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VetMed Resource

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Abstract

Background: Mammary gland tumor is the most common spontaneous tumor in intact female dogs, and its poor prognosis remains a clinical challenge. Ivermectin, a well-known anti-parasitic agent, has been implicated as a potential anticancer agent in various types of human cancer. However, there are no ...

Author(s)
Diao HongXiu; Cheng Nan; Zhao Ying; Xu HuiHao; Dong HaoDi; Thamm, D. H.; Zhang Di; Lin DeGui
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2019, 15, 276, pp (2 August 2019)
Abstract

Vincristine is the first-line drug for the chemotherapy of canine transmissible venereal tumor (CTVT). Drug resistance is related to tumor cyto-morphological patterns of CTVT. There are anti-cancer properties of ivermectin, thus, a combination of ivermectin and vincristine could be an effective...

Author(s)
Bulhosa, L. F.; Estrela-Lima, A.; Solcà, M. da S.; Gonçalves, G. S. D.; Larangeira, D. F.; Pinho, F. A. de; Barrouin-Melo, S. M.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Animal Reproduction Science, 2020, 216,
Abstract

Twenty-two dogs diagnosed with canine heartworm disease (HWD) were classified into four groups (Class 1 [11 dogs], Class 2 [5 dogs], Class 3 [5 dogs], and Class 4 [1 dog]). Treatment was attempted with oral doxycycline and ivermectin combined with a single injection of melarsomine. The mean...

Author(s)
Ikemizu, T.; Shirahama, J.
Publisher
Japanese Society of Clinical Veterinary Medicine, Tottori, Japan
Citation
Journal of Animal Clinical Medicine, 2017, 26, 1, pp 16-23
Abstract

Advocate® (2.5% moxidectin+10% imidacloprid) (Bayer HealthCare, Leverkusen, Germany) is a multiparasiticidal spot-on authorized for treating canine demodicosis in many countries. This blinded, randomized three-phase clinical trial compared its efficacy employing different dosing regimens with that...

Author(s)
Paterson, T. E.; Halliwell, R. E.; Fields, P. J.; Louw, M. L.; Ball, G.; Louw, J.; Pinckney, R.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Parasitology, 2014, 205, 3/4, pp 687-696
Abstract

The purpose of this study was to determine the pharmacokinetic interaction between ivermectin (0.4 mg/kg) and praziquantel (10 mg/kg) administered either alone or co-administered to dogs after oral treatment. Twelve healthy cross-bred dogs (weighing 18-21 kg, aged 1-3 years) were allocated randomly ...

Author(s)
Ozdemir, Z.; Faki, H. E.; Uney, K.; Tras, B.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2019, 42, 5, pp 497-504
Abstract

Background: The safety of ProHeart® 12 (PH 12; extended-release injectable suspension; 10% moxidectin in glyceryl tristearate microspheres) was evaluated in four studies using Beagle dogs and one study using ivermectin-sensitive Collies. The recommended dose is 0.5 mg/kg subcutaneously once yearly. ...

Author(s)
Krautmann, M. J.; Mahabir, S.; Fielder, A.; Collard, W.; Wolthuis, T. L.; Esch, K.; Morton, T.; Alleman, K.; Luo LaiBin; McCandless, E.; Nederveld, S.; Kryda, K.; Carroll, R.; Boucher, J. F.
Publisher
BioMed Central Ltd, London, UK
Citation
Parasites and Vectors, 2019, 12, 433, pp (06 September 2019)
Abstract

This case report describes ivermectin-induced blindness in a dog and a foal with normal ophthalmic fundic examinations and attenuated electroretinography (ERG). Subsequent recovery in ERG was noted following intravenous lipid emulsion (ILE) therapy. A dog and a foal were evaluated for ...

Author(s)
Pollio, D.; Michau, T. M.; Weaver, E.; Kuebelbeck, K. L.
Publisher
Wiley, Boston, USA
Citation
Veterinary Ophthalmology, 2018, 21, 1, pp 82-87
Abstract

Afoxolaner is a novel insecticidal and acaricidal of the isoxazoline family, which is used in veterinary practice to control infestation of dogs by fleas, ticks, and mites (NexGard, Boehringer Ingelheim). Ivermectin is an avermectin administered at microdoses to prevent infection of dogs with ...

Author(s)
Tinkruejeen, G.; Meesaimongkon, P.; Tangtrongsup, S.; Thitaram, N.; Srifawattana, N.; Beugnet, F.; Tiwananthagorn, S.
Publisher
Elsevier, Amsterdam, Netherlands
Citation
Veterinary Parasitology: Regional Studies and Reports, 2019, 18, pp 100340
Abstract

P-glycoprotein (P-gp), encoded by the ABCB1 (MDR1) gene, dramatically impacts drug disposition. P-gp is expressed in the intestines, biliary canaliculi, renal tubules, and brain capillaries where it functions to efflux substrate drugs. In this capacity, P-gp restricts oral absorption, enhances...

Author(s)
Mealey, K. L.; Dassanayake, S.; Burke, N. S.
Publisher
Wiley, Oxford, UK
Citation
Journal of Veterinary Pharmacology and Therapeutics, 2017, 40, 5, pp 545-551
Abstract

Objective: To describe the use of single pass lipid dialysis (SPLD) for treatment of ivermectin toxicosis in 2 Australian Shepherd dogs with the ABCB1-1Δ gene mutation. Case Series Summary: Two Australian Shepherd dogs were presented for treatment of ivermectin toxicosis. Dogs were initially...

Author(s)
Londoño, L. A.; Buckley, G. J.; Bolfer, L.; Bandt, C.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Emergency and Critical Care, 2017, 27, 2, pp 232-237

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