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Abstract

Objective - To identify characteristics of exercise-induced collapse in Labrador Retrievers and compare characteristics for dogs with various dynamin 1 gene (DNM1) mutation statuses. Design - Retrospective cross-sectional study. Animals - 109 Labrador Retrievers with a history of recurrent ...

Author(s)
Furrow, E.; Minor, K. M.; Taylor, S. M.; Mickelson, J. R.; Patterson, E. E.
Publisher
American Veterinary Medical Association, Schaumburg, USA
Citation
Journal of the American Veterinary Medical Association, 2013, 242, 6, pp 786-791
Abstract

Paroxysmal events are notoriously difficult to characterise, as they are rarely witnessed by anyone other than the owner and between episodes these dogs are completely normal. Add to this the fact that many of these transient events are caused by a chemical interference within the central nervous...

Author(s)
Lowrie, M.
Publisher
MA Healthcare Limited, London, UK
Citation
Companion Animal, 2017, 22, 12, pp 724-728
Abstract

The mutation resulting in exercise-induced collapse and the genetic test to diagnose the disease in Labrador Retrievers are described.

Author(s)
Erace, J.
Publisher
Veterinary Learning Systems Inc., Yardley, USA
Citation
Veterinary Technician, 2013, 34, 5, pp unpaginated
AbstractFull Text

The exercise-induced collapse (EIC) is a hereditary disease characterized by muscle weakness, impaired locomotion and collapse after intense exercise. This autossomic recessive disorder affects mainly Labrador Retriever presenting the mutation c.767 G > T in the dynamin 1 (DNM1) gene. The objective ...

Author(s)
Basso, R. M.; Oliveira Filho, J. P. de; Palumbo, M. I. P.; Zakia, L. S.; Araújo Júnior, J. P.; Borges, A. S.
Publisher
Centro de Ciências Rurais, Universidade Federal de Santa Maria, Santa Maria, Brazil
Citation
Ciência Rural, 2014, 44, 9, pp 1629-1631
Abstract

Clinical and metabolic variables were evaluated in 13 dogs with border collie collapse (BCC) before, during, and following completion of standardized strenuous exercise protocols. Six dogs participated in a ball-retrieving protocol, and seven dogs participated in a sheep-herding protocol. Findings...

Author(s)
Taylor, S.; Shmon, C.; Su, L.; Epp, T.; Minor, K.; Mickelson, J.; Patterson, E.; Shelton, G. D.
Publisher
American Animal Hospital Association, Denver, USA
Citation
Journal of the American Animal Hospital Association, 2016, 52, 5, pp 281-290
Abstract

Exercise-induced collapse (EIC) is an autosomal recessive disorder in Labrador retrievers. In this study, an allele-specific PCR was developed to detect the point mutation G767T in exon 6 of canine DNM1, previously shown to be responsible for canine EIC. Of 133 Labrador retrievers tested in Japan,...

Author(s)
Takanosu, M.; Mori, H.; Suzuki, H.; Suzuki, K.
Publisher
Elsevier Ltd, Oxford, UK
Citation
Veterinary Journal, 2012, 193, 1, pp 293-295
Abstract

Objective: This retrospective study describes the signalment, clinical presentation, diagnostic findings, and mode of inheritance in four young male English springer spaniel dogs with presumptive canine stress syndrome. Materials and methods: Appropriate cases were located through medical searches...

Author(s)
Thrift, E.; Wimpole, J. A.; Child, G.; Brown, N.; Gandolfi, B.; Malik, R.
Publisher
Dove Medical Press Ltd, Macclesfield, UK
Citation
Veterinary Medicine: Research and Reports, 2017, 8, pp 59-68
Abstract

Labrador retrievers are the most common dog breed in the world, with over 200 000 new kennel club registrations per year. The syndrome of exercise-induced collapse (EIC) in this breed is manifested by muscle weakness, incoordination and life-threatening collapse after intense exercise. Using a...

Author(s)
Patterson, E. E.; Minor, K. M.; Tchernatynskaia, A. V.; Taylor, S. M.; Shelton, G. D.; Ekenstedt, K. J.; Mickelson, J. R.
Publisher
Nature Publishing Group, New York, USA
Citation
Nature Genetics, 2008, 40, 10, pp 1235-1239
Abstract

A discussion on the clinical aspects and pathophysiology of EIC (exercise-induced collapse) in Labrador Retrievers, specifically those involved in competitions, hunting and gaming is presented. Focus is given on the genetic aspects of this disease.

Author(s)
Abitbol, M.
Publisher
Éditions du Point Vétérinaire, Maisons-Alfort, France
Citation
Point Vétérinaire, 2010, 41, 306, pp 16-17
Abstract

An episodic nervous system disorder triggered by strenuous exercise, termed border collie collapse (BCC), exists in border collies and related breeds. The genetic basis of BCC is unknown but is believed to be a complex genetic disorder. Our goal was to estimate the heritability (h2SNP) of BCC,...

Author(s)
Norton, E. M.; Minor, K. M.; Taylor, S. M.; McCue, M. E.; Mickelson, J. R.
Publisher
MDPI Publishing, Basel, Switzerland
Citation
Genes, 2021, 12, 12,

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