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Abstract

Background: Leukocyte adhesion deficiency (LAD) or CD18 deficiency is an autosomal recessive immunodeficiency which has been described in people, cattle, dogs, and knockout mice. Objectives: The study goals were to characterize the clinicopathologic, immunologic, and molecular genetic features of...

Author(s)
Bauer, T. R., Jr.; Pratt, S. M.; Palena, C. M.; Raj, K.; Giger, U.
Publisher
Wiley, Boston, USA
Citation
Veterinary Clinical Pathology, 2017, 46, 3, pp 391-400
Abstract

Background: Leucocyte adhesion deficiencies are inherited disorders characterised by immunodeficiency leading to recurrent infections and a marked leucocytosis. We describe the clinical characteristics, diagnosis and management of an Australian mixed- breed dog with leucocyte adhesion deficiency...

Author(s)
Hugo, T. B.; Heading, K. L.
Publisher
Wiley-Blackwell, Melbourne, Australia
Citation
Australian Veterinary Journal, 2014, 92, 8, pp 299-302
Abstract

A 6-month-old, neutered male, mixed-breed dog was examined for a 2-month persistent fever, nonhealing dermal metacarpal area wound, and leukocytosis (47.0-198.0×103/µl). Serum chemistry findings included hypoalbuminemia, hyperglobulinemia, hyperphosphatemia, and hyperphosphatasemia. Complete blood...

Author(s)
Zimmerman, K. L.; McMillan, K.; Monroe, W. E.; Sponenberg, D. P.; Evans, N.; Makris, M.; Hammond, S. H.; Mullarky, I. K.; Boudreaux, M. K.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2013, 25, 2, pp 291-296
Abstract

Canine leukocyte adhesion deficiency (CLAD) in Irish setters is caused by genetic defects of leukocyte integrin CD18 leading to recurrent bacterial infections. We report clinical features and analysis of neutrophil function from two mixed-breed canine littermates (one female and one male dog)...

Author(s)
Kobayashi, S.; Sato, R.; Abe, Y.; Inanami, O.; Yasui, H.; Omoe, K.; Yasuda, J.; Hankanga, C.; Oda, S.; Sasaki, J.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2009, 130, 3/4, pp 187-196
Abstract

Leukocyte adhesion deficiency-1 (LAD-1), a genetic immunodeficiency disease characterized by life-threatening bacterial infections, results from the defective adherence and migration of leukocytes due to mutations in the leukocyte integrin CD18 molecule. Canine LAD (CLAD) represents the canine...

Author(s)
Gu, Y. C.; Bauer, T. R.; Sokolic, R. A.; Hai, M.; Tuschong, L. M.; Burkholder, T.; Bacher, J.; Starost, M. F.; Hickstein, D. D.
Publisher
Nature Publishing Group, Basingstoke, UK
Citation
Bone Marrow Transplantation, 2006, 37, 6, pp 607-614
Abstract

Integration site analysis was performed on six dogs with canine leukocyte adhesion deficiency (CLAD) that survived greater than 1 year after infusion of autologous CD34+ bone marrow cells transduced with a gammaretroviral vector expressing canine CD18. A total of 387 retroviral insertion sites...

Author(s)
Hai, M.; Adler, R. L.; Bauer, T. R., Jr.; Tuschong, L. M.; Gu, Y. C.; Wu, X.; Hickstein, D. D.
Publisher
Nature Publishing Group, Basingstoke, UK
Citation
Gene Therapy, 2008, 15, 14, pp 1067-1071
Abstract

Nonmyeloablative conditioning regimens are increasingly replacing myeolablative conditioning prior to allogeneic hematopoietic stem cell transplantation (SCT). The recent advent of these conditioning regimens has limited the assessment of the long-term effects of this treatment, including analysis...

Author(s)
Burkholder, T. H.; Colenda, L.; Tuschong, L. M.; Starost, M. F.; Bauer, T. R., Jr.; Hickstein, D. D.
Publisher
American Society of Hematology, Washington, USA
Citation
Blood, 2006, 108, 5, pp 1767-1769
Abstract

This special issue is a compilation of articles from various experts on animal genetics, genetic disorders and diagnostics. Topics discussed are: genetic testing in domestic cats; genetic testing for phenotype-causing variants in sheep and goats; coat colour DNA testing in dogs (theory meets...

Author(s)
Leeb, T.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Molecular and Cellular Probes, 2012, 26, 6, pp 223-262
Abstract

The genetic immunodeficiency disease canine leukocyte adhesion deficiency (CLAD) was originally described in juvenile Irish Setters with severe, recurrent bacterial infections. CLAD was subsequently shown to result from a mutation in the leukocyte integrin CD18 subunit which prevents leukocyte...

Author(s)
Creevy, K. E.; Bauer, T. R., Jr.; Tuschong, L. M.; Embree, L. J.; Colenda, L.; Cogan, K.; Starost, M. F.; Haskins, M. E.; Hickstein, D. D.
Publisher
Elsevier Science B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2003, 94, 1/2, pp 11-22
Abstract

Canine leukocyte adhesion deficiency (CLAD) is a primary immunodeficiency disease characterized by recurrent bacterial infections in the presence of marked leukocytosis. The disease was first described in the mid-1980s in a cross-breed Irish Setter Dog in the United States. It results from a...

Author(s)
Foureman, P.; Whiteley, M.; Giger, U.
Publisher
American College of Veterinary Internal Medicine, Lakewood, USA
Citation
Journal of Veterinary Internal Medicine, 2002, 16, 5, pp 518-523

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