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Abstract

Intestinal Mφ play a pivotal role in the maintenance of gut homeostasis, but can also contribute to inflammation such as inflammatory bowel disease (IBD). In contrast to human tissues, little is known about phenotypes of Mφ in the canine gastrointestinal tract. Therefore, an immunohistochemical...

Author(s)
Wagner, A.; Junginger, J.; Lemensieck, F.; Hewicker-Trautwein, M.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2018, 197, pp 49-57
Abstract

Background: Canine inflammatory bowel disease (IBD) is a group of chronic gastrointestinal (GI) disorders of still largely unknown etiology. Canine IBD diagnosis is time-consuming and costly as other diseases with similar signs should be initially excluded. In human IBD microRNA (miR) expression...

Author(s)
Konstantinidis, A. O.; Pardali, D.; Adamama-Moraitou, K. K.; Gazouli, M.; Dovas, C. I.; Legaki, E.; Brellou, G. D.; Savvas, I.; Jergens, A. E.; Rallis, T. S.; Allenspach, K.
Publisher
BioMed Central Ltd, London, UK
Citation
BMC Veterinary Research, 2020, 16, 69, pp (22 February 2020)
Abstract

Inflammatory bowel disease (IBD) is a multifactorial chronic inflammatory disorder leading to structural changes in the intestinal wall. In humans, the neutrophil-to-lymphocyte ratio (NLR) has been proposed as a promising marker of IBD. This study evaluated the possible clinical and prognostic...

Author(s)
Benvenuti, E.; Pierini, A.; Gori, E.; Lucarelli, C.; Lubas, G.; Marchetti, V.
Publisher
MDPI AG, Basel, Switzerland
Citation
Veterinary Sciences, 2020, 7, 3,
Abstract

Background: The use of serological markers to diagnose inflammatory bowel disease (IBD) in humans is well-established. Because of the frequency of IBD in dogs and resources required for its diagnosis with current methods, new approaches are desired. Objective: The goal is to evaluate novel...

Author(s)
Estruch, J. J.; Barken, D.; Bennett, N.; Krawiec, D. K.; Ogilvie, G. K.; Powers, B. E.; Polansky, B. J.; Sueda, M. T.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Internal Medicine, 2020, 34, 3, pp 1177-1186
Abstract

Canine inflammatory bowel disease (IBD) is a chronic, immunologically mediated intestinal disorder, resulting from the complex interaction of genetic, environmental and immune factors. Hydrolyzed diets are used in dogs with food-responsive diarrhea (FRD) to reduce adverse responses to...

Author(s)
Ambrosini, Y. M.; Neuber, S.; Borcherding, D.; Seo YeonJung; Segarra, S.; Glanemann, B.; Garden, O. A.; Müller, U.; Adam, M. G.; Dang, V.; Borts, D.; Atherly, T.; Willette, A. A.; Jergens, A.; Mochel, J. P.; Allenspach, K.
Publisher
Frontiers Media S.A., Lausanne, Switzerland
Citation
Frontiers in Veterinary Science, 2020, 6, July,
Abstract

The pathogenesis of canine inflammatory bowel disease (IBD) involves complex interactions between mucosal immunity and the intestinal microbiota. Glucocorticoids are commonly administered to reduce mucosal inflammation and gastrointestinal signs. The study objective was to evaluate the effects of...

Author(s)
Atherly, T.; Rossi, G.; White, R.; Seo YeonJung; Wang Chong; Ackermann, M.; Breuer, M.; Allenspach, K.; Mochel, J. P.; Jergens, A. E.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2019, 14, 12, pp e0226780
Abstract

Inflammatory bowel disease (IBD) is a common gastrointestinal disease in dogs. Decreased production of intestinal immunoglobulin A (IgA) has been suggested as a possible pathogenesis in a subset of canine IBD; however, the underlying cause remains unclear. Sphingosine-1-phosphate (S1P) is a lipid...

Author(s)
Nakazawa, M.; Maeda, S.; Yokoyama, N.; Nakagawa, T.; Yonezawa, T.; Ohno, K.; Matsuki, N.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2019, 81, 9, pp 1249-1258
Abstract

Due to its difficult diagnosis and complicated treatment, inflammatory bowel disease (IBD) in dogs is a challenge for the veterinarian. Several aspects connected with pathological changes during IBD still remain unknown. Since one of these aspects is the participation of intestinal innervation in...

Author(s)
Rychlik, A.; Gonkowski, S.; Makowska, K.; Kaczmar, E.; Calka, J.
Publisher
Akadémiai Kiadó, Budapest, Hungary
Citation
Acta Veterinaria Hungarica, 2020, 68, 2, pp 154-159
Abstract

Although antimicrobial peptides (AMPs) play an integral role in the regulation of intestinal microbiota and homeostasis, their expression in canine gastrointestinal diseases, including idiopathic inflammatory bowel disease (IBD) and intestinal lymphoma, remains unknown. The objective of this study...

Author(s)
Nakazawa, M.; Maeda, S.; Omori, M.; Kaji, K.; Yokoyama, N.; Nakagawa, T.; Chambers, J. K.; Uchida, K.; Ohno, K.; Yonezawa, T.; Matsuki, N.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2019, 249, pp 47-52
Abstract

Idiopathic inflammatory bowel disease (IBD) in dogs can be challenging to diagnose and fecal markers of disease that correlate with its severity could potentially be clinically useful. Surrogate inflammatory markers, such as the concentration of fecal S100A12, are used to detect active IBD in...

Author(s)
Heilmann, R. M.; Grellet, A.; Allenspach, K.; Lecoindre, P.; Day, M. J.; Priestnall, S. L.; Toresson, L.; Procoli, F.; Grützner, N.; Suchodolski, J. S.; Steiner, J. M.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2014, 158, 3/4, pp 156-166

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