Objective: To report the management and outcome of a dog with canine monocytic ehrlichiosis and nonregenerative pancytopenia, with high doses of filgrastim. Case Description: An 8-year-old male, mixed-breed dog, weighing 5.6 kg, presented with a 1-month history of hyporexia, adynamia, and a weight...

A 5.5 year-old male, Belgian Shepherd dog, weighing 28 kg, was presented with a history of nasal bleeding, high temperature and general weakness. On clinical examination general condition of the dog was poor with tachycardia, and marked pallor of the mucous membranes. Complete blood count revealed...

Objective: To describe the management and outcome of a dog following a 10-fold dosing error of vincristine. Case Summary: A 2-year-old neutered female Toy Fox Terrier presenting for immune-mediated thrombocytopenia was administered an accidental overdose of vincristine (0.2 mg/kg [2.71 mg/m²]). The ...

A 3 years old male Belgian Shepherd dog body weight 35 kg was presented with one-month history of high fever, anorexia. ticks infestation on body and nasal bleeding. Clinical examination revealed high temperature. anemia. pale mucus membrane, epistaxis, tachycardia and depression. Hematological...

Background: Despite multiple reports of chemotherapy overdoses (ODs) in human and veterinary medicine, anthracycline ODs have been described infrequently. Hypothesis/Objectives: Describe toxicities, treatments, and overall outcome after anthracycline OD in dogs. Animals: Twelve mitoxantrone (MTX)...

5-Fluorouracil is an antineoplastic drug with a narrow therapeutic window. Pets are commonly exposed to the cream used for pre-malignant and malignant skin lesions in humans. 5-Fluorouracil poisoning is characterised by severe gastrointestinal (vomiting; diarrhoea; and gastrointestinal ulceration...

Off-label use of a human granulocyte colony stimulating factor (hG-CSF) has been allowed to treat dogs and cats with neutropenia. However, repeated administration of hG-CSF induces undesirable anti-drug antibody (ADA) responses, implying the necessity of animal-derived G-CSF as a therapeutic...

Disturbances in granulocyte count can occur in dogs and cats as the result of congenital or acquired (secondary) diseases. Neutropenia and agranulocytosis observed in peripheral blood tests (haemogram) are most often the result of bone marrow defects. Generally considered pathomechanisms are...

Filgrastim is the international non-proprietary name for recombinant human granulocyte colony-stimulating factor. Injected s.c. at 5 µg/kg, it helped to overcome neutropenia in 8 dogs with parvoviral infection and 14 dogs with other disorders, but had little effect in 10 cats with infectious...