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Abstract

The antineoplastic agent cyclophosphamide (CP) has dose-limiting side effects including sterile haemorrhagic cystitis (SHC), bone marrow (BM) suppression and gastrointestinal (GI) toxicity in dogs. The metabolites acrolein and phosphoramide that mediate these toxicities are...

Author(s)
Ekena, J.; Wood, E.; Manchester, A.; Chun, R.; Trepanier, L. A.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 4, pp 529-534
Abstract

The DMAC protocol (dexamethasone, melphalan, actinomycin-D, cytarabine) has been evaluated in American studies for the treatment of relapsed canine lymphoma, comparing similarly to other rescue protocols. The aim of this study was to evaluate efficacy and toxicity of DMAC, in a larger UK cohort of...

Author(s)
Smallwood, K.; Tanis, J. B.; Grant, I. A.; Blackwood, L.; Killick, D. R.; Amores-Fuster, I.; Elliott, J.; Mas, A.; Harper, A.; Marrington, M.; Finotello, R.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2019, 17, 2, pp 165-173
Abstract

Visual impairment from radiation-induced damage can be painful, disabling, and reduces the patient's quality of life. Ocular tissue damage can result from the proximity of ocular organs at risk to irradiated sinonasal target volumes. As toxicity depends on the radiation dose delivered to a certain...

Author(s)
Wolf, F.; Meier, V. S.; Pot, S. A.; Bley, C. R.
Publisher
Wiley, Boston, USA
Citation
Veterinary Ophthalmology, 2020, 23, 4, pp 596-610
Abstract

In order to overcome the common local treatment failure of canine sinonasal tumours, integrated boost techniques were tried in the cobalt/orthovoltage era, but dismissed because of unacceptable early (acute) toxicity. Intriguingly, a recent calculation study of a simultaneously integrated boost...

Author(s)
Soukup, A.; Meier, V.; Pot, S.; Voelter, K.; Bley, C. R.
Publisher
Wiley, Oxford, UK
Citation
Veterinary and Comparative Oncology, 2018, 16, 4, pp 441-449
Abstract

Visceral leishmaniasis VL, caused by digenetic protozoa of the genus Leishmania, is the most severe form of leishmaniasis. Leishmania infantum is one of the species responsible for VL and the disease caused is considered a zoonosis whose main reservoir is the dog. Canine visceral leishmaniasis CVL...

Author(s)
Gonçalves, A. A. M.; Leite, J. C.; Resende, L. A.; Silveira Mariano, R. M. da; Silveira, P.; Oliveira Melo-Júnior, O. A. de; Ribeiro, H. S.; Oliveira, D. S. de; Soares, D. F.; Santos, T. A. P.; Marques, A. F.; Galdino, A. S.; Martins-Filho, O. A.; Dutra, W. O.; Silveira-Lemos, D. da; Giunchetti, R. C.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Cellular and Infection Microbiology, 2019, 9, December,
AbstractFull Text

Canine MDR1 gene mutations produce translated P-glycoprotein, an active drug efflux transporter, resulting in dysfunction or over-expression. The 4-base deletion at exon 4 of MDR1 at nucleotide position 230 (nt230[del4]) in exon 4 makes P-glycoprotein lose function, leading to drug accumulation and ...

Author(s)
Lee JihJong; Lin HanYou; Chen ChunAn; Lin ChenSi; Wang LihChiann
Publisher
Korean Society of Veterinary Science, Seoul, Korea Republic
Citation
Journal of Veterinary Science, 2019, 20, 1, pp 27-33
Abstract

The use of natural products is a promising approach for treating visceral leishmaniosis. (-)-α-Bisabolol is a sesquiterpene that have been proved active in vivo on Leishmania infantum-infected mice without showing toxicity. A single-centre, parallel-group, randomized, exploratory study was designed ...

Author(s)
Corpas-López, V.; Merino-Espinosa, G.; Acedo-Sánchez, C.; Díaz-Sáez, V.; Navarro-Moll, M. C.; Morillas-Márquez, F.; Martín-Sánchez, J.
Publisher
Springer, Dordrecht, Netherlands
Citation
Veterinary Research Communications, 2018, 42, 2, pp 121-130
Abstract

Lead (Pb)-poisoning is a serious public health concern and dogs have been useful as a sentinel-animal for Pb exposure of humans. In the present study, the blood Pb concentrations (BLC), isotope ratios (208 Pb/206 Pb and 207 Pb/206 Pb), and biochemistry of 120 domestically owned dogs living around a ...

Author(s)
Toyomaki, H.; Yabe, J.; Nakayama, S. M. M.; Yohannes, Y. B.; Muzandu, K.; Liazambi, A.; Ikenaka, Y.; Kuritani, T.; Nakagawa, M.; Ishizuka, M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Chemosphere, 2020, 247,
Abstract

Lead is a heavy dense metal inducing toxicity especially in young animals and children. We describe effects of calcium disodium and thiamine on sub-chronic lead acetate drench in dogs assessed by serum malondialdehyde, gluthathione and comet assay for DNA damage. Groups of 5 pound dogs each were...

Author(s)
Owain, M. S.; Yousif, A. A.
Publisher
Online Journal of Veterinary Research, Toowoomba, Australia
Citation
Online Journal of Veterinary Research, 2018, 22, 5, pp 362-368
Abstract

Background: P-glycoprotein is a multidrug resistance (MDR) transporter, a member of the ATP binding cassette (ABC) family and is highly expressed in capillary endothelial cells in the brain. Its physiological function is to protect the body from potentially toxic compounds. In certain dog breeds a...

Author(s)
Palócz, O.; Benedek-Major, K.; Csigó, B.; Csikó, G.
Publisher
Herman Ottó Institute Nonprofit Ltd., Budapest, Hungary
Citation
Magyar Állatorvosok Lapja, 2018, 140, 8, pp 495-500

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