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Abstract

Introduction: Canine models of severe haemophilia resemble their human equivalents both regarding clinical bleeding phenotype and response to treatment. Therefore pre-clinical studies in haemophilia dogs have allowed researchers to make valuable translational predictions regarding the potency and...

Author(s)
Madsen, D. E.; Nichols, T. C.; Merricks, E. P.; Waters, E. K.; Wiinberg, B.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2017, 12, 4, pp e0175030
Abstract

A male Great Dane was referred to the Small Animal Clinic, University of Veterinary Medicine Hannover at seven months of age with a known bleeding history. The dog was diagnosed with haemophilia A (factor VIII activity: 4%). To identify the underlying genetic defect responsible for haemophilia in...

Author(s)
Rodríguez, P. A.; Kehl, A.; Cecil, A.; Shityakov, S.; Dandekar, T.; Mueller, E.; Mischke, R.
Publisher
Schlütersche Verlagsgesellschaft GmbH & Co. KG, Hannover, Germany
Citation
Berliner und Münchener Tierärztliche Wochenschrift, 2018, 131, 1/2, pp 65-68
Abstract

Severe hemophilia A (HA) is an inherited bleeding disorder characterized by <1% of residual factor VIII (FVIII) clotting activity. The disease affects several mammals including dogs, and, like humans, is associated with high morbidity and mortality. In gene therapy using adeno-associated viral (AAV) vectors, the canine model has been one of the best predictors of the therapeutic dose tested in...

Author(s)
Callan, M. B.; Haskins, M. E.; Wang Ping; Zhou ShangZhen; High, K. A.; Arruda, V. R.
Publisher
Public Library of Sciences (PLoS), San Francisco, USA
Citation
PLoS ONE, 2016, 11, 3, pp e0151800
Abstract

Haemophilia B in Rhodesian Ridgebacks is currently the most important canine haemophilia in Germany. The aim of this study was to define the underlying genetic defect. Genetic studies were performed including six phenotypically affected male dogs (factor IX activity: approximately 1%), four...

Author(s)
Mischke, R.; Kühnlein, P.; Kehl, A.; Langbein-Detsch, I.; Steudle, F.; Schmid, A.; Dandekar, T.; Czwalinna, A.; Müller, E.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2011, 187, 1, pp 113-118
Abstract

Background: Hemophilia A is an X-linked disorder caused by a deficiency in coagulation factor VIII. Over 2300 unique mutations in the gene-encoding factor VIII have been documented in people, but limited information is known in dogs. An 11-week-old male Boxer and a 5-year-old male German Shepherd...

Author(s)
Christopherson, P. W.; Bacek, L. M.; King, K. B.; Boudreaux, M. K.
Publisher
Wiley-Blackwell, Boston, USA
Citation
Veterinary Clinical Pathology, 2014, 43, 3, pp 312-316
Abstract

Objective - To evaluate the clinical course of dogs with hemophilia A (factor VIII deficiency) and to determine whether factor VIII coagulant activity (FVIII:C) was associated with severity of clinical signs and outcome. Design - Survey study. Sample - Respondent information for 39 client-owned ...

Author(s)
Aslanian, M. E.; Sharp, C. R.; Rozanski, E. A.; Laforcade, A. M. de; Rishniw, M.; Brooks, M. B.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2014, 245, 6, pp 677-683
Abstract

The aim of this study was to report a case of canine classical hemophilia. A Dachshund dog, male, one year old, was admitted at a veterinary teaching hospital due to intense epistaxis from more than one day. The patient showed pale mucous membranes, neck hematomas, apathy and inappetence. Due to...

Author(s)
Dalmolin, M. L.; Lacerda, L. de A.; Stedile, S. T. de O.; Pedralli, V.; Tourrucôo, A. C.
Publisher
Faculdade de Veterinaria, Universidade Federal Fluminense, Niterói, Brazil
Citation
Revista Brasileira de Ciência Veterinária, 2013, 20, 3, pp 127-131
Abstract

Objectives: This case report describes for the first time a bone haemophilic pseudotumour in a dog. Case description: A seven-month-old German Shepherd male dog was presented with the complaint of a forelimb weight-bearing lameness with major swelling that expanded dramatically after fine needle...

Author(s)
Decambron, A.; Manassero, M.; Thibaud, J.; Reyes-Gomez, E.; Viateau, V.
Publisher
Schattauer GmbH, Stuttgart, Germany
Citation
Veterinary and Comparative Orthopaedics and Traumatology, 2017, 30, 5, pp 371-376
Abstract

A point mutation in the coagulation factor VIII (FVIII) gene in a dog suffering from severe FVIII deficiency was described. Genetic analyses were performed on a male German shepherd dog with known severe haemophilia A. The family history of the dog indicated further affected dogs. However, at the...

Author(s)
Mischke, R.; Wilhelm, C.; Czwalinna, A.; Varvenne, M.; Narten, K.; Depka, M. von
Publisher
BMJ Publishing Group, London, UK
Citation
Veterinary Record, 2011, 169, 19, pp 496
Abstract

Continuous expression of activated factor VII (FVIIa) via gene transfer is a potential therapeutic approach for hemophilia patients with or without inhibitory antibodies to human factor VIII (FVIII) or IX (FIX). Here, we investigate whether gene transfer of an engineered canine FVIIa (cFVIIa)...

Author(s)
Margaritis, P.; Roy, E.; Aljamali, M. N.; Downey, H. D.; Giger, U.; Zhou, S. Z.; Merricks, E.; Dillow, A.; Ezban, M.; Nichols, T. C.; High, K. A.
Publisher
American Society of Hematology, Washington, USA
Citation
Blood, 2009, 113, 16, pp 3682-3689

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