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Abstract

Background: Melatonin is a hormone produced and secreted primarily by the pineal gland and mainly metabolised in the liver. Increased melatonin concentrations have been reported in human cirrhosis and hepatic encephalopathy (HE), a syndrome of neurological dysfunction. The pathogenesis of canine HE ...

Author(s)
Ferreira, M. da F.; Mellanby, R. J.; Gow, A. G.
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2020, 187, 3, pp e23-e23
Abstract

Objective - To elucidate the relationship between plasma ammonia concentration and severity of hepatic encephalopathy and determine whether factors that precipitate hepatic encephalopathy in humans are associated with the presence of clinical signs of hepatic encephalopathy in dogs previously...

Author(s)
Lidbury, J. A.; Ivanek, R.; Suchodolski, J. S.; Steiner, J. M.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2015, 247, 2, pp 176-183
Abstract

Hyperammonaemia is a common complication of liver disease in dogs. High concentrations of ammonia can be detrimental to dogs with liver disease for several reasons, notably by causing hepatic encephalopathy (HE) which describes the wide range of neurological abnormalities ranging from altered...

Author(s)
Breheny, C. R.; Mellanby, R. J.; Hamilton, J. A.; Gow, A. G.
Publisher
Springer, Dordrecht, Netherlands
Citation
Veterinary Research Communications, 2018, 42, 3, pp 221-225
Abstract

Objectives: Increased whole blood manganese concentrations have been reported in humans with primary liver disease. Due to the neurotoxic effects of manganese, altered manganese homeostasis has been linked to the development of hepatic encephalopathy. Whole blood manganese concentrations are...

Author(s)
Kilpatrick, S.; Jacinto, A.; Foale, R. D.; Tappin, S. W.; Burton, C.; Frowde, P. E.; Elwood, C. M.; Powell, R.; Duncan, A.; Mellanby, R. J.; Gow, A. G.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Small Animal Practice, 2014, 55, 5, pp 241-246
Abstract

Gallbladder agenesis is a congenital malformation that is considered extremely rare in dogs. The disease can course asymptomatically or with clinical signs, usually non-specific and including vomiting, anorexia, diarrhea, ascites, and lethargy. The objective of this report was to describe the...

Author(s)
Oliveira, F. B.; Fontes, T. N.; Sousa, M. C.; Néto Souza, A. C. da S.; Peixoto, T. da C.; Leal, P. V.
Publisher
Universidade Federal Rural do Semi-Árido (UFERSA), Mossoro, Brazil
Citation
Acta Veterinaria Brasilica, 2021, 15, 2, pp 96-101
AbstractFull Text

Background: Congenital portosystemic shunt (cPSS) is one of the most common congenital disorders diagnosed in dogs. Hepatic encephalopathy (HE) is a frequent complication in dogs with a cPSS and is a major cause of morbidity and mortality. Despite HE been a major cause of morbidity in dogs with a...

Author(s)
Williams, A.; Gow, A.; Kilpatrick, S.; Tivers, M.; Lipscomb, V.; Smith, K.; Day, M. O.; Jeffery, N.; Mellanby, R. J.
Publisher
Korean Society of Veterinary Science, Seoul, Korea Republic
Citation
Journal of Veterinary Science, 2020, 21, 3,
Abstract

Objective: To comparatively review the pathogenesis, clinical presentation, diagnosis, and management of hepatic encephalopathy (HE) in dogs and cats. Data Sources: The Medline database was searched for articles related to HE in people, dogs, and cats. Articles published within the last 5 years...

Author(s)
Lidbury, J. A.; Cook, A. K.; Steiner, J. M.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Veterinary Emergency and Critical Care, 2016, 26, 4, pp 471-487
Abstract

Objective - To investigate clinical use of proton magnetic resonance spectroscopy (1H MRS) and to compare metabolic brain bioprofiles of dogs with and without hepatic encephalopathy. Animals - 6 dogs with hepatic encephalopathy and 12 control dogs. Procedures - Conventional MRI and single-voxel 1H...

Author(s)
Carrera, I.; Kircher, P. R.; Meier, D.; Richter, H.; Beckman, K.; Dennler, M.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
American Journal of Veterinary Research, 2014, 75, 9, pp 818-827
Abstract

Objective: To characterize the clinical presentation and outcome of dogs with acute liver failure (ALF). Design: Retrospective case series from January 1995 to December 2012. Setting: University teaching hospital. Animals: Forty-nine dogs were diagnosed with ALF defined as the acute onset of...

Author(s)
Lester, C.; Cooper, J.; Peters, R. M.; Webster, C. R. L.
Publisher
Wiley-Blackwell, Oxford, UK
Citation
Journal of Veterinary Emergency and Critical Care, 2016, 26, 4, pp 559-567
Abstract

Objective: To describe the use of manual therapeutic plasma exchange (TPE) to manage hepatic encephalopathy (HE) in a dog. Case summary: A 9-year-old neutered female Dachshund presented for HE secondary to a previously diagnosed portosystemic shunt. The hyperammonemia and severe clinical signs of...

Author(s)
Culler, C. A.; Reinhardt, A.; Vigani, A.
Publisher
Wiley, Boston, USA
Citation
Journal of Veterinary Emergency and Critical Care, 2020, 30, 3, pp 312-317

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