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Abstract

Canine polyneuropathy is a neurological disorder characterized by a dysfunction of multiple peripheral nerves. The etiology of the disease is diverse; it may occur in cases of infectious, immune-mediated, or hereditary conditions or in association with endocrinopathy, neoplasm, or chemical...

Author(s)
Tsuboi, M.; Uchida, K.; Ide, T.; Ogawa, M.; Inagaki, T.; Tamura, S.; Saito, M.; Chambers, J. K.; Nakayama, H.
Publisher
Japanese Society of Veterinary Science, Tokyo, Japan
Citation
Journal of Veterinary Medical Science, 2013, 75, 3, pp 327-335
Abstract

The neuropathy produced by the hexacarbon 2,5-hexanedione (2,5-HD) resembles human and canine inherited giant axonal neuropathy (GAN) in the presence of giant axonal swellings that contain accumulations of neurofilaments. The accumulations are both paranodal and internodal in GAN and 2,5-HD induced ...

Author(s)
King, R. H. M.; Sarsilmaz, M.; Thomas, P. K.; Jacobs, J. M.; Muddle, J. R.; Duncan, I. D.
Citation
Neuropathology & Applied Neurobiology, 1993, 19, 3, pp 224-232
Abstract

A chronic progressive neurological condition in an Alexandrine parrot (Psittacula eupatria) was manifest as intention tremors, incoordination, and seizure activity. Histology revealed large eosinophilic bodies throughout the central nervous system, and electron microscopy demonstrated that these...

Author(s)
Stent, A.; Gosbell, M.; Tatarczuch, L.; Summers, B. A.
Publisher
American Association of Veterinary Laboratory Diagnosticians, Davis, USA
Citation
Journal of Veterinary Diagnostic Investigation, 2015, 27, 5, pp 611-615
Abstract

The most common clinical signs of hypothyroidism are those of a decreased metabolic rate and dermatological manifestations. There is strong evidence for a causal relation between hypothyroidism and a variety of neurological abnormalities The peripheral and central nervous systems may be affected by ...

Author(s)
Georgescu, G.; Codreanu, M. D.
Publisher
Universitatea de Științe Agricole și Medicină Veterinară"Ion Ionescu de la Brad" Iași, Iași, Romania
Citation
Lucrări Științifice - Medicină Veterinară, Universitatea de Științe Agricole și Medicină Veterinară "Ion Ionescu de la Brad" Iași, 2007, 51, 10(1), pp 337-340
Abstract

Giant axonal neuropathy is a newly discovered, neurological disease of the German Shepherd which is probably inherited as an autosomal recessive trait. The clinical features of the disease, its differential diagnosis and pathology are discussed in this review. First signs of weakness and ataxia...

Author(s)
Duncan, I. D.; Griffiths, I. R.
Citation
Journal of Small Animal Practice, 1981, 22, 8, pp 491-501
Abstract

The disease occurred in 2 of 8 pups from one litter and in 3 of 11 pups from another litter of a pair of Alsatians. Both sexes were affected. Autosomal recessive inheritance is suggested.

Author(s)
Griffiths, I. R.; Duncan, I. D.; Carmichael, S.; Henderson, S.
Publisher
Pitman Medical Limited., Tunbridge Wells, UK
Citation
Animal models of neurological disease., 1980, pp 103-109
Abstract

An 18-month-old Alsatian had hind leg ataxia, weakness, hypotonia and loss of patellar reflexes. Electrophysiological studies demonstrated denervation of the distal hind leg muscles and abnormal nerve conduction velocities. Biopsy and post mortem examination of the peripheral nervous system (PNS)...

Author(s)
Duncan, I. D.; Griffiths, I. R.
Citation
Veterinary Record, 1977, 101, 22, pp 438-441
Abstract

In a dog with giant axonal neuropathy, swollen axons containing excessive and disorganized neurofilaments were present in the spinal cord, mainly at the distal portions of long tracts.

Author(s)
Griffiths, I. R.; Duncan, I. D.
Citation
Acta Neuropathologica, 1979, 46, 3, pp 169-172
Abstract

Author(s)
Griffiths, I. R.; Duncan, I. D.; McCulloch, M.; Carmichael, S.
Citation
Neuropathology and Applied Neurobiology, 1980, 6, 3, pp 239
Abstract

Axonal swellings were found predominantly in the distal portions of the tibial and recurrent laryngeal nerves. Excess neurofilaments, often arranged in whorls, were present in the swellings which were found in both myelinated and non-myelinated fibres. Other axonal organelles tended to be isolated...

Author(s)
Duncan, I. D.; Griffiths, I. R.
Citation
Neuropathology and Applied Neurobiology, 1979, 5, 1, pp 25-39

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