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Abstract

The issue of inherited disorders and poor health in pedigree dogs has been widely discussed in recent years. With the advent of genome-wide sequencing technologies and the increasing development of new diagnostic DNA disease tests, the full extent and prevalence of inherited disorders in pedigree ...

Author(s)
Farrell, L. L.; Schoenebeck, J. J.; Wiener, P.; Clements, D. N.; Summers, K. M.
Publisher
BioMed Central Ltd, London, UK
Citation
Canine Genetics and Epidemiology, 2015, 2, 3, pp (11 February 2015)
Abstract

Background: Canine DNA-testing has become an important tool in purebred dog breeding and many breeders use genetic testing results when planning their breeding strategies. In addition, information obtained from testing of hundreds dogs in one breed gives valuable information about the breed-wide...

Author(s)
Ahonen, S.; Seath, I.; Rusbridge, C.; Holt, S.; Key, G.; Wang, T.; Wang PeiXiang; Minassian, B. A.
Publisher
BioMed Central Ltd, London, UK
Citation
Canine Genetics and Epidemiology, 2018, 5, 2, pp (23 January 2018)
Abstract

AIMS: To explore veterinary perceptions of inherited disorders in pedigree dogs within New Zealand and how these affect animal health and welfare. METHODS: An online questionnaire was distributed to the 647 members of the Companion Animal Society of the New Zealand Veterinary Association using an...

Author(s)
Farrow, T.; Keown, A. J.; Farnworth, M. J.
Publisher
Taylor & Francis, Melbourne, Australia
Citation
New Zealand Veterinary Journal, 2014, 62, 5, pp 267-273
Abstract

Canine inherited factor VII deficiency is a mild-to-moderate, inherited coagulopathy that affects several breeds of dog. We identified 2 polymorphisms near the disease-causing F7 gene mutation, one of which interfered with testing in several Beagles by causing allele dropout of the normal,...

Author(s)
Ramirez, C. J.; Krug, M.; Zahand, A.; Sundin, K.; Shaffer, L. G.; Ballif, B. C.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2019, 31, 2, pp 276-279
Abstract

Background: A large and growing number of inherited genetic disease mutations are now known in the dog. Frequencies of these mutations are typically examined within the breed of discovery, possibly in related breeds, but nearly always in purebred dogs. No report to date has examined the frequencies ...

Author(s)
Zierath, S.; Hughes, A. M.; Fretwell, N.; Dibley, M.; Ekenstedt, K. J.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2017, 12, 11, pp e0188543
Abstract

The domestic dog serves as an excellent model to investigate the genetic basis of disease. More than 400 heritable traits analogous to human diseases have been described in dogs. To further canine medical genetics research, we established the Dog Biomedical Variant Database Consortium (DBVDC) and...

Author(s)
Jagannathan, V.; Drögemüller, C.; Leeb, T.
Publisher
Wiley, Oxford, UK
Citation
Animal Genetics, 2019, 50, 6, pp 695-704
Abstract

Canine hip dysplasia (CHD), canine elbow dysplasia (CED), and humeral head osteochondrosis (HHOC) are inherited traits with uneven incidence in dog breeds. Knowledge of the combined prevalence of these three disorders is necessary to estimate the effect of the currently applied breeding strategies, ...

Author(s)
Coopman, F.; Broeckx, B.; Verelst, E.; Deforce, D.; Saunders, J.; Duchateau, L.; Verhoeven, G.
Publisher
Schattauer GmbH, Stuttgart, Germany
Citation
Veterinary and Comparative Orthopaedics and Traumatology, 2014, 27, 5, pp 395-397
Abstract

The mapping of the canine genome and the study of canine breed genomic architecture has revolutionized the discovery of genetic tests for inherited disorders in dogs. As the genetics underlying complex disorders are revealed, canine breeders and their registering organisations will be required to...

Author(s)
Wilson, B. J.; Wade, C. M.
Publisher
Springer, New York, USA
Citation
Mammalian Genome, 2012, 23, 1/2, pp 195-202
Abstract

The Drentsche patrijshond (Drent) is a relatively rare breed that is used as a versatile hunting dog. Although inherited diseases occur in this breed, no genetic mutations were previously known to contribute to these inherited disorders. Thirteen Drents were screened for 142 known ...

Author(s)
Shaffer, L. G.; Ramirez, C. J.; Sundin, K.; Carl, C.; Ballif, B. C.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record Case Reports, 2015, 3, 1, pp e000185
Abstract

Muscular dystrophies in dogs and cats represent a heterogeneous group of inherited, sometimes congenital, but infrequently diagnosed, progressive neuromuscular disorders. A correct identification and characterization of canine and feline muscular dystrophies could increase diagnostic and treatment...

Author(s)
Salvadori, C.; Vattemi, G.; Guglielmi, V.; Marini, M.; Tomelleri, G.; Cantile, C.
Publisher
Elsevier Inc, Orlando, USA
Citation
Topics in Companion Animal Medicine, 2021, 42,

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