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Abstract

In veterinary medicine levetiracetam (LEV) is a well-tolerated antiepileptic drug (AED) with only mild to moderate side effects. Behavioral changes are rarely reported in animals. In contrast, in human medicine the impact of LEV on behavior has frequently been described. Since in the Clinic for...

Author(s)
Erath, J. R.; Nessler, J. N.; Riese, F.; Hünerfauth, E.; Rohn, K.; Tipold, A.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2020, 6, April,
Abstract

Treatment of canine epilepsy is problematic. Few antiepileptic drugs have proven efficacy in dogs and undesirable adverse effects and pharmacoresistance are not uncommon. Consequently, the need for investigation of alternative treatment options is ongoing. The objective of this study was to...

Author(s)
Fredsø, N.; Sabers, A.; Toft, N.; Møller, A.; Berendt, M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2016, 208, pp 44-49
AbstractFull Text

Seizures are one of the most difficult symptoms to control during intoxication because many drugs used have severe effects on the patient's behavior and significantly affect their mental state. The use of levetiracetam in the treatment of seizures in a canine intoxicated with organophosphate is...

Author(s)
Molina-Díaz, V. M.; Duque-Muñoz, L.
Publisher
Universidad de Caldas, Manizales, Colombia
Citation
Veterinaria y Zootecnia, 2016, 10, 2, pp 15-26
Abstract

This study used a cross-sectional survey designed to inquire about antiepileptic drug (AED) use in newly diagnosed idiopathic epileptic dogs among board-certified emergency and neurology specialists. Results were obtained from 300 completed surveys by 128 board-certified neurologists and 172...

Author(s)
Meland, T.; Carrera-Justiz, S.; Buckley, G. J.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2019, 55, 3, pp 138-143
Abstract

Background: Levetiracetam is an anticonvulsant used for control of canine epilepsy. An extended release preparation should improve dosing convenience. Objectives: To determine the disposition of extended release levetiracetam in normal dogs after single dosing. Animals: Pharmacokinetic study: 16...

Author(s)
Beasley, M. J.; Boothe, D. M.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2015, 29, 5, pp 1348-1353
Abstract

Background: Levetiracetam can be used for seizure control alone or in combination with other antiepileptic medications. A previous study achieved the minimum targeted serum drug concentration after rectal administration of levetiracetam in healthy dogs. The purpose of the present study was to...

Author(s)
Cagnotti, G.; Odore, R.; Gardini, G.; Amedeo, S.; Bertone, I.; Guerriero, G.; Lentini, L.; Dappiano, E.; D'Angelo, A.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2018, 14, 189, pp (18 June 2018)
Abstract

Objective: To determine plasma pharmacokinetics of levetiracetam after a single intravenous dose (60 mg/kg) in normal dogs using a high-performance liquid chromatography assay validated for canine plasma. Design: Pharmacokinetic study. Setting: A university-based canine research facility. Animals:...

Author(s)
Dewey, C. W.; Bailey, K. S.; Boothe, D. M.; Badgley, B. L.; Cruz-Espindola, C.
Publisher
Blackwell Publishing, Oxford, UK
Citation
Journal of Veterinary Emergency and Critical Care, 2008, 18, 2, pp 153-157
Abstract

To evaluate the efficacy and tolerability of levetiracetam monotherapy in dogs with structural epilepsy. Retrospective case series. Nineteen client-owned dogs with structural epilepsy. Seizure frequencies after initiation of treatment were used to evaluate the efficacy of levetiracetam monotherapy. ...

Author(s)
Kelly, D.; Raimondi, F.; Shihab, N.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2017, 181, 15, pp 401
Abstract

Background: Retrospective studies can complement information derived from double-blinded randomized trials. There are multiple retrospective studies reporting good efficacy and tolerability of the anti-epileptic drug levetiracetam (LEV) in human patients with epilepsy; however, reports of LEV's...

Author(s)
Packer, R. M. A.; Nye, G.; Porter, S. E.; Volk, H. A.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2015, 11, 25, pp (7 February 2015)
Abstract

Objective: To compare long-term clinical outcomes of dogs with single congenital extrahepatic portosystemic shunts (CEHPSS) treated with thin film banding (TFB) consisting of polyolefin fiber or ameroid ring constrictor (ARC) placement in dogs. Design: Retrospective, two-center clinical study....

Author(s)
Otomo, A.; Singh, A.; Jeong Junemoe; Dobberstein, R.; Lundhild, A.; Peter, E.; Brisson, B.; Oblak, M.; Milovancev, M.
Publisher
Wiley, Boston, USA
Citation
Veterinary Surgery, 2020, 49, 3, pp 436-444

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