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Abstract

The B-cell coreceptor, CD19 is a transmembrane protein expressed throughout B-cell ontogeny from pro-B cell to plasmablast. It plays an important role in B-cell development and function and is an attractive target for antibody-directed immunotherapies against B-cell malignancies, including acute...

Author(s)
Haran, K. P.; Lockhart, A.; Xiong, A.; Radaelli, E.; Savickas, P. J.; Posey, A.; Mason, N. J.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2020, 57, 2, pp 241-252
AbstractFull Text

The aim of the present study was to analyse epidemiological, cytological, laboratory and clinical data from canine acute leukemia (AL) cases. The study was conducted from 2009 to 2015, and included 2384 dogs undergoing cytological examination in two veterinary practices in Warsaw. The analysis...

Author(s)
Sapierzyński, R.; Huć, T.; Czopowicz, M.; Jankowska, U.; Jagielski, D.; Kliczkowska-Klarowicz, K.
Publisher
Polskie Towarzystwo Nauk Weterynaryjnych, Lublin, Poland
Citation
Medycyna Weterynaryjna, 2017, 73, 2, pp 118-123
Abstract

T-cell large granular lymphocytic leukemia (T-cell LGLL) is the most common presentation of chronic lymphocytic leukemia (CLL) in dogs. Aleukemic or subleukemic leukemia is a particularly rare variation in both humans and dogs, where bone marrow proliferation is either not or only sparsely...

Author(s)
Museux, K.; Turinelli, V.; Rosenberg, D.; Piñeiro, I. R.
Publisher
Wiley, Boston, USA
Citation
Veterinary Clinical Pathology, 2019, 48, 4, pp 721-724
Abstract

Introduction: Methotrexate is an antimetabolite used in the treatment of cancer and non-malignant diseases including rheumatoid arthritis, psoriasis and graft vs. host disease. Combination therapy with methotrexate was successful in the treatment of canine lymphoma, mammary tumor and invasive...

Author(s)
Pawlak, A.; Kutkowska, J.; Obmińska-Mrukowicz, B.; Rapak, A.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Research in Veterinary Science, 2017, 114, pp 518-523
Abstract

X-chromosome inactivation pattern (XCIP) analysis has been widely used to assess cell clonality in various types of human neoplasms. In this study, a polymerase chain reaction-based canine XCIP analysis of the androgen receptor (AR) gene was applied for the assessment of cell clonality in canine...

Author(s)
Mochizuki, H.; Goto-Koshino, Y.; Takahashi, M.; Fujino, Y.; Ohno, K.; Tsujimoto, H.
Publisher
American College of Veterinary Pathologists Inc., Lawrence, USA
Citation
Veterinary Pathology, 2015, 52, 1, pp 61-69
Abstract

Background: Immunophenotyping has replaced cytochemical staining as the preferred technique for classifying acute leukemia. However, some acute myeloid leukemias (AML) lack lineage-associated markers. In our experience, alkaline phosphatase (ALP) is expressed in immature canine monocytes. We...

Author(s)
Stokol, T.; Schaefer, D. M.; Shuman, M.; Belcher, N.; Dong, L.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Veterinary Clinical Pathology, 2015, 44, 1, pp 79-93
Abstract

Acute myeloid leukaemia (AML) is an uncommon, rapidly progressive neoplasm in dogs. The aim of this retrospective study was to characterize the clinical presentation, haematologic findings, diagnostic imaging results, treatment and survival time of a contemporary cohort of dogs with AML. Diagnosis...

Author(s)
Davis, L. L.; Hume, K. R.; Stokol, T.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 2, pp 268-275
Abstract

Acute myeloid leukemia is an uncommon hematopoietic neoplasm of dogs that should be differentiated from lymphoid neoplasms, such as lymphoma, because of different treatment protocols and a worse prognosis. Thoracic radiography is performed frequently in dogs with suspected hematopoietic neoplasia,...

Author(s)
Epperly, E.; Hume, K. R.; Moirano, S.; Stokol, T.; Intile, J.; Erb, H. N.; Scrivani, P. V.
Publisher
Wiley, Boston, USA
Citation
Veterinary Radiology & Ultrasound, 2018, 59, 5, pp 507-515
Abstract

Current therapies are insufficient for metastatic prostate cancer (PCa) in men and dogs. As human castrate-resistant PCa shares several characteristics with the canine disease, comparative evaluation of novel therapeutic agents is of considerable value for both species. Novel isoquinolinamine FX-9...

Author(s)
Schille, J. T.; Nolte, I.; Packeiser, E. M.; Wiesner, L.; Hein, J. I.; Weiner, F.; Wu XiaoFeng; Beller, M.; Junghanss, C.; Escobar, H. M.
Publisher
MDPI AG, Basel, Switzerland
Citation
International Journal of Molecular Sciences, 2019, 20, 22, pp 5567
Abstract

Hyaluronan receptor CD44 mediates interaction between cells and extracellular matrix. The expression of standard form and its variants is dysregulated in human leukemias and is associated with metastasis and prognosis. The aim of this work is the evaluation of CD44 mRNA and protein expression in ...

Author(s)
Gelain, M. E.; Martini, V.; Giantin, M.; Aricò, A.; Poggi, A.; Aresu, L.; Riondato, F.; Dacasto, M.; Comazzi, S.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2014, 159, 1/2, pp 91-96

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