Gluten-sensitive enteropathy of the Irish Setter is an immune-mediated intolerance to gluten, the protein found in wheat, barley, rye, and oats, reminiscent of human celiac disease. Intestinal histological lesions include partial villous atrophy, infiltration of the lamina propria by lymphocytes...

The gluten-sensitive enteropathy (GSE) of Irish Setters is an immune-mediated food adverse reaction caused by gluten (the protein found in wheat, barley, rye and oat) which has several similarities with human celiac disease. Intestinal histological lesions include partial villous atrophy,...

This review discusses the genetic dissection of canine intestinal disease, explaining the concepts of segregation and linkage analysis by reference to a well-characterized gluten-sensitive enteropathy (GSE) of Irish setter (IS) dogs. It illustrates the continued value of basic genetic studies in...

This paper reports on case of gluten sensitive enteropathy in a 3-month-old male Labrador puppy admitted at the College of Veterinary and Animal Sciences Kerala Agricultural University, India. Emphasis of the report focused on the diagnosis and the dietary management given to the affected animal.

To investigate whether the MHC class II region is involved in canine gluten-sensitive enteropathy (GSE), a linkage study was performed in 2 large families of gluten-sensitive Irish Setter dogs. A total of 44 dogs in these pedigrees, along with 30 unrelated healthy Irish Setters, were genotyped for ...

44 dogs of a 6-generation family of Irish Setters with gluten-sensitive enteropathy (GSE) and 7 healthy Irish Setters were studied. The phenotype of each dog was determined after oral administration of gluten in the weaning diet, using morphometric evaluation of jejunal biopsies (all generations)...

A combined test of intestinal permeability using lactulose (L) and rhamnose (R), and absorptive function using xylose (X) and 3-O-methylglucose (G), was carried out at 4, 6, 8 and 16 weeks of age in 22 healthy control and 6 gluten-sensitive Irish setter (IS) dogs fed a diet containing a controlled...

Three Irish Setter dogs, presented at the Faculté de Médecine Vétérinaire at the Université de Montréal, had chronic diarrhoea and weight loss. One dog was 3 years old and was the mother of the other 2, which were males of 1 and 2 years. On endoscopic examination all dogs had very irregular...

Jejunal biopsies taken from three 8-month-old gluten-sensitive enteropathy (GSE)-affected dogs reared on a normal gluten-containing diet exhibited partial villous atrophy and contained more intra-epithelial lymphocytes than controls. The morphological abnormalities were reversed by feeding a...

Chronic enteropathies are a common and diverse group of diseases in the dog, but diagnosis can be difficult and morphological criteria are an inadequate means of classification. The enteropathies are listed as gluten-sensitive enteropathy, bacterial overgrowth, canine "sprue",...