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Veterinary information to support practice, based on evidence and continuing education

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Abstract

Rapid progress in knowledge of the organization of the dog genome has facilitated the identification of the mutations responsible for numerous monogenic diseases, which usually present a breed-specific distribution. The majority of these diseases have clinical and molecular counterparts in humans....

Author(s)
Switonski, M.
Publisher
Springer Berlin, Heidelberg, Germany
Citation
Journal of Applied Genetics, 2020, 61, 2, pp 179-186
Abstract

A 6-month-old, neutered male, mixed-breed dog was examined for a 2-month persistent fever, nonhealing dermal metacarpal area wound, and leukocytosis (47.0-198.0×103/µl). Serum chemistry findings included hypoalbuminemia, hyperglobulinemia, hyperphosphatemia, and hyperphosphatasemia. Complete blood...

Author(s)
Zimmerman, K. L.; McMillan, K.; Monroe, W. E.; Sponenberg, D. P.; Evans, N.; Makris, M.; Hammond, S. H.; Mullarky, I. K.; Boudreaux, M. K.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2013, 25, 2, pp 291-296
Abstract

Background: Leukocyte adhesion deficiency (LAD) or CD18 deficiency is an autosomal recessive immunodeficiency which has been described in people, cattle, dogs, and knockout mice. Objectives: The study goals were to characterize the clinicopathologic, immunologic, and molecular genetic features of...

Author(s)
Bauer, T. R., Jr.; Pratt, S. M.; Palena, C. M.; Raj, K.; Giger, U.
Publisher
Wiley, Boston, USA
Citation
Veterinary Clinical Pathology, 2017, 46, 3, pp 391-400
Abstract

Background: Leucocyte adhesion deficiencies are inherited disorders characterised by immunodeficiency leading to recurrent infections and a marked leucocytosis. We describe the clinical characteristics, diagnosis and management of an Australian mixed- breed dog with leucocyte adhesion deficiency...

Author(s)
Hugo, T. B.; Heading, K. L.
Publisher
Wiley-Blackwell, Melbourne, Australia
Citation
Australian Veterinary Journal, 2014, 92, 8, pp 299-302
Abstract

Canine leukocyte adhesion deficiency (CLAD) in Irish setters is caused by genetic defects of leukocyte integrin CD18 leading to recurrent bacterial infections. We report clinical features and analysis of neutrophil function from two mixed-breed canine littermates (one female and one male dog)...

Author(s)
Kobayashi, S.; Sato, R.; Abe, Y.; Inanami, O.; Yasui, H.; Omoe, K.; Yasuda, J.; Hankanga, C.; Oda, S.; Sasaki, J.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2009, 130, 3/4, pp 187-196
Abstract

Leukocyte adhesion deficiency-1 (LAD-1), a genetic immunodeficiency disease characterized by life-threatening bacterial infections, results from the defective adherence and migration of leukocytes due to mutations in the leukocyte integrin CD18 molecule. Canine LAD (CLAD) represents the canine...

Author(s)
Gu, Y. C.; Bauer, T. R.; Sokolic, R. A.; Hai, M.; Tuschong, L. M.; Burkholder, T.; Bacher, J.; Starost, M. F.; Hickstein, D. D.
Publisher
Nature Publishing Group, Basingstoke, UK
Citation
Bone Marrow Transplantation, 2006, 37, 6, pp 607-614
Abstract

Nonmyeloablative conditioning regimens are increasingly replacing myeolablative conditioning prior to allogeneic hematopoietic stem cell transplantation (SCT). The recent advent of these conditioning regimens has limited the assessment of the long-term effects of this treatment, including analysis...

Author(s)
Burkholder, T. H.; Colenda, L.; Tuschong, L. M.; Starost, M. F.; Bauer, T. R., Jr.; Hickstein, D. D.
Publisher
American Society of Hematology, Washington, USA
Citation
Blood, 2006, 108, 5, pp 1767-1769
Abstract

The genetic immunodeficiency disease canine leukocyte adhesion deficiency (CLAD) was originally described in juvenile Irish Setters with severe, recurrent bacterial infections. CLAD was subsequently shown to result from a mutation in the leukocyte integrin CD18 subunit which prevents leukocyte...

Author(s)
Creevy, K. E.; Bauer, T. R., Jr.; Tuschong, L. M.; Embree, L. J.; Colenda, L.; Cogan, K.; Starost, M. F.; Haskins, M. E.; Hickstein, D. D.
Publisher
Elsevier Science B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2003, 94, 1/2, pp 11-22
Abstract

Integration site analysis was performed on six dogs with canine leukocyte adhesion deficiency (CLAD) that survived greater than 1 year after infusion of autologous CD34+ bone marrow cells transduced with a gammaretroviral vector expressing canine CD18. A total of 387 retroviral insertion sites...

Author(s)
Hai, M.; Adler, R. L.; Bauer, T. R., Jr.; Tuschong, L. M.; Gu, Y. C.; Wu, X.; Hickstein, D. D.
Publisher
Nature Publishing Group, Basingstoke, UK
Citation
Gene Therapy, 2008, 15, 14, pp 1067-1071
Abstract

The genetic disease canine leukocyte adhesion deficiency (CLAD) is characterized by recurrent, severe bacterial infections, typically culminating in death by 6 months of age. CLAD is due to a mutation in the leukocyte integrin CD18 subunit, which prevents surface expression of the CD11/CD18 ...

Author(s)
Creevy, K. E.; Bauer, T. R., Jr.; Tuschong, L. M.; Embree, L. J.; Silverstone, A. M.; Bacher, J. D.; Romines, C.; Garnier, J.; Thomas, M. L., III; Colenda, L.; Hickstein, D. D.
Publisher
Elsevier Science B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2003, 95, 3/4, pp 113-121

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