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VetMed Resource

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Abstract

Intestinal Mφ play a pivotal role in the maintenance of gut homeostasis, but can also contribute to inflammation such as inflammatory bowel disease (IBD). In contrast to human tissues, little is known about phenotypes of Mφ in the canine gastrointestinal tract. Therefore, an immunohistochemical...

Author(s)
Wagner, A.; Junginger, J.; Lemensieck, F.; Hewicker-Trautwein, M.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2018, 197, pp 49-57
Abstract

The pathogenesis of canine inflammatory bowel disease (IBD) involves complex interactions between mucosal immunity and the intestinal microbiota. Glucocorticoids are commonly administered to reduce mucosal inflammation and gastrointestinal signs. The study objective was to evaluate the effects of...

Author(s)
Atherly, T.; Rossi, G.; White, R.; Seo YeonJung; Wang Chong; Ackermann, M.; Breuer, M.; Allenspach, K.; Mochel, J. P.; Jergens, A. E.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 12, pp e0226780
Abstract

Inflammatory bowel disease (IBD) is a common gastrointestinal disease in dogs. Decreased production of intestinal immunoglobulin A (IgA) has been suggested as a possible pathogenesis in a subset of canine IBD; however, the underlying cause remains unclear. Sphingosine-1-phosphate (S1P) is a lipid...

Author(s)
Nakazawa, M.; Maeda, S.; Yokoyama, N.; Nakagawa, T.; Yonezawa, T.; Ohno, K.; Matsuki, N.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 9, pp 1249-1258
Abstract

Although antimicrobial peptides (AMPs) play an integral role in the regulation of intestinal microbiota and homeostasis, their expression in canine gastrointestinal diseases, including idiopathic inflammatory bowel disease (IBD) and intestinal lymphoma, remains unknown. The objective of this study...

Author(s)
Nakazawa, M.; Maeda, S.; Omori, M.; Kaji, K.; Yokoyama, N.; Nakagawa, T.; Chambers, J. K.; Uchida, K.; Ohno, K.; Yonezawa, T.; Matsuki, N.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2019, 249, pp 47-52
Abstract

Idiopathic inflammatory bowel disease (IBD) in dogs can be challenging to diagnose and fecal markers of disease that correlate with its severity could potentially be clinically useful. Surrogate inflammatory markers, such as the concentration of fecal S100A12, are used to detect active IBD in...

Author(s)
Heilmann, R. M.; Grellet, A.; Allenspach, K.; Lecoindre, P.; Day, M. J.; Priestnall, S. L.; Toresson, L.; Procoli, F.; Grützner, N.; Suchodolski, J. S.; Steiner, J. M.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2014, 158, 3/4, pp 156-166
Abstract

Prior studies have failed to detect a convincing association between histologic lesions of inflammation and clinical activity in dogs with inflammatory bowel disease (IBD). We hypothesized that use of a simplified histopathologic scoring system would improve the consistency of interpretation among...

Author(s)
Allenspach, K. A.; Mochel, J. P.; Du YingZhou; Priestnall, S. L.; Moore, F.; Slayter, M.; Rodrigues, A.; Ackermann, M.; Krockenberger, M.; Mansell, J.; Luckschander, N.; Wang Chong; Suchodolski, J.; Berghoff, N.; Jergens, A. E.
Publisher
Sage Publications, Thousand Oaks, USA
Citation
Veterinary Pathology, 2019, 56, 3, pp 435-443
Abstract

Background: Inflammatory bowel disease (IBD) refers to a diverse group of chronic gastrointestinal diseases, and gut microbial dysbiosis has been proposed as a modulating factor in its pathogenesis. Several studies have investigated the gut microbial ecology of dogs with IBD but it is yet unclear...

Author(s)
Xu Jia; Verbrugghe, A.; Lourenço, M.; Janssens, G. P. J.; Liu, D. J. X.; Wiele, T. van de; Eeckhaut, V.; Immerseel, F. van; Maele, I. van de; Niu YuFeng; Bosch, G.; Junius, G.; Wuyts, B.; Hesta, M.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2016, 12, 114, pp (16 June 2016)
Abstract

Background: Little information is available of markers that assess the disease course in dogs with idiopathic inflammatory bowel disease (IBD). Objectives: Evaluate relationship between disease severity and serum and fecal biomarkers in dogs with idiopathic IBD before and after treatment. Animals:...

Author(s)
Otoni, C. C.; Heilmann, R. M.; García-Sancho, M.; Sainz, A.; Ackermann, M. R.; Suchodolski, J. S.; Steiner, J. M.; Jergens, A. E.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2018, 32, 3, pp 999-1008
Abstract

The exact pathogenesis of idiopathic inflammatory bowel disease (IBD) in humans as well as dogs remains largely unknown, although it is believed to represent a multifactorial immune-mediated disease, resulting from complex interplay between the mucosal immune system and the intestinal microbiome in ...

Author(s)
Hawes, M.; Riddle, A.; Kirk, J.; Jergens, A.; Allenspach, K.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2018, 183, 17, pp 536
Abstract

Although alteration of commensal microbiota is associated with chronic gastrointestinal (GI) diseases such as inflammatory bowel disease (IBD) in dogs, the microbiota composition in intestinal lymphoma, an important differential diagnosis of canine IBD, has not been investigated. The objective of...

Author(s)
Omori, M.; Maeda, S.; Igarashi, H.; Ohno, K.; Sakai, K.; Yonezawa, T.; Horigome, A.; Odamaki, T.; Matsuki, N.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2017, 79, 11, pp 1840-1847

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