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Abstract

OBJECTIVE: To develop a technique for isolation and culture of canine insulinoma cells and assess expression of cellular hexokinases (glucokinase and hexokinase I) and expression and secretion of insulin from these cells in vitro. SAMPLE: Pancreatic insulinomas and normal pancreatic tissue from 4...

Author(s)
Suwitheechon, O.; Schermerhorn, T.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2021, 82, 2, pp 110-117
Abstract

Twice-daily (BID) insulin injections are a major deterrence to owners treating dogs with diabetes mellitus (DM). The hypothesis for this study was that Protamine Zinc Recombinant Human Insulin (PZIR) is safe and efficacious as a once-daily (SID) treatment for canine DM. This was a prospective,...

Author(s)
Ward, C. R.; Christiansen, K.; Li, J.; Bryson, W. L.; Jerrentrup, K. A.; Kroh, C.
Publisher
Elsevier Inc, New York, USA
Citation
Domestic Animal Endocrinology, 2021, 75,
Abstract

The use of rapid-acting insulin analogs as routes of administration other than IV has never been described for the treatment of dogs with diabetic ketoacidosis (DKA). This study aims to compare the efficacy and safety of a new protocol based on IM administration of insulin lispro with that of...

Author(s)
Malerba, E.; Alessandrini, F.; Grossi, G.; Giunti, M.; Fracassi, F.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2020, 6, October,
Abstract

Mesenchymal stem cells (MSCs) possess regenerative and immunomodulatory properties and can control the immune dysregulation that leads to β-cell destruction. Stem-cell transplantation could thus manage insulin-dependent diabetes mellitus (IDDM) in dogs. In this pilot study, we aimed to assess ...

Author(s)
Rhew SungYong; Park SuMin; Li Qiang; An JuHyun; Chae HyungKyu; Lee JungHwa; Ahn JinOk; Song WooJin; Youn HwaYoung
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2021, 83, 4, pp 592-600
Abstract

Leptin and adiponectin are thought to modulate insulin sensitivity and pancreatic β-cell function, but there is limited information regarding the adipokine status of hyperglycemic dogs with hyperadrenocorticism. This study aimed to determine whether alterations in the leptin/adiponectin ratio, ...

Author(s)
Kim, H.; Kang, J. H.; Jung, D. I.; Kang, B. T.; Chang, D.; Yang, M. P.
Publisher
Elsevier Inc, New York, USA
Citation
Domestic Animal Endocrinology, 2021, 74,
Abstract

The aim of this study was to differentiate canine adipose-derived mesenchymal stem cells (ADMSCs) into insulin-producing cells by using culture media with different compositions to determine the most efficient media. Stem cells isolated from the fat tissues close to the bitch uterus were...

Author(s)
Camara, B. O. S.; Ocarino, N. M.; Bertassoli, B. M.; Malm, C.; Araújo, F. R.; Reis, A. M. S.; Jorge, E. C.; Alves, E. G. L.; Serakides, R.
Publisher
Elsevier Inc, New York, USA
Citation
Domestic Animal Endocrinology, 2021, 74,
AbstractFull Text

The aim of the study was to investigate the effect of Momordica charantia (MC) capsules combined with insulin hormone, restricted fat and high fiber diet on the treatment of diabetic dogs. In the present investigation eighteen clients owned diabetic dogs were divided into two groups and treated...

Author(s)
Surojit Das; Chandan Lodh
Publisher
Indian Society for Advancement of Canine Practice, Lucknow, India
Citation
Indian Journal of Canine Practice, 2019, 11, 2, pp 98-101
Abstract

Background: Canine diabetes mellitus (DM) is a common endocrine disease in domestic dogs. A number of pathological mechanisms are thought to contribute to the aetiopathogenesis of relative or absolute insulin deficiency, including immune-mediated destruction of pancreatic beta cells. DM risk varies ...

Author(s)
Denyer, A. L.; Massey, J. P.; Davison, L. J.; Ollier, W. E. R.; Catchpole, B.; Kennedy, L. J.
Publisher
BioMed Central Ltd, London, UK
Citation
Canine Medicine and Genetics, 2020, 7, 15, pp (31 October 2020)
Abstract

Insulin deficiency diabetes (IDD) in dogs is an endocrine disease similar to human type 1 diabetes. There are breeds more commonly affected, such as Yorkshire Terrier and Samoyed, suggesting an underlying genetic component. However, the genetic basis for canine diabetes mellitus (DM) is not fully...

Author(s)
Sanz, C. R.; Sevane, N.; Pérez-Alenza, M. D.; Valero-Lorenzo, M.; Dunner, S.
Publisher
Wiley, Oxford, UK
Citation
Animal Genetics, 2021, 52, 3, pp 333-341
Abstract

The commonly used sedative α2-adrenoceptor agonist dexmedetomidine has adverse cardiovascular effects in dogs that can be prevented by concomitant administration of the peripherally acting α2-adrenoceptor antagonist MK-467. An ancillary effect of dexmedetomidine is to decrease insulin release from...

Author(s)
Kallio-Kujala, I. J.; Bennett, R. C.; Raekallio, M. R.; Yatkin, E.; Meierjohann, A.; Savontaus, E.; Scheinin, M.; Spillmann, T.; Vainio, O. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2018, 242, pp 33-38

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