A.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2019, 33, 3, pp 1344-1352
Abstract

Extrahepatic-congenital portosystemic shunt is a vascular anomaly that connects the portal vein to the systemic circulation and leads to a change in hepatic microvascular perfusion. However, an assessment of hepatic microvascular perfusion is limited by conventional diagnostic modalities. The aim...

Author(s)
Tamura, M.; Ohta, H.; Nisa, K.; Osuga, T.; Sasaki, N.; Morishita, K.; Takiguchi, M.
Publisher
Wiley, Boston, USA
Citation
Veterinary Radiology & Ultrasound, 2019, 60, 2, pp 192-200
Abstract

Computed tomography angiography (CTA) and biochemical parameters cannot specify liver pathologies in dogs with congenital portosystemic shunts (CPSS) that are easily determined by invasive histopathology. This study aims to assess the possibility of using circulating serum canine familiaris (cfa)...

Author(s)
El-Sebaey, A. M.; Abramov, P. N.; Abdelhamid, F. M.
Publisher
MDPI AG, Basel, Switzerland
Citation
Veterinary Sciences, 2020, 7, 2,
AbstractFull Text

Idiopathic hepatic fibrosis (İHF) is an inevitable result of chronic liver disease progressing to cirrhosis. Idiopathic Hepatic fibrosis is characterized as congenital or juvenile form in German Shepherd Dogs. However, few data have been published on the incidence and prevalence of IHF in canine...

Author(s)
Algİhosseİnİ, H.; Çolakoğlu, E. Ç.; Kurtdede, A.; Haydardedeoğlu, A. E.
Publisher
Afyon Kocatepe University Faculty of Veterinary Medicine, Afyonkarahisar, Turkey
Citation
Kocatepe Veterinary Journal, 2018, 11, 4, pp 501-507
AbstractFull Text

Hepatic stellate cells play a crucial role in the development of liver fibrosis. In a damaged liver, stellate cells undergo activation, which is manifested as a change of their phenotype: differentiation of stellate cells to myofibroblast-type cells, expression of alpha-Smooth Muscle Actin, their...

Author(s)
Sobczak-Filipiak, M.; Szarek, J.; Czopowicz, M.; Galanty, M.; Dolka, I.; Trębacz, P.; Frymus, J.; Lechowski, R.
Publisher
Polskie Towarzystwo Nauk Weterynaryjnych, Lublin, Poland
Citation
Medycyna Weterynaryjna, 2018, 74, 6, pp 392-397
Abstract

Objectives: Increased whole blood manganese concentrations have been reported in humans with primary liver disease. Due to the neurotoxic effects of manganese, altered manganese homeostasis has been linked to the development of hepatic encephalopathy. Whole blood manganese concentrations are...

Author(s)
Kilpatrick, S.; Jacinto, A.; Foale, R. D.; Tappin, S. W.; Burton, C.; Frowde, P. E.; Elwood, C. M.; Powell, R.; Duncan, A.; Mellanby, R. J.; Gow, A. G.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Small Animal Practice, 2014, 55, 5, pp 241-246
Abstract

Non-alcoholic fatty liver disease (NAFLD) is a poorly understood multifactorial pandemic disorder. One of the hallmarks of NAFLD, hepatic steatosis, is a common feature in canine congenital portosystemic shunts. The aim of this study was to gain detailed insight into the pathogenesis of steatosis...

Author(s)
Bossche, L. van den; Schoonenberg, V. A. C.; Burgener, I. A.; Penning, L. C.; Schrall, I. M.; Kruitwagen, H. S.; Wolferen, M. E. van; Grinwis, G. C. M.; Kummeling, A.; Rothuizen, J.; Velzen, J. F. van; Stathonikos, N.; Molenaar, M. R.; Helms, B. J.; Brouwers, J. F. H. M.; Spee, B.; Steenbeek, F. G. van
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2017, 12, 10, pp e0186491
Abstract

Chronic hepatic disease can present a diagnostic challenge with different etiologies being associated with similar clinical and laboratory findings. The histopathological assessment of a liver biopsy specimen is usually required in order to make a definitive diagnosis and the availability of...

Author(s)
Lawrence, Y. A.; Guard, B. C.; Steiner, J. M.; Suchodolski, J. S.; Lidbury, J. A.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 5, pp e0217797

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