Neutrophils from a male Irish Setter dog with a clinical history of recurrent life-threatening bacterial infections were studied. Increased susceptibility to infection in the affected dog was associated with a defect in the capacity to kill phagocytized bacteria. In comparison with normal cells the ...

The disease which is thought to be similar to leukocyte adhesion deficiency in cattle and man (probably caused by lack of 2 cell surface proteins on granulocytes CD11b and CD18) is described. Affected animals suffer repeated bouts of bacterial infections which respond to antibiotics but relapse...

The following primary immunodeficiencies are described: canine cyclic haematopoiesis (Collies), canine granulocytopathy syndrome (Irish Setters), neutrophil bacteriocidal defect (Dobermann Pinschers), Pelger-Huët anomaly (Domestic Shorthair cat and various canine breeds), Chédiak-Higashi syndrome...

A male Irish Setter dog had a clinical history of recurrent life-threatening bacterial infections, with associated periods of pyrexia and severe neutrophilia. Examination of a mandibular lymph node biopsy sample taken when the patient was 10 weeks old revealed subacute diffuse suppurative...

The authors describe 11 primary immunodeficiencies of the dog: immunodeficient dwarfism, lethal acrodermatitis, selective IgA and IgM deficiencies, transient hypogammaglobulinemia, severe combined X-linked immunodeficiency, complement C3 deficiency cyclic hematopoiesis, granulocytopathy, leukocyte...

A disease closely resembling the human neutrophil dysfunction syndromes was identified in a colony of dogs. The syndrome is characterized by recurrent life-threatening bacterial infections and a greatly shortened life span. The disease is genetically determined, being transmitted as an autosomal...