Latent canine herpesvirus-1 (CHV-1) infections are common in domestic dogs, but stimuli causing viral reactivation and recrudescent disease are poorly understood. Immunosuppressive pharmaceuticals are currently the only experimentally established triggers for recurrent ocular CHV-1 infection in ...
Author(s)
Nicklin, A. M.; McEntee, M. C.; Ledbetter, E. C.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Microbiology, 2014, 174, 3/4, pp 433-437
OBJECTIVE: To determine the effects of topical ocular application of 1% trifluridine ophthalmic solution in dogs with experimentally induced recurrent ocular canine herpesvirus-1 (CHV-1) infection. ANIMALS: 10 specific pathogen-free Beagles. PROCEDURES: 12 months prior to the beginning of the...
Author(s)
Spertus, C. B.; Mohammed, H. O.; Ledbetter, E. C.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2016, 77, 10, pp 1140-1147
The canine infectious respiratory disease complex (CIRDC) is an endemic worldwide syndrome involving multiple viral and bacterial pathogens. Traditionally, Bordetella bronchiseptica (Bb), canine adenovirus type 2 (CAV-2), canine distemper virus (CDV), canine herpesvirus (CHV) and canine...
Author(s)
Day, M. J.; Carey, S.; Clercx, C.; Kohn, B.; Marsilio, F.; Thiry, E.; Freyburger, L.; Schulz, B.; Walker, D. J.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Journal of Comparative Pathology, 2020, 176, pp 86-108
OBJECTIVE: To determine the in vitro half maximal effective concentration (EC50) of ganciclovir for canine herpesvirus-1 (CHV-1) and to evaluate the efficacy of ganciclovir ophthalmic gel in dogs with experimentally induced ocular CHV-1 infection. ANIMALS: 10 specific pathogen-free adult Beagles....
Author(s)
Ledbetter, E. C.; Nicklin, A. M.; Spertus, C. B.; Pennington, M. R.; Walle, G. R. van de; Mohammed, H. O.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2018, 79, 7, pp 762-769
Latent canine herpesvirus-1 (CHV-1) infections are common in domestic dogs and reactivation of latent virus may be associated with recurrent ocular disease. The objectives of the present study were to evaluate the ability of a subunit CHV-1 vaccine to stimulate peripheral CHV-1 specific immunity...
Author(s)
Ledbetter, E. C.; Kim Kay; Dubovi, E. J.; Mohammed, H. O.; Felippe, M. J. B.
Publisher
Elsevier B. V., Amsterdam, Netherlands
Citation
Veterinary Microbiology, 2016, 197, pp 102-110
Latent canine herpesvirus-1 (CHV-1) infection is common in domestic dogs, but triggers for viral reactivation and recrudescent CHV-1 disease are poorly understood. Cyclophosphamide is a potent immunosuppressive and myelosuppressive agent used for the therapy of a variety of neoplastic and...
Author(s)
Mundy, P.; Silva, E. C. da; Ledbetter, E. C.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Microbiology, 2012, 159, 1/2, pp 230-235
Wild raccoon dogs (Nyctereutes procyonoides koreensis) may play a role transmitting several pathogens to humans and pet animals. Information concerning the incidence of rabies, canine distemper virus (CDV), canine parvovirus (CPV), canine adenovirus type 2 (CAdV-2), canine parainfluenza virus type...
Author(s)
Yang DongKun; Lee SeougHeon; Kim HaHyun; Kim JongTaek; Ahn SangIn; Cho InSoo
Publisher
Korean Society of Veterinary Science, Daejon, Korea Republic
Citation
Korean Journal of Veterinary Research, 2017, 57, 4, pp 209-214
The Canine herpesvirus-1 (CHV-1) is causing in dogs a wide range of reproductive problems: infertility, foetal resorption, abortion, weak puppies, stillborn, low conception rate, small litter size and neonatal mortality, according to the age and pregnancy stage. The aims of the study where to...
Author(s)
Cobzariu, D.; Necula, G. A.; Bărăităreanu, S.; Ștefan, G.; Daneș, D.
Publisher
University of Agronomic Sciences and Veterinary Medicine of Bucharest, Bucharest, Romania
Citation
Scientific Works. Series C. Veterinary Medicine, 2018, 64, 2, pp 23-28
Objective-To determine the frequency of spontaneous canine herpesvirus-1 (CHV-1) reactivation and ocular viral shedding in latently infected dogs and the effect of topical ocular administration of cyclosporine. Animals-8 mature Beagles with experimentally induced latent CHV-1 infection....
Author(s)
Ledbetter, E. C.; Silva, E. C. da; Kim, S. G.; Dubovi, E. J.; Schwark, W. S.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2012, 73, 7, pp 1079-1084
Causes of abortion in bitches or perinatal puppy loss in dogs mostly are unknown. One of possible causes is canine herpesvirus-1 (CHV-1) infections. It is presumed that virus is enzootic in dogs all over the world and studies in several Europian countries indicates a high seroprevalence. In this...
Author(s)
Gracin, K.; Lojkić, M.; Stevanović, V.
Publisher
Hrvatska Veterinarska Komora, Veterinarski Fakultet in Zagrebu, Zagreb, Croatia
Citation
6. Hrvatski Veterinarski Kongres s međunarodnim sudjelovanjem, od 26. do 29. listopada 2016, Opatija, Hrvatska. Zbornik Radova, 2016, pp 489-494