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Abstract

Canine hypoadrenocorticism likely arises from immune-mediated destruction of adrenocortical tissue, leading to glucocorticoid and mineralocorticoid deficiency. In humans with autoimmune Addison's disease (AAD) or autoimmune polyendocrine syndrome (APS), circulating autoantibodies have been...

Author(s)
Boag, A. M.; Christie, M. R.; McLaughlin, K. A.; Syme, H. M.; Graham, P.; Catchpole, B.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2015, 10, 11, pp e0143458
Abstract

Canine hypoadrenocorticism (Addison's disease), the 'great pretender' of internal medicine, is a disease that should be frequently considered as a differential diagnosis of several clinical presentations, albeit it is less commonly the actual cause of the clinical signs. Hypoadrenocorticism cannot...

Author(s)
Spence, S.; Gunn, E.; Ramsey, I.
Publisher
BMJ Publishing Group, London, UK
Citation
In Practice, 2018, 40, 7, pp 281-282, 285-290
Abstract

OBJECTIVE: To assess the discriminatory value for corticosteroid-induced alkaline phosphatase (CiALP) activity and other variables that can be measured routinely on a CBC and biochemical analysis for the diagnosis of hypoadrenocorticism in dogs. SAMPLE: Medical records of 57 dogs with confirmed ...

Author(s)
Borin-Crivellenti, S.; Garabed, R. B.; Moreno-Torres, K. I.; Wellman, M. L.; Gilor, C.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2017, 78, 10, pp 1171-1181
Abstract

Objectives: To determine if a urine sodium concentration could be used to rule out hypoadrenocorticism in hyponatraemic dogs. Materials and methods: Medical records were reviewed for hyponatraemic dogs (serum sodium <135 mmol/L) that had recorded urine sodium concentrations. Twenty hyponatraemic dogs were included: 11 diagnosed with classical hypoadrenocorticism and nine with...

Author(s)
Lennon, E. M.; Hummel, J. B.; Vaden, S. L.
Publisher
Wiley, Oxford, UK
Citation
Journal of Small Animal Practice, 2018, 59, 4, pp 228-231
Abstract

Naturally occurring hypoadrenocorticism (Addison's disease) is uncommon, with an estimated prevalence in the canine population between 0.06% and 0.28%. This retrospective study evaluated the prevalence and clinical features of hypoadrenocorticism in Great Pyrenees (GP) dogs presented to the Centre...

Author(s)
Decôme, M.; Blais, M. C.
Publisher
Canadian Veterinary Medical Association, Ottawa, Canada
Citation
Canadian Veterinary Journal, 2017, 58, 10, pp 1093-1099
Abstract

The aim of this study was to describe the incidence and permanence of hypoadrenocorticism associated with trilostane treatment and to assess potential risk factors for hypoadrenocorticism. A retrospective cohort study was conducted using case records for 156 dogs treated with trilostane after a...

Author(s)
King, J. B.; Morton, J. M.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2017, 230, pp 24-29
Abstract

Hypoadrenocorticism is an uncommon disease in dogs and rare in humans, where it is known as Addison disease (ADD). The disease is characterized by a deficiency in corticosteroid production from the adrenal cortex, requiring lifelong hormone replacement therapy. When compared with humans, the...

Author(s)
Boag, A. M.; Catchpole, B.
Publisher
Elsevier Inc, Orlando, USA
Citation
Topics in Companion Animal Medicine, 2014, 29, 4, pp 96-101
Abstract

Autoantibodies directed against the P450 side chain cleavage enzyme (P450scc) have been recently described in dogs affected with hypoadrenocorticism, consistent with an immune-mediated pathogenesis of this endocrinopathy. In human autoimmune Addison's disease, autoantibodies may have a predictive...

Author(s)
Boag, A. M.; Christie, M. R.; McLaughlin, K. A.; Syme, H. M.; Graham, P.; Catchpole, B.
Publisher
Elsevier B.V., Amsterdam, Netherlands
Citation
Veterinary Immunology and Immunopathology, 2018, 202, pp 41-45
Abstract

Primary hypoadrenocorticism, also known as Addison's disease and nicknamed 'the great pretender', is a rare disease in dogs and has been sporadically documented in cats. Documented cases of confirmed hypoadrenocorticism as a cause of neurological signs are limited. This report describes two cases...

Author(s)
Santifort, K. M.; Kooistra, H. S.; Mandigers, P. J. J.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record Case Reports, 2018, 6, 4, pp e000669
Abstract

Objectives: To describe the clinicopathologic findings and outcome in dogs with atypical hypoadrenocorticism (Group 1) and dogs with suspected atypical hypoadrenocorticism whose post-adrenocorticotropic hormone stimulation cortisol concentrations were greater than 55 nmol/L but below the laboratory ...

Author(s)
Wakayama, J. A.; Furrow, E.; Merkel, L. K.; Armstrong, P. J.
Publisher
Wiley, Oxford, UK
Citation
Journal of Small Animal Practice, 2017, 58, 7, pp 365-371

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